Untitled

Wikberg, Martin; Alderborn, Göran

doi:10.1023/a:1018929214629

Cited by 32 publications

(3 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In compaction studies using granules made by wet massing-screen procedures, Wikberg and Alderborn (2,4) proposed that the increase in granule porosity might increase the degree of fragmentation propensity, i.e., the tendency for particles to break-down or collapse during the compression phase. This had previously been shown to be important in the consolidatiorddeformation mechanisms for materials such as Emcompress@, saccharose and lactose (34) and the granulations from which they were made.…”

Section: Indentation Hardnessmentioning

confidence: 99%

Compaction Properties of Spheronized Binary Granular Mixtures

Wang

Zhang

Shah

et al. 1995

Drug Development and Industrial Pharmacy

View full text Add to dashboard Cite

Two spheronized granular formulations containing 20% anhydrous lactose/80% microcrystalline cellulose (MCC) and 80% anhydrous lactoseRO% microcrystalline cellulose were blended in various proportions and compressed. Physicalmechanical properties of the resulting compacts were investigated using tableting indices and compared with powder mixtures of the same compositions. The compacts were compressed at a solid fraction of 0.80 for both powder and bead mixtures. An additional set of bead compacts were made at a solid fraction of 0.87. The thickness of the compacts was measurcd in the post-ejection stage to investigate their expansion behavior. The tensile strength with and without a stress concentrator and the dynamic indentation hardness of the compacts were determined. The brittle fracture index (BFI) and bonding index (BI) values were also calculated. The microstructure of the beads and compacts were investigated using scanning electron microscopy to observe the bonding phenomena. The results showed that the compacts made fro-beads underwent different 753 Copyright 0 1995 by Marcel Dekker, Inc. Drug Dev Ind Pharm Downloaded from informahealthcare.com by QUT Queensland University of Tech on 11/21/14 For personal use only. important factor for tablet strength and may be related to the precompaction granule porosity. Healey et al. (5) concluded that the effect of the granule porosity was not important except at low pressure. The influence of other parametcrs, including the homogeneity of binder distribution (6), the particle size of powder and binder Drug Dev Ind Pharm Downloaded from informahealthcare.com by QUT Queensland University of Tech on 11/21/14 For personal use only.

show abstract

Section: Indentation Hardnessmentioning

confidence: 99%

Compaction Properties of Spheronized Binary Granular Mixtures

Wang

Zhang

Shah

et al. 1995

Drug Development and Industrial Pharmacy

View full text Add to dashboard Cite

show abstract

“…Furthermore, granulating solvent significantly affects the granule properties. Changing the solvent system leads to a change in wettability and solubility of formulation constituents, and thus influences binder distribution, which in turn affects the granule strength and porosity (Wikberg and Alderborn, 1993, Shah et al, 1996). In the pharmaceutical industry aqueous, hydro-alcoholic, and alcoholic solvent systems are widely used.…”

Section: Introductionmentioning

confidence: 99%

Investigate the effect of solvents on wet granulation of microcrystalline cellulose using hydroxypropyl methylcellulose as a binder and evaluation of rheological and thermal characteristics of granules

Tank

Karan

Gajera

et al. 2018

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

Wet granulation is the most commonly used technique in the pharmaceutical industry for delivering oral solid dosage forms. In wet granulation, the binder solvent is one of the critical factors affecting granule properties. In the current study, an attempt was made to investigate the effect of solvents (aqueous and hydro-alcoholic) on thermal and flow properties of Microcrystalline Cellulose (MCC) granules prepared using two different grades of Hydroxypropyl Methylcellulose (HPMC), which served as an effective binder. The granulation endpoint was evaluated using thermal effusivity sensor. Rheometer and Modulated Differential Scanning Calorimetry (mDSC) was used to study the flow and thermal properties of wet and dried granules. Furthermore, physical characterization was carried out by granule strength, particle size distribution and tablet hardness for all granules under the study. Thermal effusivity sensor results indicate 55% w/w concentration of binder solution as the endpoint by measuring thermal effusivity for both binders. Additionally, powder rheometer results show that the wet granules of hydro-alcoholic batches show greater resistance to flow whereas the dried granules display excellent flow characteristics as evident from Basic flowability energy values and specific energy values. Permeability results suggest that the granules formed with hydro-alcoholic binder solvent exhibit better porosity and permeability. Tablet hardness data showed that tablets formulated using hydro-alcoholic solvent granules have greater hardness than tablets formulated using water based solvent granules. The granule strength for water based granules is relatively higher than that of hydro-alcoholic based granules. mDSC thermograms show a sharp rise in enthalpy value at 55% w/w binder solution which is indicative of a more significant amount of solvent being present on the surface of granules and formation of optimal granules. To summarize, we have determined a technique to measure endpoint determination and simultaneously investigate the role of solvent systems on the rheology of MCC granules, which could assist in selecting an appropriate solvent system for granulation.

