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Synthesis, characterization and antifungal activity of new dithiocarbamate-based complexes of Ni(II), Pd(II) and Pt(II)

“…Pt(II) and Pd(II) are less studied. However, the antitumor properties and the cytotoxic activity of platinum and palladium DTCs have been mentioned towards a series cell samples [8], and in some experiments they showed higher anticancer activity and lower toxicity than cisplatinum or similar complexes [19].…”

“…Pt(II) and Pd(II) are less studied. However, the antitumor properties and the cytotoxic activity of platinum and palladium DTCs have been mentioned towards a series cell samples [8], and in some experiments they showed higher anticancer activity and lower toxicity than cisplatinum or similar complexes [19].In view of the growing cases of drug resistance of micro-organisms it is urgent the search for more bio-specific antifungal agents, less toxic to the host and environment. Metal-based drugs might answer this claim, representing an alternative therapeutic route.…”

Synthesis, characterization and in vitro cytotoxicity of palladium(II) complexes with mixed ligands. X‐ray diffraction study of C31H36ClNPPdS2

“…38 In the reported Pd(II) complexes 1-6, there were significant downfield chemical shifts of the cyclohexyl proton (range 0.07-5.18 ppm) that also support the complexation and this shift being due to steric interactions/coordination between dicyclohexyldithiocarbamate ligand and the bulky PdCl 2 PPh 3 group. 39 In the 13 C NMR spectra, the number of the signals found corresponds with the presence of magnetically nonequivalent carbon atoms, which were assigned by comparison with literature values. 38 The resonance of the C S carbon at δ (192.6-196.6 ppm) in the free ligands was shifted downfield to 204.5-207.6 ppm due to a strong de-shielding effect on this particular carbon atom after complexation.…”

“…14 In our previous work, we have studied the coordination behavior of dithiocarbamate, as an extension of this research work and in connection with our current interest in the coordination chemistry and anti-cancer activity of palladium(II) complexes with mixed ligands. We have selected the two ligands, N,Ndicyclohexyldithiocarbamate (DCHDTC) and N-methyl-Ncyclohexyldithiocarbamate (MCHDTC), and synthesized a series of complexes, Pd(L)(PR 3 )Cl (L = DCHDTC, MCHDTC; R = Ph, o-tolyl, ClPh 2 ), and characterized them by elemental analyses, FT-IR, multinuclear ( 1 H, 13 C and 31 P) NMR and single X-ray crystallography.…”

“…9,14 Several Pt and Pd complexes with dithiocarbamates and dithioesters are known to exhibit cytotoxic activity against some cancers, such as lungs cells, ovarian, 10 melanoma, colon, 11 renal, prostate 12 and breast cancer. 13 In order to explore the scope, nature of bonding and coordination modes of cyclic ambidentate dithiocarbamate …”