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Park, Yongsoon; Ito, Yoshihiro

doi:10.1023/a:1008154326954

Cited by 18 publications

(4 citation statements)

References 17 publications

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“…A variety of approaches have been taken to improve blood compatibility of polymeric materials [12]. Among them, a mostly valid one is the incorporation of heparin into biomaterials by dispersing heparin within the biomaterial, by ionic binding of heparin or by covalent immobilization [13][14][15][16]. Heparin is a naturally occurring sulfated linear polysaccharide and accelerates the antithrombin inhibition of the coagulation proteinases by several hundredfold, which forms the basis for clinical use as an anticoagulant.…”

Section: Introductionmentioning

confidence: 99%

Study on the preparation of collagen-modified silk fibroin films and their properties

Tang

Cao²,

Ma³

et al. 2006

Biomed. Mater.

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Blended films were prepared from a silk fibroin (SF) solution by adding a small amount of type I collagen (<5%). The mechanical properties of the wet films modified by collagen were improved obviously. The elongation at break reached 42%, and the smaller contact angles revealed that modified films had better hydrophilicity. 1% heparin was also added to modify the SF films to further improve the in vitro antithrombogenecity. The internal structure of the modified SF films was investigated with scanning electron microscopy, x-ray diffraction and Fourier transform infrared attenuated total reflection spectroscopy. The result indicates that the addition of a small amount of collagen and heparin did not change their conformation.

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Section: Introductionmentioning

confidence: 99%

Study on the preparation of collagen-modified silk fibroin films and their properties

Tang

Cao²,

Ma³

et al. 2006

Biomed. Mater.

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“…The findings revealed that the cells can adhere and spread well on lower RGD intermolecular spacing and disordered patterns. Finally, hyaluronic acid, galactose, heparin, insulin and EGF (epidermal growth factor) are good examples of biomolecules that were also micropatternimmobilised on substrates and displayed differential cell adhesion when compared to nonimmobilised substrates areas [305][306][307][308].…”

Section: A 2d Modelsmentioning

confidence: 99%

Molecular bionics – engineering biomaterials at the molecular level using biological principles

et al. 2019

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Life and biological units are the result of the supramolecular arrangement of many different types of molecules, all of them combined with exquisite precision to achieve specific functions. Taking inspiration from the design principles of nature allows engineering more efficient and compatible biomaterials. Indeed, bionic (from bion-, unit of life and -ic, like) materials have gained increasing attention in the last decades due to their ability to mimic some of the characteristics of nature systems, such as dynamism, selectivity, or signalling. However, there are still many challenges when it comes to their interaction with the human body, which hinder their further clinical development. Here we review some of the recent progress in the field of molecular bionics with the final aim of providing with design rules to ensure their stability in biological media as well as to engineer novel functionalities which enable navigating the human body.

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“…1) is expected to allow cells to continuously reconstitute damaged tissues stably and efficiently during the long period of their regeneration on inorganic materials. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Therefore, various growth factors, such as EGF, [16][17][18][19] fibroblast growth factor (FGF), [20][21][22][23][24] vascular endothelial growth factor (VEGF), [25][26][27][28][29][30][31] bone morphogenic proteins (BMPs), and others, [32][33][34][35][36][37][38][39][40][41][42] have been immobilized on inorganic materials (metal, glass, and ceramic) in the past 15 years. In this review, we focus on the immobilization of growth factors on inorganic materials for hard tissue engineering, especially for dental implants and bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

Inorganic material surfaces made bioactive by immobilizing growth factors for hard tissue engineering

Zhou

Ito

2013

RSC Adv.

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Medical and dental titanium has become the fundamental material in clinical use, in applications from surgical instruments and orthopedic rods to pins and plates. Besides titanium, various inorganic materials have been used in tissue engineering because of their unique mechanical properties. However, inorganic materials have no specific biological activities. The immobilization of growth factors on these materials is expected to add various biological functionalities that can regulate cell destinies, including not only adhesion but also cell growth or differentiation at the interface between these inorganic materials and biological tissues. This review discusses recent progress in the immobilization of growth factors on inorganic materials, including the methods and applications used for hard tissue engineering.

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Untitled

Cited by 18 publications

References 17 publications

Study on the preparation of collagen-modified silk fibroin films and their properties

Study on the preparation of collagen-modified silk fibroin films and their properties

Molecular bionics – engineering biomaterials at the molecular level using biological principles

Inorganic material surfaces made bioactive by immobilizing growth factors for hard tissue engineering

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