Modeling large spatial deflections of flexible beams has been one of the most challenging problems in the research community of compliant mechanisms. This work presents a method called chained spatial-beam constraint model (CSBCM) for modeling large spatial deflections of flexible bisymmetric beams in compliant mechanisms. CSBCM is based on the spatial-beam constraint model (SBCM), which was developed for the purpose of accurately predicting the nonlinear constraint characteristics of bisymmetric spatial beams in their intermediate deflection range. CSBCM deals with large spatial deflections by dividing a spatial beam into several elements, modeling each element with SBCM, and then assembling the deflected elements using the transformation defined by Tait–Bryan angles to form the whole deflection. It is demonstrated that CSBCM is capable of solving various large spatial deflection problems either the tip loads are known or the tip deflections are known. The examples show that CSBCM can accurately predict large spatial deflections of flexible beams, as compared to the available nonlinear finite element analysis (FEA) results obtained by ansys. The results also demonstrated the unique capabilities of CSBCM to solve large spatial deflection problems that are outside the range of ansys.