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New isatin derivatives

“…Recently the aminomethylation of isatin and 5-bromoisatin was performed with glycine, alanine, and sarcosine. It was shown that the reaction failed to proceed in ethanol but in acetic acid yields amounted to 45% [55] (Scheme 11).…”

“…Cyclic aminoacids reacting with isatin easily suffered decarboxylation giving spiro derivatives [55] (Scheme 12).…”

Action of Hydrazines on 2‐(2‐Oxindolin‐3‐ylidene)malononitrile, (E,Z)‐Ethyl 2‐cyano‐2‐(2‐oxindolin‐3‐ylidene)acetate and Isatin‐β‐thiosemicarbazone as a Source of Spiro Indoline‐pyrazole Systems

“…Substituted isatins are found in plants: melosatin alkaloids can be obtained from the caribbean tumorigenic plant Melochia tomentosa as well as in fungi; 6‐(3′‐methylbuten‐2′‐yl)isatin was isolated from Streptomyces albus . N‐substituted isatins are reported to show a wide range of biological activities such as antibacterial , anti‐fungal , antiviral , anti‐HIV and anti‐leukemia . These compounds were also reported to have effects on central nervous system .…”

Synthesis of new oxindole derivatives containing oxazolidin-2-one

“…1 For example, indole-2,3-diones, which represent a large family of heterocyclic compounds, have been extensively explored for developing pharmaceutically important molecules. N-Substituted isatins 2 especially are reported to show a wide range of biological activities such as antibacterial, 3 anti-fungal 4,5 antiviral 6 and anti-HIV, 7,8 antileukemia. 9 These compounds were also reported to have effects on central nervous system.…”