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Miguel, Ignacio de; Imbertie, Laurent; Rieumajou, Valérie; Major, M; Kravtzoff, Roger; Betbeder, Didier

doi:10.1023/a:1007504124603

Cited by 70 publications

(31 citation statements)

References 14 publications

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“…The proposed reaction mechanism of ECH with CMC is shown in Figure 1. ECH was widely used as a crosslinker to react with the hydroxyl groups of polysaccharide 25–30. In alkaline conditions, the hydroxyl groups of CMC become alcoholate anion.…”

Section: Resultsmentioning

confidence: 99%

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Hydrogel beads based on carboxymethyl cellulose for removal heavy metal ions

Yang

Liu

et al. 2010

J of Applied Polymer Sci

171

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Environment-friendly carboxymethyl cellulose (CMC) hydrogel beads were successfully prepared using epichlorohydrin (ECH) as a crosslinking agent in the suspension of fluid wax. There was an ether linkage formed between ECH and CMC, which was identified from bands in FTIR spectra of the prepared hydrogel. The prepared hydrogel beads with diameters about 4 mm were apparently spherical and fully transparent. The X-ray diffraction (XRD) spectra indicated that the adsorption of metal ion onto the oxygen atom of carboxyl group led to change in crystallinity patterns of hydrogels. The scanning electron microscope (SEM) images clearly showed that the hydrogels had an internal porous structure. The adsorption capacity increased as initial concentrations of metal ions and the pH value of metal ion solution increased. Freundlich and Langmuir isotherm models were employed to analyze the data from batch adsorption experiments. There are vey good correlation coefficients of linearized equations for Langmuir model, which indicated that the sorption isotherm of the hydrogel beads for metal ions can be fitted to the Langmuir model. The maximum adsorption amount of hydrogel beads for metal ions is 6.49, 4.06, and 5.15 mmol/g for Cu(II), Ni(II), and Pb(II), respectively.

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Section: Resultsmentioning

confidence: 99%

“…The alcoholate anion attacks the epoxy groups of ECH to form a monoether of chloropropanediol 25, 26. A new epoxy group will yield by chloride displacement rearranges of the chloropropanediol monoether 30. When the new epoxy groups react with the hydroxyl groups of another CMC, the crosslinking reaction occurs between ECH and CMC.…”

Section: Resultsmentioning

confidence: 99%

Hydrogel beads based on carboxymethyl cellulose for removal heavy metal ions

Yang

Liu

et al. 2010

J of Applied Polymer Sci

171

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“…The hybrid NPs can be a robust drug delivery platform with high drug encapsulation yield, tunable and sustained drug release profile, excellent serum stability, and potential for differential targeting of cells or tissues. Previously polymeric NPs were mixed with liposomes to form lipid-polymer complexes such as lipoparticles where the lipid bilayer or lipid multi-layer fuses on the surface of polymeric NPs 14–16 . These complexes usually require a two-step formulation process: i) development of polymeric NPs, and ii) encapsulation of polymeric NPs within liposomes, resulting in a poor control over the final NP physicochemical structure which may hinder their clinical translation.…”

Section: Introductionmentioning

confidence: 99%

Self-Assembled Lipid−Polymer Hybrid Nanoparticles: A Robust Drug Delivery Platform

et al. 2008

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We report the engineering of a novel lipid-polymer hybrid nanoparticle (NP) as a robust drug delivery platform, with high drug encapsulation yield, tunable and sustained drug release profile, excellent serum stability, and potential for differential targeting of cells or tissues. The NP is comprised of three distinct functional components: i) a hydrophobic polymeric core where poorly water-soluble drugs can be encapsulated; ii) a hydrophilic polymeric shell with anti-biofouling properties to enhance NP stability and systemic circulation half-life; and iii) a lipid monolayer at the interface of the core and the shell that acts as a molecular fence to promote drug retention inside the polymeric core, thereby enhancing drug encapsulation efficiency, increasing drug loading yield, and controlling drug release. The NP is prepared by self-assembly through a single-step nanoprecipitation method in a reproducible and predictable manner, making it potentially suitable for scale-up

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“…23, 24 Polymeric NPs have been mixed with liposomes to form lipid-polymer complexes such as lipoparticles where the lipid bilayer or lipid multilayer fuses on the surface of polymeric NPs. 25 These complexes usually require a two-step formulation process: 1) development of polymeric NPs, and 2) encapsulation of polymeric NPs within liposomes.…”

mentioning

confidence: 99%

Delivery of Multiple siRNAs Using Lipid-Coated PLGA Nanoparticles for Treatment of Prostate Cancer

Hasan¹,

Chu²,

Gullapalli³

et al. 2011

Nano Lett.

167

112

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Nanotechnology can provide a critical advantage in developing strategies for cancer management and treatment by helping to improve the safety and efficacy of novel therapeutic delivery vehicles. This paper reports the fabrication of poly(lactic acid-co-glycolic acid)/siRNA nanoparticles coated with lipids for use as prostate cancer therapeutics made via a unique soft lithography particle molding process called PRINT (Particle Replication In Nonwetting Templates). The PRINT process enables high encapsulation efficiency of siRNA into neutral and monodisperse PLGA particles (32–46% encapsulation efficiency). Lipid-coated PLGA/siRNA PRINT particles were used to deliver therapeutic siRNA in vitro to knockdown genes relevant to prostate cancer.

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Abstract: Results show that in case of SMBV lipids are strongly adsorbed on the polysaccharide core surface probably due to ionic/hydrophobic interactions. The resulting supramolecular structure is a spherical cationic polysaccharide particle surrounded by a phospholipid/cholesterol layer.

Cited by 70 publications

References 14 publications

Hydrogel beads based on carboxymethyl cellulose for removal heavy metal ions

Hydrogel beads based on carboxymethyl cellulose for removal heavy metal ions

Self-Assembled Lipid−Polymer Hybrid Nanoparticles: A Robust Drug Delivery Platform

Delivery of Multiple siRNAs Using Lipid-Coated PLGA Nanoparticles for Treatment of Prostate Cancer

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