A 10-Year Prospective Study of Sensorineural Hearing Loss in Children with Congenital Cytomegalovirus Infection

Foulon, Ina; Naessens, Anne; Foulon, Walter; Casteels, Anne; Gordts, Frans

doi:10.1016/j.jpeds.2007.12.049

Cited by 213 publications

(175 citation statements)

References 18 publications

Supporting

Mentioning

164

Contrasting

Unclassified

Order By: Relevance

“…12,35 Progressive deterioration of hearing was observed in 11% to 50% of cases, hearing fluctuations in 16% to 23%, and late-onset deafness in 5% to 50%. 10,12,35 In our study, hearing loss was diagnosed at a mean age of 15.4 months (SD 20.4 months) (1 child was 7 years old). This is earlier than the mean age of 22 months reported by Fowler in children symptomatic at birth.…”

Section: Audiologic Characteristicsmentioning

confidence: 83%

“…These data are consistent with those described in the literature, particularly in a prospective study investigating the incidence of CMV hearing loss over a 10-year period. 10 Some published studies have found unilateral deafness, of all degrees of severity, in 33% to 52% of cases. 12,35 Progressive deterioration of hearing was observed in 11% to 50% of cases, hearing fluctuations in 16% to 23%, and late-onset deafness in 5% to 50%.…”

Section: Audiologic Characteristicsmentioning

confidence: 98%

“…3,8 SNHL is the main sequela of this congenital infection, and also the main cause of nonhereditary congenital deafness in humans. 9 Foulon et al 10 performed a prospective study of children with congenital CMV infection and found SNHL in 21% of asymptomatic children and 33% of symptomatic children. They concluded that 22% of all infected children, irrespective of neonatal signs, had some degree of SNHL.…”

Section: What This Study Addsmentioning

confidence: 99%

See 2 more Smart Citations

Vestibular Disorders in Children With Congenital Cytomegalovirus Infection

Bernard¹,

Wiener-Vacher

Abbeele

et al. 2015

Pediatrics

View full text Add to dashboard Cite

BACKGROUND: Congenital cytomegalovirus (CMV) infection is the leading infectious cause of neurologic disabilities and sensorineural hearing loss in children. Sensorineural hearing loss prevalence in CMV suggests a viral tropism for the inner ear. Vestibular disorders induced by CMV infection are underestimated. This is the largest and most thorough study to assess the incidence of vestibular disorders and their correlation with hearing thresholds in children with CMV.

show abstract

Section: Audiologic Characteristicsmentioning

confidence: 83%

Section: Audiologic Characteristicsmentioning

confidence: 98%

Section: What This Study Addsmentioning

confidence: 99%

See 1 more Smart Citation

Vestibular Disorders in Children With Congenital Cytomegalovirus Infection

Bernard¹,

Wiener-Vacher

Abbeele

et al. 2015

Pediatrics

View full text Add to dashboard Cite

show abstract

“…[92][93][94][95][96] Regarding a possible delayed onset of hearing loss, percentages in the literature range from 0% to 50%. 3,24,27,66,67 We calculated ∼18% in the symptomatic group and ∼9% in the asymptomatic group, but in both groups there was significant heterogeneity between studies. This was also the case for progression and fluctuation of hearing loss.…”

