A 12 month in vivo study on the response of bone to a hydroxyapatite–polymethylmethacrylate cranioplasty composite

Itokawa, Hiroshi; Hiraide, Tsuneo; Moriya, M.; Fujimoto, M.; Nagashima, Goro; Suzuki, Richard K.; Fujimoto, Tsukasa

doi:10.1016/j.biomaterials.2007.08.001

Cited by 68 publications

(50 citation statements)

References 22 publications

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“…After immersion into Ringer's solution, the tensile strength was not altered, whereas the fatigue properties were significantly reduced. The biocompatibility of PMMA/HA biocomposites was tested in vivo and enhanced osteogenic properties of the implants compared with single-phase PMMA were observed [436,[440][441][442][443]. It was shown that not only the mechanical properties of PMMA were improved but the osteoblast response of PMMA was also enhanced with the addition of HA [440].…”

Section: Calcium Orthophosphate Cement-based Biocomposites and Concretesmentioning

confidence: 99%

“…Various apatite-containing biocomposite formulations based on PMMA [435][436][437][438][439][440][441][442][443][444][445] and PEMA [94,446,447] have been already developed. Such biocomposites might be prepared by dispersion of apatite powder into a PMMA viscous fluid [448] and used for drug-delivery purposes [449].…”

Section: Calcium Orthophosphate Cement-based Biocomposites and Concretesmentioning

confidence: 99%

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Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

285

146

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Section: Calcium Orthophosphate Cement-based Biocomposites and Concretesmentioning

confidence: 99%

Section: Calcium Orthophosphate Cement-based Biocomposites and Concretesmentioning

confidence: 99%

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

285

146

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“…207 Addition of HA to PMMA also enhanced the biocompatibility and osteoconductivity of the cement. 208 Cements/composites containing β-TCP. Composite bone cements containing β-TCP were also reported to be biocompatible, and osteoconduction was attained within 4 weeks of direct contact with bone.…”

Section: Bone Cements/composites With Remineralizing Actionmentioning

confidence: 99%

Demineralization–remineralization dynamics in teeth and bone

Neel¹,

Aljabo²,

Strange³

et al. 2016

IJN

522

232

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Biomineralization is a dynamic, complex, lifelong process by which living organisms control precipitations of inorganic nanocrystals within organic matrices to form unique hybrid biological tissues, for example, enamel, dentin, cementum, and bone. Understanding the process of mineral deposition is important for the development of treatments for mineralization-related diseases and also for the innovation and development of scaffolds. This review provides a thorough overview of the up-to-date information on the theories describing the possible mechanisms and the factors implicated as agonists and antagonists of mineralization. Then, the role of calcium and phosphate ions in the maintenance of teeth and bone health is described. Throughout the life, teeth and bone are at risk of demineralization, with particular emphasis on teeth, due to their anatomical arrangement and location. Teeth are exposed to food, drink, and the microbiota of the mouth; therefore, they have developed a high resistance to localized demineralization that is unmatched by bone. The mechanisms by which demineralization–remineralization process occurs in both teeth and bone and the new therapies/technologies that reverse demineralization or boost remineralization are also scrupulously discussed. Technologies discussed include composites with nano- and micron-sized inorganic minerals that can mimic mechanical properties of the tooth and bone in addition to promoting more natural repair of surrounding tissues. Turning these new technologies to products and practices would improve health care worldwide.

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“…In composite materials, HA or tricalcium phosphate is combined with a variety of monomeric and polymeric materials such as silica, 8 alginate, 9 polycaprolactone, 10 poly(lactic-co-glycolic acid), 11 poly-L-lactide, 12 polymethylmethacrylate, 13 gelatin and silk fibroin, 14 poly(1,8-octanediol-co-citrate), 15 collagen, chitosan, or synthetic peptide with a β-sheet structure. 16 This combination of polymers and ceramics in the form of composite materials can overcome the drawbacks due to their inappropriate mechanical properties for load-bearing applications.…”

Section: Introductionmentioning

confidence: 99%

Support for the initial attachment, growth and differentiation of MG-63 cells: a comparison between nano-size hydroxyapatite and micro-size hydroxyapatite in composites

Filová¹,

Suchý²,

Sucharda³

et al. 2014

IJN

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Hydroxyapatite (HA) is considered to be a bioactive material that favorably influences the adhesion, growth, and osteogenic differentiation of osteoblasts. To optimize the cell response on the hydroxyapatite composite, it is desirable to assess the optimum concentration and also the optimum particle size. The aim of our study was to prepare composite materials made of polydimethylsiloxane, polyamide, and nano-sized (N) or micro-sized (M) HA, with an HA content of 0%, 2%, 5%, 10%, 15%, 20%, 25% (v/v) (referred to as N0–N25 or M0–M25), and to evaluate them in vitro in cultures with human osteoblast-like MG-63 cells. For clinical applications, fast osseointegration of the implant into the bone is essential. We observed the greatest initial cell adhesion on composites M10 and N5. Nano-sized HA supported cell growth, especially during the first 3 days of culture. On composites with micro-size HA (2%–15%), MG-63 cells reached the highest densities on day 7. Samples M20 and M25, however, were toxic for MG-63 cells, although these composites supported the production of osteocalcin in these cells. On N2, a higher concentration of osteopontin was found in MG-63 cells. For biomedical applications, the concentration range of 5%–15% (v/v) nano-size or micro-size HA seems to be optimum.

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A 12 month in vivo study on the response of bone to a hydroxyapatite–polymethylmethacrylate cranioplasty composite

Cited by 68 publications

References 22 publications

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Demineralization–remineralization dynamics in teeth and bone

Support for the initial attachment, growth and differentiation of MG-63 cells: a comparison between nano-size hydroxyapatite and micro-size hydroxyapatite in composites

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A 12 month in vivo study on the response of bone to a hydroxyapatite–polymethylmethacrylate cranioplasty composite

Cited by 68 publications

References 22 publications

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Demineralization&ndash;remineralization dynamics in teeth and bone

Support for the initial attachment, growth and differentiation of MG-63 cells: a comparison between nano-size hydroxyapatite and micro-size hydroxyapatite in composites

Contact Info

Product

Resources

About

Demineralization–remineralization dynamics in teeth and bone