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Abstract

Osteoclasts, the major source of calcium released during bone resorption, and their precursors preosteoclasts derive from bone marrow hemopoietic stem cells, granulocyte-macrophage colony-forming units. The factors responsible for commitment of colony-forming units into osteoclast precursors remain unknown. Studies of osteoclastogenesis in cultured blood mononuclear cells from patients with hyperlipidemia accompanied by atherosclerosis and calcification of vessels revealed high content of preosteoclasts in the blood.

Detection of Circulating Stromal Stem Cells with Osteogenic Potential in the Blood of Coronary Patients by Laser Flow Cytometry

“…Previous data on the appearance of stromal CFU-F with osteogenic potential in the blood of patients with primary HLP and coronary sclerosis were confirmed by the clone method [2].…”

“…Using cultural colonyforming tests, we detected stem CFU of not only hemopoietic, but also of stromal differentiation in the population of intimal cells from intima fragments of human atheromatous aorta (autopsy material) [1,2]. Moreover, stromal CFU were found in the blood of patients with hyperlidepemia (HLP) and coronary sclerosis [2].…”

“…Using cultural colonyforming tests, we detected stem CFU of not only hemopoietic, but also of stromal differentiation in the population of intimal cells from intima fragments of human atheromatous aorta (autopsy material) [1,2]. Moreover, stromal CFU were found in the blood of patients with hyperlidepemia (HLP) and coronary sclerosis [2]. This confirmed the bone marrow origin of stem CFU detected in the intima, but was in disagreement with the common concept on the impossibility of circulation of stromal stem cells in the bloodstream, in contrast to hemopoietic cells.…”