A 3D printed melt-compounded antibiotic loaded thermoplastic polyurethane heart valve ring design: an integrated framework of experimental material tests and numerical simulations

Gasparotti, Emanuele; Vignali, Emanuele; Losi, Paola; Scatto, Marco; Fanni, Benigno Marco; Soldani, Giorgio; Landini, Luigi; Positano, Vincenzo; Celi, Simona

doi:10.1080/00914037.2018.1525717

Cited by 31 publications

(27 citation statements)

References 23 publications

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“…Recently, SPU have been explored for FDM processing for biomedical applications. However, most of them were biostable SPU intended for medical devices, 39‐41 and only a few focused in tissue engineering applications 17,20,42‐45 . Among the latter, a segmented poly(ester urethane) (SPEU) with high HS content (77% wt/wt), obtained from the reaction of poly(ε‐caprolactone‐co‐ d,l ‐lactide) diol with a uniform 5‐block chain extender synthesized from butane diisocyanate (BDI) and butanediol (BDO), was filament‐free processed into porous scaffolds with mechanical properties matching those of articular cartilage 42 …”

Section: Introductionmentioning

confidence: 99%

Novel three‐dimensional printing of poly(ester urethane) scaffolds for biomedical applications

Lores

Hung

Talou

et al. 2021

Polymers for Advanced Techs

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Tissue engineering requires highly porous complex structures with interconnected pores and tightly controlled pore sizes, added to customized production. Additive manufacturing (AM) is nowadays one of the most suitable technologies for the preparation of structures with strictly defined complex three‐dimensional architectures. Moreover, computed tomography and magnetic resonance imaging can be employed to obtain personalized medical devices. Fused deposition modeling (FDM) is one of the most common, easiest, and cost‐effective AM techniques to obtain 3D objects from a wide variety of materials. However, there is a lack of bioresorbable materials that can fit the increasing demand for biomedical applications requiring stiff elastomers. In this work, a series of bioresorbable segmented poly(ester urethanes) (SPEU) with high hard segment content was synthesized and physicochemically characterized. The materials with higher thermal stability were processed into homogeneous filaments by hot‐melt extrusion with no need for additives nor plasticizers. These filaments were evaluated for FDM, and structures with controlled porosity, filament diameter, and in‐plane pore size could be easily obtained by modifying the printing parameters. Regarding SPEU mechanical properties, the obtained scaffolds could be promising for cartilage tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

Novel three‐dimensional printing of poly(ester urethane) scaffolds for biomedical applications

Lores

Hung

Talou

et al. 2021

Polymers for Advanced Techs

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“…The specimens were taken from a population of patients with ages ranging from 45 to 60 years. The specimens were biaxially tested with a custom traction machine (Figure 3) (Gasparotti et al, 2018). Briefly, the square specimens were mounted on the biaxial tensile testing device using four pneumatic grippers for each side.…”

Section: Methodsmentioning

confidence: 99%

Modeling biomechanical interaction between soft tissue and soft robotic instruments: importance of constitutive anisotropic hyperelastic formulations

Vignali

Gasparotti

Capellini

et al. 2020

The International Journal of Robotics Research

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Cardiovascular diseases are the leading cause of death in the western countries. Robotic surgery recently emerged as a confirmed strategy in the cardiovascular field, especially thanks to the improvement of soft robotics. These techniques have demonstrated their potential in terms of speed of execution and precision. In this context, a deeper knowledge of the material properties of the blood vessels is required, especially for computational soft robotics applications. A constitutive model including the contribution of the collagen fibers families is needed to take hyperelasticity and anisotropy into account. For this purpose, four different models are presented: two fiber families with dispersion (2FFD), two fiber families without dispersion (2FF), four fiber families with dispersion (4FFD), and four fiber families without dispersion (4FF). A set of experimental biaxial data obtained from ex-vivo specimens was used to assess the model performances. Two fitting procedures were imposed: a procedure with no weighting of scores and a procedure with a weight set to enhance the model performances in the contact range. A finite element simulation of a contact procedure was developed to evaluate the effect on the contact pressures and forces according to the different model implementations. In particular, a minimally invasive aortic valve positioning process through a previously designed soft robot was simulated. The results confirmed the overall fitting procedure. The adoption of the weighting process for the fitting was successful, as it permitted an accurate prediction in the region of interest through models with less parameters.

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“…Within this exciting context, 3D printing is a key tool for researchers. The topic has been recently reviewed by Heinrich et al [219] Starting from the initial concept of bone tissue printing, [220] it has been possible to expand this technology to more advanced systems, such as synthetic cartilage, [221,222] skin, [223] heart valve, [224][225][226] entire organs, [168,207,227,228] neuronal [229] and vascular [230,231] networks and supports for medical surgery. [232,233] The example reported by the team of Prof. McAlpine [234] is an outstanding representation of an hybrid approach bridging Printing Biology and Bioprinting that leverages 3D printing for printing bionic objects from inks containing living cells and molecules that tune the ink physicochemical properties and support the biological systems during the printing process.…”

Section: Biocompatible Scaffoldsmentioning

confidence: 99%

Artificial Biosystems by Printing Biology

Arrabito

Ferrara

Bonasera

et al. 2020

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The continuous progress of printing technologies over the past 20 years has fueled the development of a wide plethora of applications in materials sciences, flexible electronics and biotechnologies. More recently, printing methodologies have started up to explore the world of Artificial Biology, offering new paradigms in the direct assembly of Artificial Biosystems (small condensates, compartments, networks, tissues and organs) by mimicking the result of the evolution of living systems and also by redesigning natural biological systems, taking inspiration from them. This recent progress is reported in terms of a new field here defined as Printing Biology, resulting from the intersection between the field of printing and the bottom up Synthetic Biology. Printing Biology explores new approaches for the reconfigurable assembly of designed lifelike or life-inspired structures. This review presents this emerging field, highlighting its main features, i.e. printing methodologies (from 2D to 3D), molecular ink properties, deposition mechanisms, and finally the applications and future challenges. Printing Biology is expected to show a growing impact on the development of biotechnology and lifeinspired fabrication. Printing Biology employs different technologies dispensing molecular inks with tunable composition (molecules, polymers, biomolecules) and drop sizes (from nano-up to macroscale) onto solids or into liquids to develop lifelike or life-inspired artificial biosystems (from small condensates, to compartments up to networks, tissues and organs). This work reviews the extraordinary potential of this emerging research field.

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A 3D printed melt-compounded antibiotic loaded thermoplastic polyurethane heart valve ring design: an integrated framework of experimental material tests and numerical simulations

Cited by 31 publications

References 23 publications

Novel three‐dimensional printing of poly(ester urethane) scaffolds for biomedical applications

Novel three‐dimensional printing of poly(ester urethane) scaffolds for biomedical applications

Modeling biomechanical interaction between soft tissue and soft robotic instruments: importance of constitutive anisotropic hyperelastic formulations

Artificial Biosystems by Printing Biology

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