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Kankkunen, Tarja; Sulkava, Raimo; Vuorio, Marja; Kontturi, Kyösti; Hirvonen, Jouni

doi:10.1023/a:1015374600683

Cited by 54 publications

(9 citation statements)

References 10 publications

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“…A forming of drug reservoir was offered by the ion-exchange and was kept inside until they are released by the mobile ions which from the iontophoresis system. [21] The result showed that with the support from iontophoresis system, the delivery of active ingredients was well controlled to the steady state of about 14.9 ± 2.6 ng/ml in human beings until the device was turned off. [21] Subsequently, delivery parameters for iontophoresis were reported by Upasani and Banga in 2004.…”

Section: Transdermal For Alzheimer's Diseasementioning

confidence: 99%

“…[21] The result showed that with the support from iontophoresis system, the delivery of active ingredients was well controlled to the steady state of about 14.9 ± 2.6 ng/ml in human beings until the device was turned off. [21] Subsequently, delivery parameters for iontophoresis were reported by Upasani and Banga in 2004. Iontophoresis is a complex process which is affected by many factors such as drug concentration, molecular size, and strength of the donor buffer and electrical factors such as current density and mode.…”

Section: Transdermal For Alzheimer's Diseasementioning

confidence: 99%

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Current advances in transdermal delivery of drugs for alzheimer's disease

Nguyen

Giau

Vo³

2017

Indian J Pharmacol

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Section: Transdermal For Alzheimer's Diseasementioning

confidence: 99%

Section: Transdermal For Alzheimer's Diseasementioning

confidence: 99%

Current advances in transdermal delivery of drugs for alzheimer's disease

Nguyen

Giau

Vo³

2017

Indian J Pharmacol

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“…Fibrous ion‐exchange materials are suggested to have a larger surface area to unit volume ratio, which leads to a higher absorption rate and absorption capacity as compared with the resin. Information about the research on ion‐exchange fibers has been published mostly in China, Japan, and in Eastern European countries 4–7…”

Section: Introductionmentioning

confidence: 99%

Pegylated liposomal doxorubicin and gemcitabine in patients with advanced hepatocellular carcinoma

Lombardi

Zustovich

Farinati

et al. 2010

Cancer

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BACKGROUND: Over the years, doxorubicin and gemcitabine have been among the most widely used drugs for hepatocellular carcinoma (HCC), with relative efficacy. The authors report the results of a phase 2 study of the combination of gemcitabine plus pegylated liposomal doxorubicin. METHODS: Patients with advanced HCC received combination chemotherapy with gemcitabine 1000 mg/m 2 on Days 1 and 8, followed by pegylated liposomal doxorubicin 30 mg/m 2 on Day 1. Treatment was repeated every 4 weeks to a maximum of 8 cycles. Primary endpoint was overall response rate, and secondary endpoints were time to disease progression (TTP), overall survival (OS), and toxicity. RESULTS: Forty-one patients were enrolled and were evaluable for response, toxicity, and survival. A total of 194 cycles of treatment were administered. Three (7%) patients had a complete response, and 1 of these patients underwent liver transplantation. Seven (17%) patients had a partial response and, among these patients, 1 patient underwent surgical resection. Among the 31 patients who had initial alpha-fetoprotein levels >400 ng/mL, 20 (64.5%) had a >20% decrease after 2 cycles of treatment. The median TTP and OS were 5.8 and 22.5 months, respectively. Hematologic toxicity was the most common side effect, including neutropenia (17%) and anemia (7%). CONCLUSIONS: The combination of gemcitabine plus pegylated liposomal doxorubicin was active and safe in advanced HCC. Moreover, this treatment induced some complete responses and converted some untreatable HCCs into lesions eligible for resection or transplantation. Cancer 2011;117:125-33.

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“…Information about the research on ion-exchange fibers has been published mostly in China, Japan, and in Eastern European countries. [4][5][6][7] Our research, in recent years, is directed toward obtaining biologically activate fibers in the form of complex ion-exchange fibers-insulin as an artificial store of insulin. The fibrous ion exchangers are relatively new materials.…”

Section: Introductionmentioning

confidence: 99%

Mathematical modeling of insulin sorption by ion‐exchange fiber

Medovic¹,

Škundrić

Pajić‐Lijaković

et al. 2007

J of Applied Polymer Sci

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The objective of this study was to investigate the phenomenon and kinetics of insulin chemisorption by cation-exchange acrylic fibers, as well as the development of theoretical modeling of the chemisorption process. Change of the insulin concentration in solution was determined by UV spectrophotometric method. The profile of insulin concentration in the fiber was determined by application of mathematical model. The developed mathematical model describes the chemisorption process using fractional kinetics equations of diffusion. Taking all the relevant conditions, regarding this experiment, into consideration, the coefficient of insulin diffusion into the fiber, overdamped effect parameter, as well as the concentration ratio parameter were determined by the mathematical model. Proposed modeling approach is useful for the description of transport dynamics in complex systems as polymer transport through the porous matrices, which are governed by anomalous diffusion.

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Cited by 54 publications

References 10 publications

Current advances in transdermal delivery of drugs for alzheimer's disease

Current advances in transdermal delivery of drugs for alzheimer's disease

Pegylated liposomal doxorubicin and gemcitabine in patients with advanced hepatocellular carcinoma

Mathematical modeling of insulin sorption by ion‐exchange fiber

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