A 4.0-T fMRI study of brain connectivity during word fluency in first-episode schizophrenia

Voxel-wise meta-analysis of fMRI studies in patients at clinical high risk for psychosis

“…46 Similarly, the anterior cingulate has been associated with impairments in emotional processing and higher executive performances (for a review see Baiano and colleagues 47 ). Previous fMRI studies have revealed abnormal anterior cingulate engagement in patients with first-episode psychosis, [48][49][50] patients at high genetic risk for psychosis 51,52 and in high-risk individuals. 10 A recent SDM voxel-based meta-analysis confirmed anterior cingulate (and insular) grey matter reductions in patients with first-episode psychosis, suggesting that the general salience network is abnormal from the early phases of disease.…”

Hemispheric and executive influences on low-level language processing after traumatic brain injury

“…One study which did report increased connectivity in people with schizophrenia described a widespread connectivity map in that group as compared to a more focused map for controls (Boksman et al, 2005). Finally, while studies on normal aging have typically found reductions in functional connectivity for older adults (e.g., Wu et al, 2007), one study has found that even when there is reduced connectivity between some brain areas, there can be other areas of enhancement in functional connectivity.…”

Alterations of fronto-temporal connectivity during word encoding in schizophrenia

“…Jennings et al (1998) used structural equation modeling in a PET study of semantic categorization and found that the influence of left ventral PFC (BA 45) on left STG activity was positive in controls but negative in patients, in the context of equal task-related prefrontal and temporal activation. Boksman et al (2005) used a timeseries covariation approach to examine anterior cingulate (AC) connectivity in an fMRI study of word fluency and observed significant AC-left STG connectivity in patients, but not in controls. In a canonical variates analysis of group PET data during an n-back working memory task, Meyer-Lindenberg et al (2001) found high intra-temporal and low intra-frontal functional correlations in patients, with the reverse finding in controls.…”