A 1-year follow-up study on immunological changes following deep brain stimulation in patients with epilepsy

Basnyat, Pabitra; Järvenpää, Soila; Raitanen, Jani; Pesu, Marko; Kai, Li; Peltola, Jukka

doi:10.1038/s41598-021-93265-x

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…For instance, IL-1RA/IL-6 ratio was proposed as a potential biomarker for the development of hippocampal injury following febrile status epilepticus in children [30]. Recently, we measured plasma levels of IL-6 and IL-10 and their ratio in DRE patients, who were treated with deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS), and evaluated the changes in cytokine levels and their ratio during a 1-year follow-up [23]. We found out that the higher pretreatment levels of IL-6 and IL-6/IL-10 ratio subsequently decreased over time following the DBS therapy, whereas the levels of IL-10 levels increased over time following treatment with ANT-DBS.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, we found that the seizure frequency and epilepsy duration can affect the IL-10 concentration in patients with epilepsy [22]. Due to IL-6 proconvulsive and IL-10 anticonvulsive features, we have demonstrated in DRE patients with deep brain stimulation (DBS) that the IL-6/IL-10 ratio was decreased over time following the initiation of DBS therapy, suggesting that the IL-6/IL-10 ratio may reflect the balance between the proconvulsive/neurotoxic and anticonvulsive/ neuroprotective effects of these two cytokines [23].…”

Section: Introductionmentioning

confidence: 99%

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The Regulation of Plasma Interleukin-6 Levels Is Modified by Hippocampal Sclerosis and Its Lateralization in Drug-Resistant Temporal Lobe Epilepsy

Peltola

Basnyat

Liimatainen

et al. 2023

Acta Neurologica Scandinavica

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Background. Several studies have reported the association of the proinflammatory cytokine IL-6 with temporal lobe epilepsy (TLE), but the regulation of IL-6 in hippocampal sclerosis (HS) is less studied. Objectives. To analyse IL-6 levels and the IL-6/IL-10 ratio in a larger, well-characterized group of patients with drug-resistant focal epilepsy (DRE), focusing especially on TLE and TLE-associated HS. Methods. IL-6 levels were measured by ELISA in plasma in a cross-sectional cohort of 265 patients comprising TLE with HS ( n = 34 ), TLE without HS ( n = 103 ), extratemporal lobe epilepsy ( n = 92 ), and idiopathic generalized epilepsy ( n = 36 ). Results. The IL-6/IL-10 ratio was higher in TLE with HS than in TLE without HS (3.1 vs. 1.6, p = 0.042 ), whereas the median levels of IL-6 did not differ among epilepsy types. TLE without HS patients had a higher proportion of increased IL-6 levels than TLE with HS patients ( p = 0.021 ). Additionally, IL-6 levels were higher in patients with right-sided HS than in those with left lateralization (1.71 vs. 0.80 pg/mL, p = 0.04 ). In TLE with HS patients, IL-6 levels showed a negative correlation with seizure frequency during the last month ( r = − 0.342 ; p = 0.047 ), whereas in TLE without HS patients, the correlation was positive but did not reach significance ( r = 0.136 ; p = 0.169 ). Conclusion. IL-6 levels and the IL-6/IL-10 ratio are differentially regulated among patients with TLE depending on the presence of HS and its lateralization, suggesting that TLE with HS is a distinct category regarding cytokine activation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Regulation of Plasma Interleukin-6 Levels Is Modified by Hippocampal Sclerosis and Its Lateralization in Drug-Resistant Temporal Lobe Epilepsy

Peltola

Basnyat

Liimatainen

et al. 2023

Acta Neurologica Scandinavica

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“…However, immunological changes have also been described as a result of neuromodulation. More specifically, the effects of anterior thalamic nucleus DBS on plasma pro-inflammatory cytokine IL-6 and the anti-inflammatory cytokine IL-10 on a population with drug-resistant epilepsy were explored recently ( 73 ). The authors found that the IL-6/IL-10 ratio decreased significantly over time following DBS treatment and responders had an increase in IL-10.…”

