A 3D porous microsphere with multistage structure and component based on bacterial cellulose and collagen for bone tissue engineering

Wen, Zheng; Wang, Xuechuan; Li, Xi-yue; Zhang, Lele; Jiang, Fei

doi:10.1016/j.carbpol.2020.116043

Cited by 92 publications

(36 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the limitations of a single material in biological, physical, and chemical properties, composite biomaterials have combined advantages on improving biological characteristics and multiple performances for bone regeneration. Composite materials are mainly divided into composite of various materials (such as composite between bioceramics and polymer materials), composite of preparation technology and materials, and composite of tissue engineering technology and materials (Chen et al, 2019;Zhang et al, 2020). We use collagen as an example to demonstrate the importance of composite materials on bone regeneration.…”

Section: Composite Materialsmentioning

confidence: 99%

Recent Trends in the Development of Bone Regenerative Biomaterials

Tang

Liu

et al. 2021

Front. Cell Dev. Biol.

130

View full text Add to dashboard Cite

The goal of a biomaterial is to support the bone tissue regeneration process at the defect site and eventually degrade in situ and get replaced with the newly generated bone tissue. Biomaterials that enhance bone regeneration have a wealth of potential clinical applications from the treatment of non-union fractures to spinal fusion. The use of bone regenerative biomaterials from bioceramics and polymeric components to support bone cell and tissue growth is a longstanding area of interest. Recently, various forms of bone repair materials such as hydrogel, nanofiber scaffolds, and 3D printing composite scaffolds are emerging. Current challenges include the engineering of biomaterials that can match both the mechanical and biological context of bone tissue matrix and support the vascularization of large tissue constructs. Biomaterials with new levels of biofunctionality that attempt to recreate nanoscale topographical, biofactor, and gene delivery cues from the extracellular environment are emerging as interesting candidate bone regenerative biomaterials. This review has been sculptured around a case-by-case basis of current research that is being undertaken in the field of bone regeneration engineering. We will highlight the current progress in the development of physicochemical properties and applications of bone defect repair materials and their perspectives in bone regeneration.

show abstract

Section: Composite Materialsmentioning

confidence: 99%

Recent Trends in the Development of Bone Regenerative Biomaterials

Tang

Liu

et al. 2021

Front. Cell Dev. Biol.

130

View full text Add to dashboard Cite

show abstract

“…An in vivo study demonstrated the subcutaneous implantation of BNC in rats up to 12 weeks that did not show any signs of immunogenicity, inflammation, or formation of exudates around the implant (Helenius et al, 2006). Although non-toxic, pristine BNC lacks cell adhesion sites and its biocompatibility is not up to the desired levels in some cases; thus, different strategies like a surface modification to introduce bioactive functional groups such as peptides antimicrobial peptides (Fürsatz et al, 2018) and formation of composites with compatible polymers like gelatin (Khan et al, 2018), chitosan (Ul- Islam et al, 2019b), collagen (Zhang et al, 2020;Li et al, 2021), and other materials, have been developed to achieve the desired biocompatibility for specific applications (Phanthong et al, 2018;Ullah et al, 2019b; Table 1).…”

Section: Biocompatibilitymentioning

confidence: 99%

Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases

Khan

Siddique

Huanfei

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Bone serves to maintain the shape of the human body due to its hard and solid nature. A loss or weakening of bone tissues, such as in case of traumatic injury, diseases (e.g., osteosarcoma), or old age, adversely affects the individual’s quality of life. Although bone has the innate ability to remodel and regenerate in case of small damage or a crack, a loss of a large volume of bone in case of a traumatic injury requires the restoration of bone function by adopting different biophysical approaches and chemotherapies as well as a surgical reconstruction. Compared to the biophysical and chemotherapeutic approaches, which may cause complications and bear side effects, the surgical reconstruction involves the implantation of external materials such as ceramics, metals, and different other materials as bone substitutes. Compared to the synthetic substitutes, the use of biomaterials could be an ideal choice for bone regeneration owing to their renewability, non-toxicity, and non-immunogenicity. Among the different types of biomaterials, nanocellulose-based materials are receiving tremendous attention in the medical field during recent years, which are used for scaffolding as well as regeneration. Nanocellulose not only serves as the matrix for the deposition of bioceramics, metallic nanoparticles, polymers, and different other materials to develop bone substitutes but also serves as the drug carrier for treating osteosarcomas. This review describes the natural sources and production of nanocellulose and discusses its important properties to justify its suitability in developing scaffolds for bone and cartilage regeneration and serve as the matrix for reinforcement of different materials and as a drug carrier for treating osteosarcomas. It discusses the potential health risks, immunogenicity, and biodegradation of nanocellulose in the human body.

show abstract

“…A promising approach is based on the possibility of obtaining structures similar to biological membranes, organs, and tissues [70] with the goal of using them as implants or in tissue engineering [71][72][73]. The method and the carrier are selected on the basis of the stability of biomaterial and its activity, including diffusion properties of the carrier.…”

Section: Encapsulation Of Cells and Microorganismsmentioning

confidence: 99%

Methods of Encapsulation of Biomacromolecules and Living Cells. Prospects of Using Metal–Organic Frameworks

et al. 2021

View full text Add to dashboard Cite

The review discusses different methods of encapsulation and biomineralization of macromolecules and living cells. Main advantages and disadvantages of most commonly used carriers, matrices, and materials for immobilization of proteins, enzymes, nucleic acids, and living cells are briefly surveyed. Examples of delivery vehicles for multifunctional encapsulation of protein-like substances are presented. Particular attention is paid to prospects of using metal-organic frameworks in medicine and biotechnology.

show abstract

A 3D porous microsphere with multistage structure and component based on bacterial cellulose and collagen for bone tissue engineering

Cited by 92 publications

References 39 publications

Recent Trends in the Development of Bone Regenerative Biomaterials

Recent Trends in the Development of Bone Regenerative Biomaterials

Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases

Methods of Encapsulation of Biomacromolecules and Living Cells. Prospects of Using Metal–Organic Frameworks

Contact Info

Product

Resources

About