A 23‐year‐old woman with fever, rash, and arthritis

Abstract

A 23-year-old Hispanic woman presented with a 1-month history of rash, arthritis, and fever. The patient was in excellent health until 1 month prior to presentation, when she noted the spontaneous onset of a pruritic rash that began on her face and then progressed to involve her trunk and extremities. Shortly afterward, she developed pain and swelling of both hands, particularly of her wrists and metacarpophalangeal (MCP) joints. One week prior to presentation, she noted a sore throat and diffuse body aches together with subjective fevers and chills. She denied drenching sweats during febrile episodes. On evaluation in an emergency department, she was afebrile and had a diffuse erythematous rash that spared her palms and soles and mucous membranes. Laboratory evaluation showed a normal complete blood cell count, normal chemistries, including liver tests, and a normal urinalysis. The erythrocyte sedimentation rate (ESR) was 35 mm/hour (normal value Յ20) and the C-reactive protein (CRP) level was 53 mg/liter (normal value Ͻ3

Updates in adult-onset Still disease: Atypical cutaneous manifestations and associations with delayed malignancy

“…Predictably, AOSD-like symptoms were most strongly linked to lymphoma, 26,28,31,38,40,41,43,44 and both B-and T-cell lymphomas have been reported (8/31; 26%). Lymphadenopathy may occur in either AOSD or AOSD-like symptoms, but microscopic examination of lymph nodes reveals reactive hyperplasia in this context.…”

“…Management of the symptoms of AOSD symptoms in the setting of malignancy required high-dose systemic glucocorticoids in 26 cases [23][24][25][26][27][28][29][30][31][32][33][34][35][38][39][40][41][42][43][44][45]47,[50][51][52] and additional systemic therapies in 6 cases, including cyclosporine, 23,35,41 methotrexate, 24,31 cyclophosphamide, 31,35 and azathioprine. 32 Importantly, multiple reports have reflected the relapse of symptoms while weaning off antiinflammatory therapy in the absence of definitive treatment of the primary malignancy.…”

Immunomodulatory effects of some Namibian plants traditionally used for treating inflammatory diseases

“…However, medicinal plants are used anecdotally and based on past experiences, hence they lack scientific validation (Ozioma and Chinwe, 2019). This validation of the traditional herbal treatments will allow their safe, cheap and effective use and provide a basis for their integration into mainstream healthcare Traditionally, Acanthosicyos naudinianus, Gomphocarpus fruticosus and Cryptolepis decidua are used to treat conditions such as pain, fever and skin rashes, which are symptoms of inflammatory responses (Gratton and Imboden, 2010;Sonoda et al, 2017), a criteria for selecting the plants under investigation. A few studies relating to the biological activities have been done, including anticancer: A. naudinianus, antibacterial (Saidu et al, 2014), anti-inflammatory, antioxidant, anticancer and anti-viral (HPV-1) (Twilley et al, 2017): G. fruticosus.…”