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Bienzymatic Supramolecular Complex of Catalase Modified with Cyclodextrin‐Branched Carboxymethylcellulose and Superoxide Dismutase: Stability and Anti‐Inflammatory Properties

“…[7][8][9] In addition, the supramolecular association of cyclodextrinmodified enzymes with those chemically transformed with 1-adamantanyl residues has been reported. [10] On these bases, we could expect that glycosilation of CAT with a cyclodextrin-branched polymer and its further association with SOD previously modified with 1-adamantane (ADA) moieties might protect the later enzyme against inactivation toward H 2 O 2 .…”

New paramagnetic supramolecular adducts for MRI applications based on non-covalent interactions between Gd(III)-complexes and β- or γ-cyclodextrin units anchored to chitosan

“…Unfortunately, synthetic attempts to increase the size of the b-CD multimers were unsuccessful because they invariantly led to insoluble products. Soluble systems containing a larger number of CD units may however be obtained by functionalizing with CDs pre-existing polymers [20,21], yielding grafted polymers in which many CD molecules are supported on a polymeric carrier like carboxymethylcellulose (CMC) [22][23][24] or chitosan [25][26][27][28][29][30][31]. Chitosan is obtained by deacetylation of chitin, a natural polymer of b-(1-4)-Dglucosamine that is abundant in the hexoskeleton of crustaceans [32].…”

Improved pharmacological properties for superoxide dismutase modified with mannan

“…The functional properties of enzymes can be modulated by derivatization of their protein surface with macromolecular substances [1–4]. This strategy is especially successful when it is used to improve the pharmacological properties of enzymes with biomedical applications [5].…”