A 12-Week Yoga-Based Lifestyle Intervention Might Positively Modify Cellular Aging in Indian Obese Individuals: A Randomized-Controlled Trial

Sharma, Piyush; Yadav, Raj Kumar; Khadgawat, Rajesh; Dada, Rima

doi:10.1089/jicm.2021.0215

Cited by 5 publications

(10 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The participant disposition was according to the CONSORT guidelines is shown in Figure 1 total of 123 people were screened for obesity between March 2017 and October 2019, 72 (males = 21, females = 51) of whom were included and randomized into SC ( n = 36) and YBLI ( n = 36). The demographic components like age, sex, education, physical activity, nutrient indices (total energy, carbohydrate, protein, fat etc), anthropometric parameters like height, weight, body mass index, waist circumference, hip circumference, waist hip ratio and other physiological parameters like systolic and diastolic blood pressure as well as pulse rate were comparable between the two intervention groups at the beginning of the study ( Table 1 ), also shown in our earlier publication associated with this study ( 29 ).…”

Section: Methodssupporting

confidence: 82%

“…Medical doctors constantly observed closely and interacted with the participants for the first two weeks at IHC. This allowed us to assess the effectiveness with good compliance, which was noted in our previous studies as well ( 21 – 24 , 26 , 27 , 29 , 45 ). Also, for better study compliance, we intentionally added one more time point at the 4 th week to evaluate the adherence of the participants to the recommended yoga program at their home based intervention.…”

Section: Methodsmentioning

confidence: 84%

“…We have demonstrated a significant reduction in stress, inflammation, and oxidative stress biomarkers in blood in obese individuals ( 24 , 45 ). Recently, we have also reported the positive impact of YBLI on markers of cellular aging (telomere length and telomerase level) in obese individuals ( 29 ).…”

Section: Introductionmentioning

confidence: 87%

“…Therefore, sample size was calculated using the data from the closest matching studies. Sample size calculation was done using the co-primary endpoints, i.e., telomere length and telomerase level as in our recently published article ( 29 ).…”

Section: Methodsmentioning

confidence: 99%

“…Individuals in the YBLI group directed a 12-week standardized, pretested yoga-based lifestyle intervention which is an integrated program consisting of theory and practice sessions ( 21 – 23 , 26 – 29 , 45 ). A typical day starts with a set of asanas (physical postures), pranayama (breathing exercises), dhyana (meditation) conducted by a trained yoga instructor for approximately 1 h to set a positive start of the day.…”

Section: Methodsmentioning

confidence: 99%

See 4 more Smart Citations

Transcriptional modulation of inflammation, and aging in Indian obese adults following a 12-week yoga-based lifestyle intervention: A randomized controlled trial

Sharma

Yadav²,

Khadgawat³

et al. 2022

Front. Med.

Self Cite

View full text Add to dashboard Cite

IntroductionObesity is one of the major global problems in today's world, both in children, and the adult age group. Current evidence suggests obesity alters the expression of various genes related to oxidative stress, inflammation, and aging. In recent times complementary therapy like yoga-based lifestyle intervention (YBLI) is used as an adjunct therapy to modern medicine. This study examines the efficacy of 12 weeks of yoga-based lifestyle intervention with standard care (SC) on the expression of genes related to oxidative stress, inflammation, and aging in obese adults.MethodsThis was a two-arm parallel randomized control trial implemented at Integral Health Clinic (IHC), an outpatient facility that regularly conducted YBLI programs for the prevention of lifestyle diseases like obesity and diabetes in the Department of Physiology, All India Institute of Medical Sciences (AIIMS), New Delhi. Blood samples at baseline and weeks 2,4, and 12 were collected from 72 adults (male n = 21; female n = 51) of age 20–45 years with a body–mass index (BMI) of 25–35 kg/m2 who were randomized to receive either a 12-week SC (n = 36) or YBLI (n = 36). SC included recommendations for the management of obesity as per Indian guidelines including a low-calorie individualized diet and physical activity. Asana (physical postures), pranayama (breathing exercises), and meditation were all part of the YBLI. Primary outcomes were relative fold change in the expression of genes associated with oxidative stress [Nuclear factor-kappa B (NF-Kappa B)], inflammation [Tumor necrosis factor-α (TNFα), interleukin-6 (IL-6)], and aging [human telomerase reverse transcriptase (TERT)] in peripheral blood mononuclear cells between the two groups at week-12.ResultsThere were no significant changes in fold change of TERT, IL-6, and NF-kappa B between the groups at week 12. The relative fold change of TERT was significantly greater in the YBLI group (p = <0.0001) vs the SC group at 2 weeks. The relative fold change of TNF α was significantly lower at week 12 in YBLI though the change was not continuous and reliable. Within both groups, TERT expression was significantly increased at week 2 though the change was greater in the YBLI group (p < 0.0001). TNF α gene expression was significantly lower at weeks 2 and 4, compared to baseline level, in the SC group but it increased at week 12.ConclusionThe results while did not confirm our hypothesis, are important to share with the scientific society, to be able to improve prospective study designs and find optimal time/intervention/biological marker settings for this highly important scientific field. The results are suggestive of a positive impact of YBLI and SC on the fold change of aging-related TERT gene in obesity, though the benefit was not evident till week 12. However, the results should be evaluated with caution and in light of other published studies. To better understand the positive effects of YBLI on oxidative stress, inflammation, and aging-related gene expression in obesity, larger studies are recommended.