Section: Discussionmentioning

confidence: 98%

Hearing Loss and Congenital CMV Infection: A Systematic Review

Goderis¹,

Leenheer²,

et al. 2014

View full text Add to dashboard Cite

BACKGROUND AND OBJECTIVE: Hearing loss caused by congenital cytomegalovirus (cCMV) infection was first observed in 1964. Today cCMV is the most common cause of nonhereditary sensorineural hearing loss in childhood. Our objective was to provide an overview of the prevalence of cCMV-related hearing loss, to better define the nature of cCMV-associated hearing loss, and to investigate the importance of cCMV infection in hearing-impaired children. METHODS:Two reviewers independently used Medline and manual searches of references from eligible studies and review articles to select cohort studies on children with cCMV infection with audiological follow-up and extracted data on population characteristics and hearing outcomes. RESULTS:Thirty-seven studies were included: 10 population-based natural history studies, 14 longitudinal cohort studies, and 13 retrospective studies. The prevalence of cCMV in developed countries is 0.58% (95% confidence interval, 0.41-0.79). Among these newborns 12.6% (95% confidence interval, 10.2-16.5) will experience hearing loss: 1 out of 3 symptomatic children and 1 out of 10 asymptomatic children. Among symptomatic children, the majority have bilateral loss; among asymptomatic children, unilateral loss predominates. In both groups the hearing loss is mainly severe to profound. Hearing loss can have a delayed onset, and it is unstable, with fluctuations and progression. Among hearing-impaired children, cCMV is the causative agent in 10% to 20%. Despite strict selection criteria, some heterogeneity was found between selected studies.CONCLUSIONS: This systematic review underscores the importance of cCMV as a cause of sensorineural hearing loss in childhood. Pediatrics 2014;134:972-982

show abstract

“…The babies were born with asymptomatic cCMV infection and remained asymptomatic during the follow-up examinations of 12 or more months. Dollard et al [4] in 2007 and Foulon et al [8] in 2010 reported that 13.5-21.5 % of all untreated infants with asymptomatic cCMV infection at birth will develop sequela later in life. None of the asymptomatically cCMV-infected children in our study cohort developed sequela during the follow-up.…”

Section: Treatment Groupmentioning

confidence: 99%

Use of cytomegalovirus hyperimmunoglobulin for prevention of congenital cytomegalovirus disease: a retrospective analysis

Buxmann

Stackelberg²,

Schlößer³

et al. 2012

Journal of Perinatal Medicine

View full text Add to dashboard Cite

Aims: The aim of this study was to investigate the current prenatal " off-label use " of cytomegalovirus hyperimmunoglobulin (CMV-HIG) in the prevention and treatment of congenital CMV (cCMV) infection, including the long-term outcome of the children. Methods: This retrospective observational study comprised mothers and their children, born between January 1, 2006, and October 30, 2010. Prenatal CMV-HIG was administered after diagnosis of primary CMV infection of the mother. Clinical and virological data were collected from maternal and pediatric medical and laboratory reports. Follow-up was 12 -36 months after birth. Results: Forty-two women and 43 children met the study criteria. In total, 40 mothers and six unborn infants received 115 doses of CMV-HIG. The treatment group (TG; CMV-DNA polymerase chain reaction-positive amniotic fl uid) included four mothers; the multinomial group (MG; CMV-positive mother and unknown CMV status of fetus) included 38 mothers (39 infants). For the four unborn infants in TG, CMV-HIG was administered either intraumbilically or into the amniotic fl uid; three of the four mothers received intravenous CMV-HIG. Three children in TG remained CMV-positive and were asymptomatic at birth and during follow-up. One infant in TG had symptomatic cCMV infection in utero , at birth, and during follow-up. In MG, 37 of 38 women received intravenous CMV-HIG and two of 39 infants received CMV-HIG in utero . In total, 9 (23.1 % ) of 39 children in MG were positive for cCMV (including a terminated pregnancy). All eight instances of cCMV infection at birth in MG were asymptomatic at birth and during follow-up. The fetus from the terminated pregnancy showed no sonographic symptoms of cCMV infection. No severe side effect occurred in 115 CMV-HIG applications. Conclusion: CMV-HIG was well tolerated. Compared with published untreated mother-child pairs, we observed a trend toward a smaller risk for intrauterine CMV transmission following CMV-HIG application. Signs of prenatal cCMV disease were not reversed after CMV-HIG.

show abstract

A 10-Year Prospective Study of Sensorineural Hearing Loss in Children with Congenital Cytomegalovirus Infection

Cited by 213 publications

References 18 publications

Vestibular Disorders in Children With Congenital Cytomegalovirus Infection

Vestibular Disorders in Children With Congenital Cytomegalovirus Infection

Hearing Loss and Congenital CMV Infection: A Systematic Review

Use of cytomegalovirus hyperimmunoglobulin for prevention of congenital cytomegalovirus disease: a retrospective analysis

Contact Info

Product

Resources

About