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Paltieli, Y.; Eibschitz, I; Ziskind, Genia; Ohel, Gonen; Silbermann, Michael; Weichselbaum, Amnon

doi:10.1023/a:1009465900824

Cited by 99 publications

(20 citation statements)

References 15 publications

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“…Similar observation in our laboratory was found in human oviduct incubated with estradiol and high level of progesterone (Li et al 2010). This finding is consistent with the reported inhibitory effect of high progesterone levels on ciliary beating and suggests that treatment of women with high levels of progesterone in ovulation-induction cycles could be the cause of tubal pregnancy (Paltieli et al 2000). The use of specific CGRP and ADM receptor blockers showed that this stimulatory effect of ADM was mediated by a CGRP receptor.…”

Section: Discussionsupporting

confidence: 89%

Adrenomedullin increases ciliary beat frequency and decreases muscular contraction in the rat oviduct

Liao

Ho²,

Tang³

2011

Reproduction

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Our laboratory previously showed that oviduct produced the greatest amount of adrenomedullin (ADM) in the rat female reproductive tract. The aim of this study is to investigate the changes in ADM levels resulting from the contact between the sperm and the oviduct and the possible roles of ADM in ciliary beating and oviductal contractility. Oviducts from Sprague-Dawley rats removed at pre-and post-ovulatory stages were cut open longitudinally and treated with ADM and/or receptor blockers before ciliary beat frequency (CBF) was measured. The effects of sperm on ADM production and CBF in the oviduct were also determined. The contraction of the oviduct after treatment with ADM and receptor antagonists was measured using the organ-bath technique. The results showed that ADM increased the CBF in rat oviduct and this stimulating effect was blocked by the calcitonin-gene-related peptide (CGRP) receptor antagonist, hCGRP . CBF was lower in post-ovulatory than pre-ovulatory oviducts. The presence of sperm in the oviduct increased both the ADM level and CBF. ADM treatment was shown to inhibit the contractility of the oviduct by lowering the basal tone and decreasing the contraction amplitude. The ADM receptor antagonist, hADM , was effective in counteracting the relaxation effect of ADM in the oviduct. All in all, these results indicate that ADM may play a crucial role in transporting the gametes/embryos by regulating ciliary beating and muscular contraction.

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Section: Discussionsupporting

confidence: 89%

Adrenomedullin increases ciliary beat frequency and decreases muscular contraction in the rat oviduct

Liao

Ho²,

Tang³

2011

Reproduction

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“…Additionally, elevated estrogen levels were found to lead to increased uterine contractions [ 41 ]. In a laboratory setting, elevated estrogen levels increased fallopian tube ciliary beat frequency [ 42 ]. This combination of increased uterine contractibility with tubal ciliary motion may increase the risk of EP in susceptible patients.…”

Section: Discussionmentioning

confidence: 99%

Ectopic pregnancy risk factors for ART patients undergoing the GnRH antagonist protocol: a retrospective study

Weiss

Beck-Fruchter

Golan

et al. 2016

Reprod Biol Endocrinol

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BackgroundIn-vitro fertilization is a known risk factor for ectopic pregnancies. We sought to establish the risk factors for ectopic pregnancy in GnRH antagonist cycles examining patient and stimulation parameters with an emphasis on ovulation trigger.MethodsWe conducted a retrospective, cohort study of 343 patients undergoing 380 assisted reproductive technology (ART) cycles with the GnRH antagonist protocol and achieving a clinical pregnancy from November 2010 through December 2015.ResultsSignificant risk factors for ectopic pregnancy in the univariate analysis included prior Cesarean section (CS), endometriosis, mechanical factor infertility, longer stimulation, elevated estradiol and progesterone levels, GnRH agonist trigger, higher number of oocytes aspirated, and insemination technique. Independent risk factors for ectopic pregnancy in the multivariate analysis included GnRH agonist trigger, higher number of oocytes aspirated, insemination technique, and prior Cesarean section.ConclusionExcessive ovarian response, IVF (as opposed to ICSI), prior Cesarean section and GnRH agonist trigger were found to be independent risk factors for ectopic pregnancy. Caution should be exercised before incorporating the GnRH agonist trigger for indications other than preventing OHSS. When excessive ovarian response leads to utilization of GnRH agonist trigger, strategies for preventing ectopic pregnancy, such as a freeze all policy or blastocyst transfer, should be considered. Further studies should elucidate whether adjusting the luteal support can reduce the ectopic pregnancy risk.

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“…One hypothesis is conditions that delay or prevent passage of the embryo through the tube and into the uterine cavity may lead to ectopic implantation [3]. It has been proposed that an elevated progesterone concentration could theoretically impair the fallopian tube cilia motility and thus increase the risk of EP in women using a progestin-only pill [4]. Levonorgestrel (LNG), a synthetic progestogen, is effective and widely used for emergency contraception (EC) either as a single dose of 1.5 mg or in two doses of 0.75 mg with 12 hours apart [5].…”

Section: Introductionmentioning

confidence: 99%

Expressions of candidate molecules in the human fallopian tube and chorionic villi of tubal pregnancy exposed to levonorgestrel emergency contraception

Huang

Zhang

Meng

et al. 2013

Reprod Biol Endocrinol

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BackgroundCases of ectopic pregnancy (EP) following levonorgestrel (LNG) emergency contraception (EC) failure were reported, however, the effects of LNG on tubal microenvironment or chorionic villi in EP have not yet been documented.MethodsFifty-five women with tubal pregnancy were divided into two groups according to whether LNG-EC was administrated during the cycle of conception. The serum concentrations of beta-hCG, E2 and P were measured. The mRNA and protein expressions of estrogen and progesterone receptors, leukemia inhibitory factor, vascular endothelial growth factor, inducible nitric oxide synthase, and endocannabinoid receptor - CB1 in the ectopic implantation site and chorionic villi were examined.ResultsCompared to those unexposed to LNG-EC, women with tubal pregnancy exposed to LNG-EC during the cycle of conception had no statistically significances in the serum concentrations of beta-hCG, E2 P, nor in the pathological types of tubal pregnancy or the expressions of ER-alpha, PR, LIF, VEGF, iNOS and CB1.ConclusionsThe expressions of candidate molecules in the fallopian tube and chorionic villi were not altered by exposure to LNG-EC. A routine therapy with no additional intervention might thus be applied to tubal pregnancy exposed to LNG-EC.

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Abstract: Higher levels of progesterone cause ciliary dysfunction and subsequently may be a possible cause of ectopic pregnancy.

Cited by 99 publications

References 15 publications

Adrenomedullin increases ciliary beat frequency and decreases muscular contraction in the rat oviduct

Adrenomedullin increases ciliary beat frequency and decreases muscular contraction in the rat oviduct

Ectopic pregnancy risk factors for ART patients undergoing the GnRH antagonist protocol: a retrospective study

Expressions of candidate molecules in the human fallopian tube and chorionic villi of tubal pregnancy exposed to levonorgestrel emergency contraception

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