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Inhibition of NF-κB Signaling by Quinacrine Is Cytotoxic to Human Colon Carcinoma Cell Lines and Is Synergistic in Combination with Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) or Oxaliplatin

“…L-OHP is an analogue of cisplatin that has achieved modest success in the treatment of colorectal cancer. It has been found to have some activity as a single agent, but its antitumor effects are further enhanced when it is used in combination with other drugs that include FUra/LV, CPT-11, or taxanes (3)(4)(5)(6)(7)(8)(9). In addition to the increased efficacy, these combinations have resulted in decreased gastrointestinal toxicity as well as neurotoxicity, which are usually accompanied with L-OHP treatment (10).…”