A 3D Bioprinted Pseudo-Bone Drug Delivery Scaffold for Bone Tissue Engineering

Kondiah, Pariksha J.; Kondiah, Pierre P.D.; Choonara, Yahya E.; Marimuthu, Thashree; Pillay, Viness

doi:10.3390/pharmaceutics12020166

Cited by 65 publications

(34 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The matrix analysis showed that after the application of the scaffolds, the fractured bone had similar matrix hardness and matrix resilience to healthy human clavicle bones. This highlights the potential for bioprinted pseudo bone scaffolds to fill in fracture sites, resulting in great adhesion of the fractured bone and restoration to intended mechanical strength [11].…”

Section: Three-dimensional Bioprintingmentioning

confidence: 99%

3D Printing of Pharmaceuticals and Drug Delivery Devices

et al. 2020

View full text Add to dashboard Cite

The process of 3D printing (3DP) was patented in 1986; however, the research in the field of 3DP did not become popular until the last decade. There has been an increasing research into the areas of 3DP for medical applications for fabricating prosthetics, bioprinting and pharmaceutics. This novel method allows the manufacture of dosage forms on demand, with modifications in the geometry and size resulting in changes to the release and dosage behaviour of the product. 3DP will allow wider adoption of personalised medicine due to the diversity and simplicity to change the design and dosage of the products, allowing the devices to be designed specific to the individual with the ability to alternate the drugs added to the product. Personalisation also has the potential to decrease the common side effects associated with generic dosage forms. This Special Issue Editorial outlines the current innovative research surrounding the topic of 3DP, focusing on bioprinting and various types of 3DP on applications for drug delivery as well advantages and future directions in this field of research.

show abstract

Section: Three-dimensional Bioprintingmentioning

confidence: 99%

3D Printing of Pharmaceuticals and Drug Delivery Devices

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Recently, a 3D bioprinted pseudo-bone drug delivery scaffold for simvastatin was generated to promote bone healing. This scaffold displayed matrix strength, matrix resilience, and porous morphology of healthy human bone [ 203 ].…”

Section: Bioprinting Processmentioning

confidence: 99%

Advances on Bone Substitutes through 3D Bioprinting

Genova

Roato

Carossa

et al. 2020

IJMS

110

View full text Add to dashboard Cite

Reconstruction of bony defects is challenging when conventional grafting methods are used because of their intrinsic limitations (biological cost and/or biological properties). Bone regeneration techniques are rapidly evolving since the introduction of three-dimensional (3D) bioprinting. Bone tissue engineering is a branch of regenerative medicine that aims to find new solutions to treat bone defects, which can be repaired by 3D printed living tissues. Its aim is to overcome the limitations of conventional treatment options by improving osteoinduction and osteoconduction. Several techniques of bone bioprinting have been developed: inkjet, extrusion, and light-based 3D printers are nowadays available. Bioinks, i.e., the printing materials, also presented an evolution over the years. It seems that these new technologies might be extremely promising for bone regeneration. The purpose of the present review is to give a comprehensive summary of the past, the present, and future developments of bone bioprinting and bioinks, focusing the attention on crucial aspects of bone bioprinting such as selecting cell sources and attaining a viable vascularization within the newly printed bone. The main bioprinters currently available on the market and their characteristics have been taken into consideration, as well.

show abstract

“… ( i ) Schematic diagram of stereolithography (SLA) printer setup [ 63 ]. ( ii ) ( A ) Proposed 3D model, ( B ) macroscopic view of SLA-printed scaffolds containing PTMC only and PTMC with two varying ratios of HA respectively and ( C ) representative SEM images of the SLA-printed scaffolds [ 64 ]. ( iii ) A rapid prototype generation starting from MR images, the triangulated mesh is generated.…”

Section: Figurementioning

confidence: 99%

3D Printing for Hip Implant Applications: A Review

et al. 2020

View full text Add to dashboard Cite

There is a rising demand for replacement, regeneration of tissues and organ repairs for patients who suffer from diseased/damaged bones or tissues such as hip pains. The hip replacement treatment relies on the implant, which may not always meet the requirements due to mechanical and biocompatibility issues which in turn may aggravate the pain. To surpass these limitations, researchers are investigating the use of scaffolds as another approach for implants. Three-dimensional (3D) printing offers significant potential as an efficient fabrication technique on personalized organs as it is capable of biomimicking the intricate designs found in nature. In this review, the determining factors for hip replacement and the different fabrication techniques such as direct 3D printing, Fused Deposition Modelling (FDM), Selective Laser Sintering (SLS) and stereolithography (SLA) for hip replacement. The study also covers surface modifications of 3D printed implants and provides an overview on 3D tissue regeneration. To appreciate the current conventional hip replacement practices, the conventional metallic and ceramic materials are covered, highlighting their rationale as the material of choice. Next, the challenges, ethics and trends in the implants’ 3D printing are covered and conclusions drawn. The outlook and challenges are also presented here. The knowledge from this review indicates that 3D printing has enormous potential for providing a pathway for a sustainable hip replacement.

show abstract

A 3D Bioprinted Pseudo-Bone Drug Delivery Scaffold for Bone Tissue Engineering

Cited by 65 publications

References 31 publications

3D Printing of Pharmaceuticals and Drug Delivery Devices

3D Printing of Pharmaceuticals and Drug Delivery Devices

Advances on Bone Substitutes through 3D Bioprinting

3D Printing for Hip Implant Applications: A Review

Contact Info

Product

Resources

About