A 14+7 day quarantine period and a dual nucleic acid testing reagent strategy detect potentially indiscoverable Coronavirus disease 2019 infections in Xiamen, China

Wang, Yongjing; Xue, Jian-Hang; Fang, Zan-Xi; Xie, Jia-Wen; Niu, Jianjun; Yang, Tian-Ci; Lin, Li‐Rong

doi:10.1016/j.cca.2022.06.006

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…As the number of quarantine days increased, the sensitivity of the RT-PCR was 71.43% up to day 7 and 85.71% up to day 14. The results were similar to Wang's studies [14], in which they used the same RT-PCR kits and found that the sensitivity of an RT-PCR for a person in quarantine for 7 d, 14 d, and 21 d was 72.25%, 84.59%, and 91.91%, respectively.…”

Section: Discussionsupporting

confidence: 87%

“…Different RT-PCR assays have been proposed, though the false-negative rate of RT-PCRs is high due to poor sample collection, inappropriate specimen type, low viral load, variability in viral shedding, and premature testing in the disease process [2]. The results of this study showed that in the first RT-PCR used to diagnose COVID-19 patients, specificity was 100% but sensitivity was 14.29%, and the false-negative rate was as high as 85.71%, similar to previous studies [9,14]. Our study also showed that the early use of nucleic acid testing alone (on the first day of quarantine) may lead to a missed diagnosis.…”

Section: Discussionsupporting

confidence: 83%

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Evaluating the Value of Anti-SARS-CoV-2 Antibody-Based Tests for COVID-19 Diagnosis

Xie

Wang

et al. 2022

JCM

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Background: The early detection of COVID-19 patients is fundamental for containing the pandemic. A reverse-transcriptase quantitative polymerase chain reaction (RT-PCR), which detects SARS-CoV-2 RNA, is the gold standard diagnostic test, although it can contribute to false-negative results. Consequently, supplementary diagnostic tests are urgently needed. Methods: To assess the value of anti-SARS-CoV-2 antibody-based tests for confirming COVID-19, a retrospective study was conducted on 3120 inbound overseas travelers who underwent a 14-day government quarantine in Xiamen from August 2020 to October 2020. The diagnostic accuracy of the total antibody that detected the anti-SARS-CoV-2 antibody and the RT-PCR that detected SARS-CoV-2 RNA was determined in comparison to the clinical diagnosis. Results: The COVID-19 positive rate was 3.14% (98/3120). The sensitivity and specificity of the RT-PCR test on the first day of quarantine were 14.29% and 100%, respectively, and the sensitivity and specificity of the total antibody were 93.88% and 99.40%, respectively. The kappa value between an RT-PCR on the first day of quarantine and a clinical diagnosis was 0.24 (95% CI, 0.14–0.35), indicating poor consistency. The kappa value between total antibodies and a clinical diagnosis was 0.88 (95% CI, 0.83–0.93), indicating perfect consistency. There were no differences in the positive rates of an RT-PCR in symptomatic COVID-19 (7.41% (2/27)) and asymptomatic COVID-19 (16.90 (12/71) (p = 0.338). Similarly, the positive rate of the total antibody tests showed no difference in symptomatic COVID-19 (96.30% (26/27)) and asymptomatic COVID-19 (92.96% (66/71)) (p = 0.676). Conclusion: SARS-CoV-2 antibodies are developed by the body in response to an infection or after vaccination; this can easily lead to a missed diagnosis. In the context of low sensitivity for an RT-PCR, SARS-CoV-2 antibody detection is an effective adjunct to RT-PCR detection, which can improve the diagnostic accuracy of COVID-19 and provide an effective complement to the false-negative results of an RT-PCR.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 83%

Evaluating the Value of Anti-SARS-CoV-2 Antibody-Based Tests for COVID-19 Diagnosis

Xie

Wang

et al. 2022

JCM

Self Cite

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“…After a large population of people is tested, the detected patients will be quarantined before they are cured [5]. The spread of the disease can be noticeably slowed down.…”

Section: Introductionmentioning

confidence: 99%

Fair Assignment for Reserved Nucleic Acid Testing

et al. 2022

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Corona Virus Disease 2019 (COVID-19) is now treating the health of millions of people worldwide. The Chinese government now applies nucleic acid testing as a tool to detect patients from healthy people to control the spread of COVID-19. However, people may come to the nucleic acid testing stations simultaneously, leading to long queues and wasting time. In this paper, we proposed the reserved nucleic acid testing method, which could be easily implemented via Web applications associated with nucleic acid testing. Its key idea is to assign people to different pre-scheduled time slots so that the number of people arriving at a certain time slot can be controlled under the capacity, and thus congestion can be relieved. The key question is how to assign people in a fair manner. We propose a concise model to formalize and analyze the minimum total envy and pairwise fairness assignment problem for a variety of reservation-based applications, including nuclear acid testing. Its objective is to maximize the sum of each person’s utility under the capacity constraints of time slots. The decision variables are the time slot assignment of each person. We show that the envy-freeness solution is usually unavailable. However, we can minimize the total envy through appropriate arrangements and realize pairwise fairness with equal-chance shuffling.

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Impact of different nucleic acid testing scenarios on COVID-19 transmission

Zhang,

Chen,

et al. 2024

Heliyon

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A 14+7 day quarantine period and a dual nucleic acid testing reagent strategy detect potentially indiscoverable Coronavirus disease 2019 infections in Xiamen, China

Cited by 4 publications

References 25 publications

Evaluating the Value of Anti-SARS-CoV-2 Antibody-Based Tests for COVID-19 Diagnosis

Evaluating the Value of Anti-SARS-CoV-2 Antibody-Based Tests for COVID-19 Diagnosis

Fair Assignment for Reserved Nucleic Acid Testing

Impact of different nucleic acid testing scenarios on COVID-19 transmission

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