A 3D LTCC-Based Ceramic Microfluidic System with RF Dielectric Heating of Liquids

Makarovič, Kostja; Belavič, Darko; Vidmar, M.; Malič, Barbara

doi:10.3390/ma14237396

Cited by 3 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In multilayer ceramic, buried channels, conductive lines, and vias are added to perform various functions, from fluid mixing to passive and active thermal transfer [1][2][3][4][5][6][7][8][9]. Low-temperature cofired ceramics (LTCCs), and to a lesser degree high-temperature cofired ceramics (HTCCs), have been recognized as suitable materials for the fabrication of such structures [2][3][4][5][6][7][8][9][10]. LTCCs are most commonly glass-ceramic composite materials, while HTCCs are generally alumina with sintering aids [11].…”

Section: Introductionmentioning

confidence: 99%

Metallization, Material Selection, and Bonding of Interconnections for Novel LTCC and HTCC Power Modules

Sešek

Makarovič

2022

Materials

Self Cite

View full text Add to dashboard Cite

Ceramic baseplates are important elements in the power modules of electric drives. This paper presents low-temperature cofired ceramic (LTCC) and high-temperature cofired ceramic (HTCC) materials for the fabrication of three-dimensional power modules. The silver-based metallization and power module assembly are presented, together with aluminum-based power wire bonding and an industrial procedure to achieve high solderability and bondability. The results of the bond tests using different metallization materials, especially cost-effective ones, are presented, together with the assembly of the power modules. The best results were achieved with Ag metallization and 380 µm Al wire and with Ag–Pd metallization and 25 µm Al wire, both on an LTCC base. The paper concludes with a dual-pulse electrical test of the power modules, which proves the quality of metallization, the type of material selected, and the correctness of the wire bonding and assembly.

show abstract

Section: Introductionmentioning

confidence: 99%

Metallization, Material Selection, and Bonding of Interconnections for Novel LTCC and HTCC Power Modules

Sešek

Makarovič

2022

Materials

Self Cite

View full text Add to dashboard Cite

show abstract

3D bio-printed hydrogel inks promoting lung cancer cell growth in a lab-on-chip culturing platform

Krakos,

Cieślak,

Hartel

et al. 2023

Microchim Acta

View full text Add to dashboard Cite

The results of a lab-on-chip (LOC) platform fabrication equipped with a hydrogel matrix is reported. A 3D printing technique was used to provide a hybrid, “sandwiched” type structure, including two microfluidic substrates of different origins. Special attention was paid to achieving uniformly bio-printed microfluidic hydrogel layers of a unique composition. Six different hydrogel inks were proposed containing sodium alginate, agar, chitosan, gelatin, methylcellulose, deionized water, or 0.9% NaCl, varying in proportions. All of them exhibited appropriate mechanical properties showing, e.g., the value of elasticity modulus as similar to that of biological tissues, such as skin. Utilizing our biocompatible, entirely 3D bio-printed structure, for the first time, a multi-drug-resistant lung cancer cell line (H69AR) was cultured on-chip. Biological validation of the device was performed qualitatively and quantitatively utilizing LIVE/DEAD assays and Presto blue staining. Although all bio-inks exhibited acceptable cell viability, the best results were obtained for the hydrogel composition including 3% sodium alginate + 7% gelatin + 90% NaCl (0.9%), reaching approximately 127.2% after 24 h and 105.4% after 48 h compared to the control group (100%). Further research in this area will focus on the microfluidic culture of the chosen cancer cell line (H69AR) and the development of novel drug delivery strategies towards appropriate in vivo models for chemotherapy and polychemotherapy treatment. Graphical abstract

show abstract

Lab-on-chip technologies for space research — current trends and prospects

Krakos

2023

Microchim Acta

View full text Add to dashboard Cite

The in-depth analysis concerning application of microfluidic instruments for space biology research is presented. The article focuses on recently investigated key scientific fields, i.e., lab-on-chips applied to the biomedical studies performed in the (1) International Space Station and (2) CubeSat nanosatellites. The paper presents also the lab-on-chip devices that were fabricated with a view to future space biology research and to those that to date have been solely been tested under Earth laboratory conditions and/or simulated microgravity environments. NASA and ESA conceptual mission plans for future are also mentioned, concerning for instance “tissue chips” and the ESA-SPHEROIDS campaign. The paper ends with final conclusions and future perspectives regarding lab-on-chip application in the space biology sector and its impact on novel biomedical and pharmaceutical strategies. Graphical Abstract

show abstract

A 3D LTCC-Based Ceramic Microfluidic System with RF Dielectric Heating of Liquids

Cited by 3 publications

References 15 publications

Metallization, Material Selection, and Bonding of Interconnections for Novel LTCC and HTCC Power Modules

Metallization, Material Selection, and Bonding of Interconnections for Novel LTCC and HTCC Power Modules

3D bio-printed hydrogel inks promoting lung cancer cell growth in a lab-on-chip culturing platform

Lab-on-chip technologies for space research — current trends and prospects

Contact Info

Product

Resources

About