show abstract

Section: Methodssupporting

confidence: 82%

Section: Methodsmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 87%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Transcriptional modulation of inflammation, and aging in Indian obese adults following a 12-week yoga-based lifestyle intervention: A randomized controlled trial

Sharma

Yadav²,

Khadgawat³

et al. 2022

Front. Med.

Self Cite

View full text Add to dashboard Cite

show abstract

What are we learning with Yoga: a text mining approach to literature

Raittz

Pierri

Perico

et al. 2022

Preprint

View full text Add to dashboard Cite

Techniques used in yoga existed long before science as we know it. However, with Yoga westernization, the proliferation of scientific studies addressing the subject is exponential. Even though the literature presents thousands of related articles, many studies are considered flimsy - the diversity of methods, areas of interest, and focus cause it to become a complex environment without general guidelines for the researcher. This status may represent one of the impediments to the field's evolution. This study aims to elaborate a global structure of the literature on Yoga to open the door for multidisciplinary collaboration and bring new light to some relevant aspects. Due to its complexity, we understand that techniques to model complex domains are necessary. Contemporary methods of Artificial Intelligence have promoted advances in Bioinformatics, including text mining to scientific literature. Through the vector representation of texts, we got semantic abilities and could organize data in a way that allowed us to acquire a global vision of this literature. Additionally, we made the platforms available to Yoga researchers to enable them to evaluate our findings and make their forays into the literature. Besides better understanding why we study Yoga, we discovered that the literature offers insights into the relationships in broader aspects.

show abstract

Psychoneuroimmunology of Meditation

Magan

Yadav

2022

Annals of Neurosciences

View full text Add to dashboard Cite

Background: Meditation is a conscious mental discipline, that has been implicated in the relaxation response. The mechanism behind such a relaxing effect is psychoneuroimmunology (PNI), based on the interaction between mind, physical health, and self-healing; that conceptualizes that stress and an individual’s emotional state led to predisposition to diseases. Research to date suggests that meditation may play an active role in remodeling the imbalance between mind and body by modulating the psychoneuroimmunological effects of stress. However, to date, the multi-dimensional psychoneuroimmune aspects of meditation together have not been completely explicated. An evidence-based mechanism has been framed for the first time in India to explain the psychoneuroimmunology of regular and long-term meditation practice. Summary: Present evidence-based mechanism confirms prefrontal cortex (PFC) acts as a ‘Functional Connectome’ where psycho-neuro-immune aspects of meditation function simultaneously to exert positive benefits in the regulation of cognitive and emotional behavior. Also, this mechanism will help us to understand how human augmentation with lifestyle modification fosters brain plasticity to overcome various neuropsychiatric illnesses. Key Message: Meditation is a scientific tool against neuro-psychiatric illnesses.

show abstract

A 12-Week Yoga-Based Lifestyle Intervention Might Positively Modify Cellular Aging in Indian Obese Individuals: A Randomized-Controlled Trial

Cited by 5 publications

References 53 publications

Transcriptional modulation of inflammation, and aging in Indian obese adults following a 12-week yoga-based lifestyle intervention: A randomized controlled trial

Transcriptional modulation of inflammation, and aging in Indian obese adults following a 12-week yoga-based lifestyle intervention: A randomized controlled trial

What are we learning with Yoga: a text mining approach to literature

Psychoneuroimmunology of Meditation

Contact Info

Product

Resources

About