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Over the past two decades, nanopores have been a promising technology for next generation deoxyribonucleic acid (DNA) sequencing. Here, we present a hybrid semi-digital transimpedance amplifier (HSD-TIA) to sense the minute current signatures introduced by single-stranded DNA (ssDNA) translocating through a nanopore, while discharging the baseline current using a semi-digital feedback loop. The amplifier achieves fast settling by adaptively tuning a DC compensation current when a step input is detected. A noise cancellation technique reduces the total input-referred current noise caused by the parasitic input capacitance. Measurement results show the performance of the amplifier with 31.6 M Ω mid-band gain, 950 kHz bandwidth, and 8.5 fA/ √Hz input-referred current noise, a 2× noise reduction due to the noise cancellation technique. The settling response is demonstrated by observing the insertion of a protein nanopore in a lipid bilayer. Using the nanopore, the HSD-TIA was able to measure ssDNA translocation events.

This paper proposes a third-order low-distortion deltasigma modulator (DSM). The third-order noise shaping is achieved by a single opamp (excluding the quantizer). In the proposed DSM structure, the timing limitation on the quantizer and dynamic element matching (DEM) logic in a conventional low-distortion structure can be relaxed from a nonoverlapping interval to half of the clock period. A cyclic analog-to-digital converter with a loading-free technique is utilized as a quantizer, which shares an opamp with the active adder. The signal transfer function (STF) is preserved as unity, which means that the integrators process only the quantization noise component. As a result, the opamp used for the integrators has lower requirements, as low-distortion DSMs, on slew rate, output swing, and power consumption. The proposed third-order DSM with a 4bit cyclic-type quantizer is implemented in a 90-nm CMOS process. Under a sampling rate of 80 MHz and oversampling ratio of 16, simulation results show that an 81.97-dB signal-to-noise and distortion ratio and an 80-dB dynamic range are achieved with 4.17-mW total power consumption. The resulting figure of merit (FOM) is 81.5 fJ/conversion-step.

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