A 16×20 electrochemical CMOS biosensor array with in-pixel averaging using polar modulation

Hsu, Chung-Lun; Sun, Alexander H.; Zhao, Yunting; Aronoff-Spencer, Eliah; Hall, Drew A.

doi:10.1109/cicc.2018.8357044

Cited by 19 publications

(10 citation statements)

References 6 publications

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“…Table 1 shows the performance comparison of the proposed system with the state-of-the-art work for bioimpedance measurements [2], [6], and [14]. It offers a complete system-on-chip utilizing SWS, MDM, and PDM.…”

Section: Measurement Resultsmentioning

confidence: 99%

An Impedance Measurement SoC with Highly Digital Magnitude and Phase-to-Digital Converter

Qaiser

Khan

Saadeh

2021

2021 IEEE International Symposium on Circuits and Systems (ISCAS)

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Electrical impedance spectroscopy (EIS) is a powerful technology for accurate disease detection at the pointof-care (POC) from biosensors. Nevertheless, EIS usually involves lock-in amplifiers and mixers to detect both the magnitude and phase of the complex impedances. This paper presents a highly digital impedance measurement system-onchip, which can convert the magnitude and phase of impedance to 10-bits digital codes integrated with a filter-based wide-range programmable sinusoidal wave synthesizer (SWS). The proposed SWS utilizes switched-capacitor circuits such that the corner frequency can be adjusted by changing its switching frequency. The proposed EIS system was fabricated using a 180nm process with an active area of only 0.35 mm 2 . The SWS generates output frequency in the range of 579 µHz-48.9 kHz with measured total harmonic distortion of 0.152% at 100 Hz and 0.116% at 10 kHz. The DNL of the proposed magnitude converter is within −0.34/+0.3 LSB and the INL is around −0.75/+2 LSB. To validate the function of the proposed EIS measurement system, it is utilized to detect the tumor necrosis factor α in biological samples.

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Section: Measurement Resultsmentioning

confidence: 99%

An Impedance Measurement SoC with Highly Digital Magnitude and Phase-to-Digital Converter

Qaiser

Khan

Saadeh

2021

2021 IEEE International Symposium on Circuits and Systems (ISCAS)

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“…In one research, Malpartida-Cardenas et al coupled 64 × 64 arrayed electrochemical ion-selective field-effect transistors (ISFETs) fabricated in unmodified CMOS technology with LAMP for Plasmodium falciparum malaria diagnosis and artemisinin-resistance detection [ 207 ]. Hsu et al have also reported an electrolyte–insulator–semiconductor (EIS) sensor array using a polar-mode measurement method for the detection of Zika Virus oligonucleotides [ 212 ]. Hence, CMOS has demonstrated great advantages for biosensing DNA and can be adopted for COVID-19 or the other pandemics.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Diagnostic Strategies. Part I: Nucleic Acid-Based Technologies

Shaffaf

Ghafar-Zadeh

2021

Bioengineering

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The novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused respiratory infection, resulting in more than two million deaths globally and hospitalizing thousands of people by March 2021. A considerable percentage of the SARS-CoV-2 positive patients are asymptomatic or pre-symptomatic carriers, facilitating the viral spread in the community by their social activities. Hence, it is critical to have access to commercialized diagnostic tests to detect the infection in the earliest stages, monitor the disease, and follow up the patients. Various technologies have been proposed to develop more promising assays and move toward the mass production of fast, reliable, cost-effective, and portable PoC diagnostic tests for COVID-19 detection. Not only COVID-19 but also many other pathogens will be able to spread and attach to human bodies in the future. These technologies enable the fast identification of high-risk individuals during future hazards to support the public in such outbreaks. This paper provides a comprehensive review of current technologies, the progress in the development of molecular diagnostic tests, and the potential strategies to facilitate innovative developments in unprecedented pandemics.

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“…The operation principle of this structure is based on assessing the alterations resulted from DNA hybridization on the sensor's surface employing a trans-impedance enhancer, a detector, and a primary converter. This EIS-based biosensing system holds the potential for accurate and reliable biosensing in POC applications [47]. In another work (See Fig.…”

Section: Different Types Of Biosensors a Electrochemicalmentioning

confidence: 92%

Portable Sensing Devices for Detection of COVID-19: A Review

Sadighbayan

Ghafar-Zadeh

2021

IEEE Sensors J.

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The coronavirus pandemic is the most challenging incident that people have faced in recent years. Despite the time-consuming and expensive conventional methods, point-of-care diagnostics have a crucial role in deterrence, timely detection, and intensive care of the disease's progress. Hence, this detrimental health emergency persuaded researchers to accelerate the development of highly-scalable diagnostic devices to control the propagation of the virus even in the least developed countries. The strategies exploited for detecting COVID-19 stem from the already designed systems for studying other maladies, particularly viral infections. The present report reviews not only the novel advances in portable diagnostic devices for recognizing COVID-19, but also the previously existing biosensors for detecting other viruses. It discusses their adaptability for identifying surface proteins, whole viruses, viral genomes, host antibodies, and other biomarkers in biological samples. The prominence of different types of biosensors such as electrochemical, optical, and electrical for detecting low viral loads have been underlined. Thus, it is anticipated that this review will assist scientists who have embarked on a competition to come up with more efficient and marketable in-situ test kits for identifying the infection even in its incubation time without sample pretreatment. Finally, a conclusion is provided to highlight the importance of such an approach for monitoring people to combat the spread of such contagious diseases.

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A 16×20 electrochemical CMOS biosensor array with in-pixel averaging using polar modulation

Cited by 19 publications

References 6 publications

An Impedance Measurement SoC with Highly Digital Magnitude and Phase-to-Digital Converter

An Impedance Measurement SoC with Highly Digital Magnitude and Phase-to-Digital Converter

COVID-19 Diagnostic Strategies. Part I: Nucleic Acid-Based Technologies

Portable Sensing Devices for Detection of COVID-19: A Review

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