A 24-Ch. Multi-Electrode Array Allowing Fast EIS to Determine Transepithelial Electrical Resistance

Abstract

Electrochemical Impedance Spectroscopy (EIS) is a standard method to investigate properties of biological samples due to its non-invasiveness. Multi-electrode arrays (MEA) perform parallel measurements, which lead to higher throughput and thus reduced measurement time. However, implementing a parallel MEA EIS needs considerations to achieve safe and fast measurements. Commercially available devices perform single EIS and then serially scan the MEA. Their limited frequency range and limited detection impedance can be further increased to support more application. This work presents a 24 channel MEA EIS system that has highly reduced measurement time in comparison to commercially available solutions by utilizing multitone excitation signals. The EIS system has been implemented on a two layer PCB and successfully tested with biological samples. It consumes 17.5 × 17.5 cm 2 and draws 300 mA from a 5 V supply voltage. The EIS measurement frequency range spans from 10 mHz to 100 kHz and can detect impedances from 6 Ω to 300 kΩ. The prototype measurements have been compared with the commercially available devices and showed matching better than 95%.

Development of a Novel Medical Device for Mucositis and Peri-Implantitis Treatment

“…It is easy to understand that the subjectivity and the experience of the clinician play pivotal roles in the outcome of the diagnostic procedure, furnishing results hardly comparable due to their variability. However, in the literature, there is evidence of a relationship between bioimpedance and tissue characteristics, including their electrical properties and their physiological/pathological status; the interest in bioimpedance measurement is growing, proven by the increasing literature on this topic [ 34 , 35 ]. In particular, the composition of the tissue can be characterized if the measurement is performed in a very localized and precise way [ 36 ], allowing valuable applications of body impedance analysis (BIA) [ 37 , 38 ].…”