A 10-Year Survey: Prevalence of Ocular Surface Squamous Neoplasia in Clinically Benign Pterygium Specimens

Segev, Fani; Tessler, Gili; Hilely, Assaf; Ofir, Shay; Kidron, D.; Bahar, Irit

doi:10.3109/02713683.2014.993086

Cited by 16 publications

(12 citation statements)

References 30 publications

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“…Conjunctival SCC and pterygium may have a similar clinical presentation, but present different treatment requirements, therefore, differentiation is crucial. Some authors recently investigated the scope of the pathology screening of every excised pterygium [ 9 ] as well as the prevalence of invasive carcinomas in pterygium specimens [ 10 ], but found no justification for detailed pathology report in every case.…”

Section: Discussionmentioning

confidence: 99%

Ruthenium brachytherapy for intraocular growth of a conjunctival squamous cell carcinoma: a case report

Rospond-Kubiak¹,

Adamski²,

Sosnowska³

et al. 2018

jcb

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The aim of this study is to report the use of ruthenium brachytherapy as an adjunctive treatment in the management of an intraocular extension of the conjunctival squamous cell carcinoma (SCC).In 2013, a 73-year-old man presented with a tumor blocking the angle and infiltrating corneal endothelium. The patient was treated with iridectomy, and after one month, ruthenium brachytherapy was applied. 4.5 years post-irradiation, the treated eye is painless, and no recurrence was noted.We advocate the use of ruthenium brachytherapy as an eye salvage treatment with an intraocular extension of conjunctival SCC.

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Section: Discussionmentioning

confidence: 99%

Ruthenium brachytherapy for intraocular growth of a conjunctival squamous cell carcinoma: a case report

Rospond-Kubiak¹,

Adamski²,

Sosnowska³

et al. 2018

jcb

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“…Variants including mucoepidermoid, spindle cell, and OSSN associated with immunosuppression or HIV coinfection should be suspected in aggressive clinical presentations, massive tumors, and recurrent manifestations [33,36]. The difference in reported OSSN rates in clinically benign pterygium may be due to the wide variation in thresholds for grading squamous dysplasia between pathologists and institutions [20]. …”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, pterygium and OSSN can coexist, and several studies have implicated pterygium's origin as a stem cell disorder with premalignant features [19]. The rate of OSSN presence in excised pterygia specimens has been studied in several different countries with results ranging from 0 to 9.8% [20,21,22,23]. The presence of an unexpected OSSN with pterygium is a dilemma because of the vastly contrasting management procedures for pterygium and OSSN.…”

Section: Introductionmentioning

confidence: 99%

Conjunctival Squamous Cell Carcinoma with Corneal Stromal Invasion in Presumed Pterygia: A Case Series

Mendoza¹,

Craven

et al. 2018

Ocul Oncol Pathol

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Aim: To describe 4 cases of conjunctival squamous cell carcinoma (SCC) with corneal stromal invasion. Methods: Retrospective, clinicopathologic case series. Results: All patients had prior resections of presumed pterygia. The degree of corneal involvement dictated the extent of surgical management. One eye with localized invasion was treated with lamellar keratoplasty and plaque brachytherapy. Another case with widespread invasion warranted penetrating keratoplasty and eventual enucleation. Two cases were treated medically prior to surgical intervention: one with localized invasion was treated with topical interferon and retinoic acid; another with significant inflammation was treated with doxycycline and fluorometholone. The patient who underwent keratoplasty and brachytherapy had no recurrence after 7 years of follow-up. Those initially treated medically had resections of recurrence but ultimately required enucleation. Histologically, specimens demonstrated SCC invading the deep corneal stroma, with 2 tumors of the mucoepidermoid type. Conclusions: This series demonstrates the importance of maintaining clinical suspicion of conjunctival squamous neoplasia in pterygia. We recommend that all excised pterygia be submitted for histopathologic evaluation and be carefully evaluated for dysplasia and variants of SCC associated with increased risk of intraocular invasion. Undetected ocular surface squamous neoplasia may give rise to potentially vision- and eye-threatening invasive corneal SCC.

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“…Pterygium exhibits tumor-like features, including propensity to invade normal tissue, recurrence after excision and coexistence with premalignant lesions (4,7,8). Previous studies have demonstrated that pterygium epithelial cells (PECs) are highly proliferative, have features of epithelial-mesenchymal transition (EMT) and overexpress anti-apoptotic proteins (9)(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

A novel role for Livin in the response to ultraviolet�B radiation and pterygium development

Sheng

et al. 2020

Int J Mol Med

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A pterygium is an inflammatory, invasive and proliferative lesion on the ocular surface, which can decrease visual acuity, damage the ocular surface and affect the appearance of the eye. However, the underlying molecular mechanisms of the pathogenesis remain unclear. In the present study, the role of apoptosis-associated protein Livin in the occurrence and development of pterygium was investigated. Primary samples from quiescent or advanced clinical stages of pterygium and normal human conjunctival tissues were used to assess mRNA and protein expression levels of Livin using reverse transcription-quantitative PCR and immunohistochemistry, respectively. Livin was knocked down in pterygium epithelial cells (PECs) using small interfering RNA (siRNA), to investigate the role of Livin in PEC viability, migration, invasion ability and apoptosis. The cell viability, invasion ability and apoptosis of PECs following ultraviolet B (UVB) radiation alone or in combination with Livin silencing were also analyzed. Expression levels of Livin increased in the pterygium tissues compared with those in the normal conjunctiva at both the mRNA and protein levels. Livin expression levels in advanced pterygium were significantly higher compared with those in quiescent pterygium samples. Knockdown of Livin expression levels significantly reduced cell migration, invasion ability and cell viability, and induced apoptosis of PECs. Inhibition of Livin expression in PECs increased the expression levels of caspase-7, caspase-3 and E-cadherin, whereas expression levels of Snail were downregulated. Cell viability and invasion ability in PECs was enhanced following UVB radiation and Livin expression upregulated. UVB irradiation induced cell invasion ability of PECs and this was attenuated by Livin-silencing. Transfection with Livin siRNA also partially recovered the apoptosis rate of PECs, which was reduced by UVB irradiation. In conclusion, Livin was upregulated in pterygium, and UVB radiation functions in the development of pterygium by inducing Livin expression.

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A 10-Year Survey: Prevalence of Ocular Surface Squamous Neoplasia in Clinically Benign Pterygium Specimens

Abstract: Cases of clinically benign pterygium diagnosed and excised by an experienced corneal expert are less likely to harbor OSSN. The yield of routine histopathological examination of such specimens may be low.

Cited by 16 publications

References 30 publications

Ruthenium brachytherapy for intraocular growth of a conjunctival squamous cell carcinoma: a case report

Ruthenium brachytherapy for intraocular growth of a conjunctival squamous cell carcinoma: a case report

Conjunctival Squamous Cell Carcinoma with Corneal Stromal Invasion in Presumed Pterygia: A Case Series

A novel role for Livin in the response to ultraviolet�B radiation and pterygium development

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