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Stuppner, Hermann; Ellmerer, Ernst P.; Ongania, Karl‐Hans; Dobner, Michael J.

doi:10.1002/1522-2675(200209)85:9<2982::aid-hlca2982>3.0.co;2-h

Cited by 18 publications

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“…Even though most of the detected compounds could be identified with a high degree of certitude, ten compounds remain unidentified. Most of these do not possess any similarity (molecular ion or fragment ions) with other compounds reported in the composition of L. alpinum , such as terpenes [ 9 , 10 , 11 ], lignans [ 25 ], or flavonoids [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

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Profiling of Polyphenolic Compounds of Leontopodium alpinum Cass Callus Cultures Using UPLC/IM-HRMS and Screening of In Vitro Effects

Pralea

Moldovan

Țigu

et al. 2021

Plants

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Leontopodium alpinum Cass. (edelweiss) is recognized as a frequent constituent of anti-aging skin care products, providing increased antioxidant and anti-inflammatory defense. Considering the growing demand and the protected status of edelweiss in many countries, alternative methods of production have been developed, one of them being callus culturing. This study reports the phytochemical composition of a methanolic extract of L. alpinum callus cultures, characterized by liquid chromatography coupled to ion-mobility high resolution mass spectrometry (UPLC/IM-HRMS). The methanolic extract exhibited strong free radical scavenging activity (122.19 ± 7.28 mg AAE/g dw), while the quantitative evaluation revealed that four major constituents (phenylpropanoid derivatives) represent 57.13% (m/m) of the extract. Consequently, a screening of antiproliferative effects was performed on ten cancer cell lines, representative of prostate, colon, lung and breast cancer, showing inhibition of colony formation in all cases. These results provide a comprehensive phytochemical characterization of L. alpinum callus cultures using advanced IM-HRMS, while the in vitro explorations confirmed the potent antioxidant properties of edelweiss which are worth exploring further in cancer prevention.

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Section: Discussionmentioning

confidence: 99%

“…Previous investigations [ 6 , 7 , 8 , 9 , 10 , 11 , 12 ] of Leontopodium alpinum phytochemical composition highlighted a number of compound classes, such as phenylpropanoid, sesquiterpene, benzofuran and lignan derivatives. However, data regarding the composition of callus cultures is rather limited [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Profiling of Polyphenolic Compounds of Leontopodium alpinum Cass Callus Cultures Using UPLC/IM-HRMS and Screening of In Vitro Effects

Pralea

Moldovan

Țigu

et al. 2021

Plants

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“…67 A new bisabolane sesquiterpene 46 has been isolated from an Okinawan sponge of the Axinyssa genus. 68 The bisabolane derivatives 47-50 and 51 have been isolated from the roots of Leontopodium alpinum 69 and from the stems of Machilus zuihoensis, 70 respectively. Microbiological and chemical transformations of the bioactive marine sesquiterpene (S )-(ϩ)-curcuphenol and (S )-(ϩ)-curcudiol have been carried out.…”

Section: Bisabolane and Heliannanementioning

confidence: 99%

Natural sesquiterpenoids

Fraga

2003

Nat. Prod. Rep.

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New Bisabolane Sesquiterpenes and Coumarin from Leontopodium longifolium

Lin

Yang

et al. 2006

Chemistry & Biodiversity

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From the roots of Leontopotium longifolium, three new bisabolane sesquiterpenes, rel-(1S,4R,5S,6R)-4,5-diacetoxy-6-[(R)-1,5-dimethylhexa-3,5-dienyl]-3-methylcyclohex-2-enyl (Z)-2-methylbut-2-enoate (1), rel-(1S,4R,5S,6R)-4,5-diacetoxy-6-[(R)-5-hydroxy-1,5-dimethylhex-3-enyl]-3-methylcyclohex-2-enyl (Z)-2-methylbut-2-enoate (2), rel-(1R,2S,4R,5S)-4-acetoxy-2-[(R)-5-hydroxy-1,5-dimethylhex-3-enyl]-5-methylcyclohexyl (Z)-2-methylbut-2-enoate (3), and a new coumarin, 2,3-dihydro-5-hydroxy-2-(1-methylethenyl)-7H-pyrano[2,3-g][1,4]benzodioxin-7-one (4) together with nine known compounds have been isolated. The structures of these compounds were established by spectroscopic methods. Compounds 1 and 2 exhibited moderate cytotoxic activities against human promyelocytic leukemia (HL-60) cells.

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Cited by 18 publications

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Profiling of Polyphenolic Compounds of Leontopodium alpinum Cass Callus Cultures Using UPLC/IM-HRMS and Screening of In Vitro Effects

Profiling of Polyphenolic Compounds of Leontopodium alpinum Cass Callus Cultures Using UPLC/IM-HRMS and Screening of In Vitro Effects

Natural sesquiterpenoids

New Bisabolane Sesquiterpenes and Coumarin from Leontopodium longifolium

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