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Pak, Brian J.; Chu, Wendy; Lu, Shi Jiang; Kerbel, Robert S.; Ben‐David, Yaacov

doi:10.1023/a:1013175516793

Cited by 25 publications

(10 citation statements)

References 45 publications

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“…Recently, there were some reports that TRP-2 overexpression was associated specifically with resistance to DNA-damaging drugs and radiation treatment (Chu et al, 2000;Pak et al, 2000Pak et al, , 2001Pak et al, , 2004. We also reported recently that compared to patients receiving either chemotherapy or vaccinations alone, glioblastoma patients who received chemotherapy after active immunological DC-based vaccination experienced slower tumor progression and longer survival times .…”

Section: Introductionmentioning

confidence: 77%

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Cytotoxic T cell targeting of TRP-2 sensitizes human malignant glioma to chemotherapy

et al. 2005

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Tyrosinase-related protein (TRP)-2 is not only expressed on glioma cells, but is naturally processed and presented by their surface MHC molecules and is recognized by TRP-2-specific cytotoxic T cells. After active immunotherapy, we detected TRP-2-specific cytotoxic T lymphocyte (CTL) activity in patients' peripheral blood mononuclear cells (PBMC). Tumor cells from postvaccination resections showed significantly lower TRP-2 expression and higher sensitivity to carboplatin and temozolomide than those autologous cell lines from prevaccination resections in two patients who demonstrated CTL response to TRP-2. One of two patients underwent treatment with temozolomide after recurrence and responded dramatically. TRP-2-transfected cell line (TRP-2-U373) resulted in significant drug resistance to carboplatin and temozolomide compared to wild-type U-373 (W-U373). There was no significant difference, however, in the mRNA expression of other common drug resistance related proteins, such as BCRP-1, MGMT, MDR-1, MRP-1 and MRP-3, after TRP-2 transfection. TRP-2-U373 tumor cells were immunoselected by a TRP-2-specific CTL line. The immunoselected cells (IS-TRP-2-U373) demonstrated significantly increased sensitivity to carboplatin and temozolomide compared to TRP-2-U373. For the first time, we provide evidence that immunological targeting of tumor-associated antigen TRP-2 significantly increases sensitivity to chemotherapy.

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Section: Introductionmentioning

confidence: 77%

“…TRP-2 overexpression has been shown to mediate resistance to treatments that evoke DNA damage (Chu et al, 2000;Pak et al, 2001). Melanoma cells that overexpressed TRP-2 generated resistance not only to chemotherapeutic drugs but also to X-ray-and ultraviolet (UV)-radiation-induced apoptosis (Nishioka et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic T cell targeting of TRP-2 sensitizes human malignant glioma to chemotherapy

et al. 2005

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“…Tyrosinase, TRP-1, as well as TRP-2 are melanogenesis enzymes which mediate the conversion of L-tyrosine to melanin. In particular, TRP-2 has been reported to be abundantly expressed in most tumors and melanoma cell lines (Pak, Chu, Lu, Kerbel, & Ben-David, 2001). It has been reported that some phenolic depigmenting compounds are not only tyrosinase inhibitors, but also agents that decreased MITF production with synergistic effects on melanogenesis (Solano, Briganti, Picardo, & Ghanem, 2006 also be beneficial to human skin (Lephart, Sommerfeldt, & Andrus, 2014).…”

Section: Discussionmentioning

confidence: 99%

Oxyresveratrol and trans-dihydromorin from the twigs of Cudrania tricuspidata as hypopigmenting agents against melanogenesis

Zheng

Zhang

et al. 2015

Journal of Functional Foods

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“…32) Therefore, 2,3-dihydro-4Ј,4ٞ-di-O-methylamentoflavone (5) is believed to affect the cytotoxicity of melanogenic intermediates in melanocytes, 33) which may therefore reduce pigment production. The pigment-related gene expression of this compound was also evaluated.…”

Section: The Effects Of Anti-tyrosinase Activities and Melanin Inhibimentioning

confidence: 99%

New Constituent from Podocarpus macrophyllus var. macrophyllus Shows Anti-tyrosinase Effect and Regulates Tyrosinase-Related Proteins and mRNA in Human Epidermal Melanocytes

Cheng

Hsu

Chen³

et al. 2007

CHEMICAL & PHARMACEUTICAL BULLETIN

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A new biflavonoid, 2,3-dihydro-4,4ٟ-di-O-methylamentoflavone (5), and five known compounds, (؊)-catechin (1), quercetin (2), 2,3-dihydrosciadopitysin (3), sciadopitysin (4), and isoginkgetin (6), were isolated from Podocarpus macrophyllus var. macrophyllus (Podocarpaceae). These compounds were evaluated their ability to inhibit cellular tyrosinase activity and for their melanin inhibitory activity in human epidermal melanocytes (HEMn). In the melanin synthesis assay, 2,3-dihydro-4,4ٟ-di-O-methylamentoflavone (5) showed a potent antityrosinase effect with IC 50 ‫890.0؍‬ mM in HEMn. It also significantly decreased both protein and mRNA levels of the tyrosinase-related protein-2 (TRP-2) by Western blot and quantitative real-time PCR (qRT-PCR) analysis. These findings suggest that the new compound, 2,3-dihydro-4,4ٟ-di-O-methylamentoflavone (5), is the most active component of P. macrophyllus var. macrophyllus in inhibiting pigmentation and that this inhibition is exerted through inhibition of transcription of the genes encoding TRP2.

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Untitled

Cited by 25 publications

References 45 publications

Cytotoxic T cell targeting of TRP-2 sensitizes human malignant glioma to chemotherapy

Cytotoxic T cell targeting of TRP-2 sensitizes human malignant glioma to chemotherapy

Oxyresveratrol and trans-dihydromorin from the twigs of Cudrania tricuspidata as hypopigmenting agents against melanogenesis

New Constituent from Podocarpus macrophyllus var. macrophyllus Shows Anti-tyrosinase Effect and Regulates Tyrosinase-Related Proteins and mRNA in Human Epidermal Melanocytes

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