A 3D printed three-dimensional centrifugal fluidic system for blood separation

Qin, Xianming; Chen, Hualing; Jia, Shuhai; Wang, Wanjun

doi:10.1007/s00542-020-05012-3

Cited by 4 publications

(6 citation statements)

References 26 publications

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“…Qi et al. [ 95 ] constructed a centrifugal microfluidic platform using 3D printing technology with polymers as structural materials, and electrospun fibers were utilized as a filter for white cells. The system can be entirely 3D printed as a whole piece, which can help to prevent any possible sample leakage.…”

Section: Applicationsmentioning

confidence: 99%

“…[91][92][93][94] For a 3D-printed device, electrospun fibers were also applied as a functional unit for certain applications. [95]…”

Section: Combination Use Of Different Components Prepared By Electros...mentioning

confidence: 99%

“…[144] In a centrifugal platform, forces can be controlled by simply manipulating the direction and rotational speed of the motor driving platform. Qi et al [95] constructed a centrifugal microfluidic platform using 3D printing technology with polymers as structural materials, and electrospun fibers were utilized as a filter for white cells. The system can be entirely 3D printed as a whole piece, which can help to prevent any possible sample leakage.…”

Section: Blood Separationmentioning

confidence: 99%

“…• Scaffolds with complex 3D geometries and personalized structure • Scaffolds with enhanced functionality and extensive applications -lab-on-chip device, [89,91] blood separation, [95] dentistry, [189,190] Cell culture and online detection, [92,94] bone repair, [90,165,194] cartilage repair, [86,181,182] tracheal repair, [87,88,110] skeletal muscle regeneration [223] Platforms combining 3D printing and electrospinning techniques…”

Section: Yesmentioning

confidence: 99%

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Combination of 3D Printing and Electrospinning Techniques for Biofabrication

Fazal

Wang

Radacsi

2022

Adv Materials Technologies

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This review presents the different combination methods of 3D printing and electrospinning processes and discusses the advantages of each method. Also, the applications of products of the hybrid process in the biomedical field, including tissue engineering and regenerative medicine, are thoroughly discussed. 3D printing and electrospinning are separate approaches for generating structured materials in a variety of biomedical applications. However, some shortfalls, such as the low resolution of 3D printing and uncontrollable shape of electrospun products, limits their application performances. Therefore, new ideas that combine 3D printing and electrospinning methods are proposed to give full play to their strengths and mitigate their weaknesses, which provide an effective and powerful platform for fabricating novel structural materials. Finally, a future vision regarding challenges and perspectives in the combination of 3D printing and electrospinning techniques is proposed.

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Section: Applicationsmentioning

confidence: 99%

“…[91][92][93][94] For a 3D-printed device, electrospun fibers were also applied as a functional unit for certain applications. [95]…”

Section: Combination Use Of Different Components Prepared By Electros...mentioning

confidence: 99%

Section: Blood Separationmentioning

confidence: 99%

Section: Yesmentioning

confidence: 99%

See 2 more Smart Citations

Combination of 3D Printing and Electrospinning Techniques for Biofabrication

Fazal

Wang

Radacsi

2022

Adv Materials Technologies

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“…However, the use of 3D printing technology is slowly starting to gain importance in this field. Approaches such as the high-efficiency hydrophobic plasma separator developed by Liu et al [18] using a 200 µL input of a blood sample from Schistosoma mansoni, or the 3D-printed microfluidic device for plasma separation based on centrifugal forces developed by Qin et al [19] using a 300 µL input of a pig blood sample are a few examples found in the literature. However, the lack of testing with human whole blood hinders their applicability for biomedical testing.…”

Section: Introductionmentioning

confidence: 99%

High-Resolution 3D Printing Fabrication of a Microfluidic Platform for Blood Plasma Separation

et al. 2022

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Additive manufacturing technology is an emerging method for rapid prototyping, which enables the creation of complex geometries by one-step fabrication processes through a layer-by-layer approach. The simplified fabrication achieved with this methodology opens the way towards a more efficient industrial production, with applications in a great number of fields such as biomedical devices. In biomedicine, blood is the gold-standard biofluid for clinical analysis. However, blood cells generate analytical interferences in many test procedures; hence, it is important to separate plasma from blood cells before analytical testing of blood samples. In this research, a custom-made resin formulation combined with a high-resolution 3D printing methodology were used to achieve a methodology for the fast prototype optimization of an operative plasma separation modular device. Through an iterative process, 17 different prototypes were designed and fabricated with printing times ranging from 5 to 12 min. The final device was evaluated through colorimetric analysis, validating this fabrication approach for the qualitative assessment of plasma separation from whole blood. The 3D printing method used here demonstrates the great contribution that this microfluidic technology will bring to the plasma separation biomedical devices market.

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A new expression for inertial particle collection efficiency by nanofibers with slip effect

Yang

Zhu

2022

Chemical Engineering Science

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A 3D printed three-dimensional centrifugal fluidic system for blood separation

Cited by 4 publications

References 26 publications

Combination of 3D Printing and Electrospinning Techniques for Biofabrication

Combination of 3D Printing and Electrospinning Techniques for Biofabrication

High-Resolution 3D Printing Fabrication of a Microfluidic Platform for Blood Plasma Separation

A new expression for inertial particle collection efficiency by nanofibers with slip effect

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