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Souza, N A; Souza, Fábio Santos de; Júnior, Irinaldo Diniz Basílio; Medeiros, Ana Cláudia Dantas de; Oliveira, Elder Eldervitch Carneiro de; Santos, Ana Flávia Oliveira; Macwdo, R. O.; Macêdo, Rui Oliveira

doi:10.1023/a:1024569414701

Cited by 30 publications

(8 citation statements)

References 11 publications

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“…The results show that a pure MET sample undergoes a one-stage thermal degradation process, whileCS-AlgNPs and MET-CS-AlgNPs samples are degraded in a three-stage process. For the MET sample, the decomposition process occurred between 137-288 • C and with a mineral residue of 0.9% [49], which was due to the vaporization of volatile components [50].…”

Section: Thermogravimetric Analysis Of Met-cs-algnps Nanocompositesmentioning

confidence: 99%

A Statistical Study on the Development of Metronidazole-Chitosan-Alginate Nanocomposite Formulation Using the Full Factorial Design

et al. 2020

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The goal of this study was to develop and statistically optimize the metronidazole (MET), chitosan (CS) and alginate (Alg) nanoparticles (NP) nanocomposites (MET-CS-AlgNPs) using a (21 × 31 × 21) × 3 = 36 full factorial design (FFD) to investigate the effect of chitosan and alginate polymer concentrations and calcium chloride (CaCl2) concentration ondrug loading efficiency(LE), particle size and zeta potential. The concentration of CS, Alg and CaCl2 were taken as independent variables, while drug loading, particle size and zeta potential were taken as dependent variables. The study showed that the loading efficiency and particle size depend on the CS, Alg and CaCl2 concentrations, whereas zeta potential depends only on the Alg and CaCl2 concentrations. The MET-CS-AlgNPs nanocomposites were characterized by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), scanning electron microscopy (SEM) and in vitro drug release studies. XRD datashowed that the crystalline properties of MET changed to an amorphous-like pattern when the nanocomposites were formed.The XRD pattern of MET-CS-AlgNPs showed reflections at 2θ = 14.2° and 22.1°, indicating that the formation of the nanocompositesprepared at the optimum conditions havea mean diameter of (165±20) nm, with a MET loading of (46.0 ± 2.1)% and a zeta potential of (−9.2 ± 0.5) mV.The FTIR data of MET-CS-AlgNPs showed some bands of MET, such as 3283, 1585 and 1413 cm−1, confirming the presence of the drug in the MET-CS-AlgNPs nanocomposites. The TGA for the optimized sample of MET-CS-AlgNPs showed a 70.2% weight loss compared to 55.3% for CS-AlgNPs, and the difference is due to the incorporation of MET in the CS-AlgNPs for the formation of MET-CS-AlgNPs nanocomposites. The release of MET from the nanocomposite showed sustained-release properties, indicating the presence of an interaction between MET and the polymer. The nanocomposite shows a smooth surface and spherical shape. The release profile of MET from its MET-CS-AlgNPs nanocomposites was found to be governed by the second kinetic model (R2 between 0.956–0.990) with more than 90% release during the first 50 h, which suggests that the release of the MET drug can be extended or prolonged via the nanocomposite formulation.

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Section: Thermogravimetric Analysis Of Met-cs-algnps Nanocompositesmentioning

confidence: 99%

A Statistical Study on the Development of Metronidazole-Chitosan-Alginate Nanocomposite Formulation Using the Full Factorial Design

et al. 2020

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“…The presence of PAA was confirmed by -COOH (carboxylic acid group) and -OH (hydroxyl group) stretching vibrations at 1700 and 3400 cm −1 , respectively [27,31]. New peaks from the nitrite group of MD/PAA were observed at 1363 and 1541 cm −1 due to the presence of MD [30]. The peak intensity of N=O stretching and the imidazole ring was increased with the MD concentration (from 0 to 1 wt%).…”

Section: Characterization Of Md/paamentioning

confidence: 94%

“…When the radiation dose was increased, the degradation of MD was greater. Radiolysis or UV-photolysis can break down N=O groups and imidazole rings of MD [30]. In addition, when UV-photolysis was used, the degradation levels of N=O groups and imidazole rings of MD increased with increased time and light intensity, relative to the degradation by non-radiation exposed UV-photolysis [31].…”

Section: Characterization Of Iradiated MDmentioning

confidence: 99%

“…The released hydrogen radical (H•) combined with H• from water, leading to the evolution of hydrogen gas. In addition, the free radical of PAA was able to cross-link with other PAA molecules, resulting in the formation of PAA hydrogel films [30]. The overall reaction mechanism of MD/PAA is shown in Figure 4.…”

Section: Characterization Of Md/paamentioning

confidence: 99%

“…The MD/PAA hydrogel films were dried at room temperature. The MD was released in PBS (pH 7.4) to identify cumulative release of MD with different times (10,20,30,40,50,60, and 120 min) using UV spectroscopy and absorbance at 319 nm. The MD/PAA25 with different concentration of MD were investigated and are shown in Figure 10.…”

Section: Release Test Of Md/paamentioning

confidence: 99%

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Preparation of Radiation Cross-Linked Poly(Acrylic Acid) Hydrogel Containing Metronidazole with Enhanced Antibacterial Activity

Jeong

Park

Kim

et al. 2019

IJMS

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Metronidazole (MD) is known as a periodontitis medicine and has been widely used in antibiotics for resistance to anaerobic bacteria, periodontal disease, and other threats. To treat diseases, drug delivery carriers are needed with a high bioadhesive property and enhanced drug penetration. Poly (acrylic acid) (PAA) hydrogel films have a good bioadhesive property and are able to localize the absorption site and increase the drug residence time. In this study, we fabricated a MD loaded PAA hydrogel with different MD content (0.1, 0.25, 0.5, and 1 wt%) using varying doses (25, 50, and 75 kGy) and the radiation doses (25, 50, or 75 kGy) in a one-step gamma-ray irradiation process. The chemical and physical structure were determined through a Fourier transformed infrared spectroscopy, X-ray photoelectron spectroscopy, gel content, and compressive strength. In addition, MD loaded PAA hydrogels were performed to MD release behaviors and cytotoxicity. Finally, we conducted antibacterial activity to demonstrate the prevention of growth of bacteria as a therapeutic dressing. The basic chemical structure analysis of MD was changed greatly at radiation doses of 50 and 75 kGy due to degradation by gamma-ray irradiation. However, when the absorbed dose was 25 kGy, the chemical structure analysis of MD did not change significantly, and the gel content and compressive strength of MD/PAA hydrogel were approximately 80% and 130 kPa, respectively. The MD/PAA hydrogels exhibited no cytotoxicity and good antibacterial activity against Escherichia coli, Staphylococcus aureus, and Streptococcus mutans. These results provide good evidence that MD/PAA hydrogel prepared by gamma-ray irradiation has potential as a competitive candidate for the therapeutic dressing.

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Application of multiple regression analysis in optimization of metronidazole-chitosan nanoparticles

et al. 2019

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Cited by 30 publications

References 11 publications

A Statistical Study on the Development of Metronidazole-Chitosan-Alginate Nanocomposite Formulation Using the Full Factorial Design

A Statistical Study on the Development of Metronidazole-Chitosan-Alginate Nanocomposite Formulation Using the Full Factorial Design

Preparation of Radiation Cross-Linked Poly(Acrylic Acid) Hydrogel Containing Metronidazole with Enhanced Antibacterial Activity

Application of multiple regression analysis in optimization of metronidazole-chitosan nanoparticles

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