show abstract

“…1,2) Often, the properties of the granules have been found to influence the quality of the final product. [3][4][5] Thus, it is crucial that the drying method be controlled to assure that it does not adversely affect the quality of the final product.…”

mentioning

confidence: 99%

Microwave Drying of Granules Containing a Moisture-Sensitive Drug: A Promising Alternative to Fluid Bed and Hot Air Oven Drying

Chee

Johansen

et al. 2005

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

Wet granulation technique is often employed in the preparation of free flowing agglomerates. It is essential that the agglomerates/granules produced were suitably dried prior to further processing such as tabletting, capsule or sachet filling. The drying process can have an impact on the final properties of granules and it has been reported that solute migration, overheating and structural damages of granules were not uncommon in conventional drying methods. 1,2) Often, the properties of the granules have been found to influence the quality of the final product.3-5) Thus, it is crucial that the drying method be controlled to assure that it does not adversely affect the quality of the final product.Common drying methods used in the pharmaceutical industry include hot air oven drying and fluid bed drying. These methods employ different modes of moisture removal and differ in drying capability. In recent years, microwave drying has gained greater interest. The moist material is subjected to the high frequency electromagnetic waves that selectively excite the polar molecules (dipoles) and ions causing them to align with the rapidly alternating electric field. Heat (dielectric heating) will be generated during the orientation of these dipoles and ions that in turn evaporates the moisture present in the material. Thus, a pressure gradient is created and it promotes the rapid removal of liquid water and water vapour towards the surface of the material.6-9) Basically, the principle of dielectric heating involves the absorption of energy by dipoles and the energy absorbed is given by:where P ϭenergy absorbed f ϭmicrowave frequency E ϭelectric field E 0 ϭdielectric constant of vacuum E r ϭdielectric constant of material tan dϭloss tangent tan d can be regarded as a measure of the molecular interaction. The product of the dielectric constant, E r and tan d is the loss factor and it determines the energy absorbed and thus the heating rate. McLoughlin and other coworkers found that the moisture content variation within the material undergoing drying with microwave was lower than a conventionally dried product. 8) Thus, microwave drying is especially useful for moisture-sensitive materials.In addition, the microwave drying technology is useful for production of very high potency dosage forms because it provides the possibility of drying in the same production container. Thus, it reduces the likelihood of cross contamination and human contact with the high potency drug. Furthermore, such a single-pot process also reduces the number of equipment used for production and its associated cleaning and validation activities.Various authors have investigated the influence of equipment parameters and the effects of dielectric properties of materials in microwave drying. 8,10,11) It was reported that localised heating could arise in microwave drying and be overcome with bed agitation. With respect to the influence on granular properties, Mandal found that microwave radiation did not modify the surface properties and dissolution rates of...

show abstract

Untitled

Cited by 32 publications

References 2 publications

Compaction Properties of Spheronized Binary Granular Mixtures

Compaction Properties of Spheronized Binary Granular Mixtures

Investigate the effect of solvents on wet granulation of microcrystalline cellulose using hydroxypropyl methylcellulose as a binder and evaluation of rheological and thermal characteristics of granules

Microwave Drying of Granules Containing a Moisture-Sensitive Drug: A Promising Alternative to Fluid Bed and Hot Air Oven Drying

Contact Info

Product

Resources

About