Section: Discussionmentioning

confidence: 99%

Neuromodulation in new-onset refractory status epilepticus

2023

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BackgroundNew-onset refractory status epilepticus (NORSE) and its subset of febrile infection-related epilepsy syndrome (FIRES) are devastating clinical presentations with high rates of mortality and morbidity. The recently published consensus on the treatment of these conditions includes anesthetics, antiseizure drugs, antivirals, antibiotics, and immune therapies. Despite the internationally accepted treatment, the outcome remains poor for a significant percentage of patients.MethodsWe conducted a systematic review of the use of neuromodulation techniques in the treatment of the acute phase of NORSE/FIRES using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.ResultsOur search strategy brought up 74 articles of which 15 met our inclusion criteria. A total of 20 patients were treated with neuromodulation. Thirteen cases represented FIRES and in 17 cases the NORSE remained cryptogenic. Ten had electroconvulsive therapy (ECT), seven had vagal nerve stimulation (VNS), and four had deep brain stimulation (DBS); one patient had initially VNS and later DBS. Eight patients were female and nine were children. In 17 out of 20 patients, the status epilepticus was resolved after neuromodulation, while three patients died.ConclusionNORSE can have a catastrophic course and the first treatment goal should be the fastest possible termination of status epilepticus. The data presented are limited by the small number of published cases and the variability of neuromodulation protocols used. However, they show some potential clinical benefits of early neuromodulation therapy, suggesting that these techniques could be considered within the course of FIRES/NORSE.

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“…The mechanism of action of TPCS in the CNS is poorly understood. [1][2] The current hypothesis suggests that transcranial pulsed current stimulation modulates neuronal network excitability and improves or restores neuronal networks that are dysfunctional or pathologically altered, decreasing neuronal cell loss through modulation of neuronal energy metabolism. [3][4]Several studies have reported the clinically observable effects of TPCS.…”

Section: Introductionmentioning

confidence: 99%

Effects of transcranial pulsed electrical stimulation on fatigue rats

Jin

Shen²,

Li³

et al. 2022

International Conference on Biomedical and Intelligent Systems (IC-BIS 2022)

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The purpose of the present study was to identify the effects of transcranial pulsed current stimulation of the central nervous system (CNS‑TPCS) on systemic monoamine neurotransmitter changes in rats with exercise fatigue. Nine Sprague Dawley (SD) rats, of which three SD rats with CNS-TPCS, were enrolled in this pilot study. Changes in plasma dopamine (DA) and 5-hydroxytryptamine (5‑HT) levels were examined using two-way repeated measures anova at seven time points (a fixed time point after the end of the test, 7 days in a row). In the experimental group, DA levels increased significantly over time following CNS‑TPCS, and 5-HT levels increased significantly over time following CNS‑TPCS. In the observation and control groups, DA and 5-HT levels remained unchanged during the experimental. The DA levels of the control group was significantly lower than that of the experimental group and the observation group, while the 5-HT level was significantly higher than that of the experimental group and the observation group. These results suggest that the anti-fatigue properties of CNS-TPCS experimental associated with its fatigue recovery effectiveness in rats with exercise fatigue. Moreover, additional studies are essential to evaluate the potential of DA and 5-HT, and as biomarkers to evaluate the fatigue recovery response to CNS‑TPCS experimental, which could facilitate sports rehabilitation optimization.

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A 1-year follow-up study on immunological changes following deep brain stimulation in patients with epilepsy

Cited by 5 publications

References 33 publications

The Regulation of Plasma Interleukin-6 Levels Is Modified by Hippocampal Sclerosis and Its Lateralization in Drug-Resistant Temporal Lobe Epilepsy

The Regulation of Plasma Interleukin-6 Levels Is Modified by Hippocampal Sclerosis and Its Lateralization in Drug-Resistant Temporal Lobe Epilepsy

Neuromodulation in new-onset refractory status epilepticus

Effects of transcranial pulsed electrical stimulation on fatigue rats

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