Herein, the analog-based, 2-tap feed-forward equalization (FFE) voltage-mode transmitter using dual supply/ground voltage regulation is presented. In an FFE data modulator, the data are divided into transition and non-transition segments, and are transmitted to the main-and post-tap drivers. By using dual voltage regulation, flexible FFE strength adjustment is possible without process dependency, and the shortcurrent path is eliminated, thus improving the overall energy efficiency. Furthermore, this structure with independent impedance calibration loops has good on-resistance and return loss characteristics, thereby securing signal integrity. In addition, by regulating the supply/ground voltages, the output swing and common-mode voltage can be adjusted independently. Therefore, our transmitter can serve multiple standards and channel environments with a single design. To verify the effectiveness of our method, we designed a prototype of the source-synchronous transmitter in a 65 nm CMOS process, and its performance was compared with that of a conventional FFE design. The simulation results show that the proposed design has better on-resistance, return loss, and FFE controllability, and it has an energy efficiency of 2.23 pJ/bit at 20 Gb/s.