A 10-year review of pediatric uveitis at a Hispanic-dominated tertiary pediatric ophthalmic clinic

Abstract

PurposeThe aim of this study was to evaluate the characteristics and outcomes of pediatric uveitis cases at a large tertiary referral center in Dallas, TX, USA.Materials and methodsThe authors performed a retrospective chart review between 2001 and 2011 to identify children with uveitis.ResultsA total of 46 children (68 eyes) with uveitis were identified. Sixty-seven percent were Hispanic, and the mean age was 9.2 years. The majority of cases were idiopathic (74%). Anterior uveitis accounted for 42% of cases followed by intermediate uveitis/pars planitis (33%), posterior uveitis/retinitis (7%), and panuveitis (20%). Most patients were treated with corticosteroids (98% topical), 52% with systemic immunosuppression therapy, and 30% with surgery. Complications occurred in 74% of patients, with the most common complication being cataract development (26%), followed by posterior synechiae (24%). Twenty-four percent of patients had recurrences. Hispanic patients had worse visual acuities at presentation (P-value =0.073) and follow-up (P-value =0.057), compared to non-Hispanic patients.ConclusionPediatric uveitis cases seen in a large center in Dallas were largely idiopathic, had commonly developed complications, and were associated with worse visual outcomes in Hispanic patients.

Association of toll-like receptor 10 polymorphisms with paediatric idiopathic uveitis in Han Chinese

“…Previous studies described PIU as the most predominant type, accounting for 57.8% to 74% of the PU population. [6][7][8][9] Many immune and inflammatory pathways play a role in the pathogenesis of uveitis. Unravelling these pathways may lead to the development of novel treatments and one of the approaches to identify the mechanisms involved in uveitis includes the analysis of immunogenetic predisposition to this disease.…”

Genetic aspects of idiopathic paediatric uveitis and juvenile idiopathic arthritis associated uveitis in Chinese Han

“…5 In PU, non-infectious uveitis and bilateral anterior uveitis is the major subtypes and similar frequencies have been reported from different geographical regions and ethnic backgrounds. [6][7][8][9] Only a few PU entities have been classified, including juvenile idiopathic arthritis (JIA), Behcet's disease (BD), Vogt-Koyanagi-Harada (VKH) disease and tubulointerstitial nephritis and uveitis syndrome. [9][10][11] In particular, JIA is the most common systemic disorder underlying PU, accounting for 4%-24% of total PU.…”

“…[6][7][8][9] Only a few PU entities have been classified, including juvenile idiopathic arthritis (JIA), Behcet's disease (BD), Vogt-Koyanagi-Harada (VKH) disease and tubulointerstitial nephritis and uveitis syndrome. [9][10][11] In particular, JIA is the most common systemic disorder underlying PU, accounting for 4%-24% of total PU. [12][13][14] PU, whereby a clear aetiology cannot be established, is classified as idiopathic paediatric uveitis (IPU) and the frequency of this entity is similar to juvenile idiopathic arthritis associated uveitis (JIA-U).…”

“…[12][13][14] PU, whereby a clear aetiology cannot be established, is classified as idiopathic paediatric uveitis (IPU) and the frequency of this entity is similar to juvenile idiopathic arthritis associated uveitis (JIA-U). [6][7][8][9] A genetic component is currently considered to play an important role in the pathogenesis of autoimmune disease. 15 16 Unravelling the genetic aspects of autoimmune disease may lead to the identification of the involved immune and inflammatory pathways and can result in novel treatment modalities.…”

Features of the course and treatment of JIA-associated uveitis

“…In 30% to 50% of children with JIA-associated uveitis structural complications are present at diagnosis. Of these, about 50% to 78% will eventually complications [8,9,18,19].…”