2014
DOI: 10.1016/j.fct.2014.10.025
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A 3-week pre-clinical study of 2′-fucosyllactose in farm piglets

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Cited by 17 publications
(10 citation statements)
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“…The nutritional intervention with 2′-FL did not show biologically relevant changes in the growth of the animals compared to the REF group, as similarly evidenced in other studies (18, 19, 26, 38). In addition, the relative weights of the organs analyzed and the stool characteristics were not affected after 15 days of supplementation, confirming that their administration was safe and well-tolerated, which is in line with studies performed by other authors (26, 39). The histomorphometric analysis of the small intestine revealed that administration of 2′-FL for 7 days had an intestinal trophic effect as observed by higher villus heights and areas.…”
Section: Discussionsupporting
confidence: 89%
“…The nutritional intervention with 2′-FL did not show biologically relevant changes in the growth of the animals compared to the REF group, as similarly evidenced in other studies (18, 19, 26, 38). In addition, the relative weights of the organs analyzed and the stool characteristics were not affected after 15 days of supplementation, confirming that their administration was safe and well-tolerated, which is in line with studies performed by other authors (26, 39). The histomorphometric analysis of the small intestine revealed that administration of 2′-FL for 7 days had an intestinal trophic effect as observed by higher villus heights and areas.…”
Section: Discussionsupporting
confidence: 89%
“…The doses of 6 -SL utilized in the study were comparable to those found in human milk, and reflected concentrations found in the colostrum (range 250-1300 mg/L; MOD and HIGH) and mature milk (range 170-500 mg/L; LOW) [5,9]. In addition, none of the 6 -SL doses tested had produced adverse effects on hematological, chemical, and histological parameters and were comparable to sow-reared and artificially-reared piglets at similar ages [17,21].…”
Section: Discussionsupporting
confidence: 70%
“…The results indicated inflammatory processes in a few organs in both groups, leading to the conclusion that those findings were independent of 6 -SL supplementation. Others have reported that incidental microscopic findings are occasionally seen in piglets of similar age to those used in our study [21,31]. Another minor finding was the presence of blood cells in urine, which was independent on 6-SL supplementation.…”
Section: Discussionsupporting
confidence: 67%
“…This exemplifies the necessity of identifying an appropriate challenge model to assess the effects of dietary compounds on the immune system. In mice, the milk oligosaccharides LNFP III and LNnT are Th2-biasing and suppress Th1 responses [55]. Recently, it has been reported that human infants who were fed human milk with low LNFP III concentrations (<60 μM) were 6.7-times (95% CI 2.0–22) more likely to become affected with cow’s milk allergy when compared to infants receiving milk with high LNFP III concentrations [56].…”
Section: Hmo As Modulators Of Systemic Immunity and Protection From Imentioning
confidence: 99%