A 4-week consumption of medium roast and dark roast coffees affects parameters of energy status in healthy subjects

Riedel, A; Dieminger, Natalie; Bakuradze, Tamara; Lang, Roman; Montoya, G.; Hochkogler, Christina Maria; Winkler, Swantje; Bytof, Gerhard; Lantz, Ingo; Stiebitz, Herbert; Richling, Elke; Hofmann, Thomas; Marko, Doris; Schipp, Dorothea; Raedle, Jochen; Somoza, Veronika

doi:10.1016/j.foodres.2014.04.002

Cited by 12 publications

(21 citation statements)

References 53 publications

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“…The results show that pyrazines from coffee are highly bioavailable and intensively metabolized. This may reduce platelet aggregation, which has already been observed in a human intervention study with coffee drinkers . Further research is required to clarify whether the pyrazines and/or their metabolites are imparting the observed biological effects.…”

Section: Discussionmentioning

confidence: 87%

Alkylpyrazines from Coffee are Extensively Metabolized to Pyrazine Carboxylic Acids in the Human Body

Kremer

Pickard

Stadlmair

et al. 2019

Molecular Nutrition Food Res

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Scope: Coffee is a complex mixture of over 1000 compounds, including diverse heteroaromatic compounds such as alkylpyrazines. Little is known about the intake, metabolism, and bodily distribution of these compounds. Therefore, a human intervention study is conducted to investigate the excretion of alkylpyrazine metabolites in urine after the ingestion of brewed coffee containing alkylpyrazines. Methods and results: After consuming a diet without heat-processed food, ten volunteers consumed 500 mL of freshly brewed coffee prepared from coffee pads, providing intakes of 2-methylpyrazine (2-MeP), 2,5-dimethylpyrazine (2,5-DMeP), and 2,6-dimethylpyrazine (2,6-DMeP) amounting to 17.2, 4.4, and 4.9 µmol, respectively. These alkylpyrazines are metabolized into the corresponding pyrazine carboxylic acids, namely pyrazine-2-carboxylic acid (PA), 5-hydroxypyrazine-2-carboxylic acid (5-OHPA), 5-methylpyrazine-2-carboxylic acid (5-MePA), and 6-methylpyrazine-2-carboxylic acid (6-MePA). In total, 64% of the ingested 2-MeP is excreted as PA, as well as 26% as 5-OHPA, while 91% and 97% of the ingested 2,5-DMeP and 2,6-DMeP are recovered as 5-MePA and 6-MePA, respectively, in urine samples collected after coffee consumption. Conclusion: This study provides evidence that alkylpyrazines are rapidly metabolized into the corresponding carboxylic acids and excreted via urine by humans, which is consistent with earlier rodent studies.

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Section: Discussionmentioning

confidence: 87%

Alkylpyrazines from Coffee are Extensively Metabolized to Pyrazine Carboxylic Acids in the Human Body

Kremer

Pickard

Stadlmair

et al. 2019

Molecular Nutrition Food Res

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“…Interestingly, 4-week periods are commonly used for both exposition and washout phases in caffeine-related research. 57,58 As the half-life of caffeine is 4 to 6 hours, the timing of intake could also be important in the manifestation of LUTS. 59 Also, assessing T A B L E 4 Research gaps and future research recommendations following the PICO framework…”

Section: Discussionmentioning

confidence: 99%

“…In addition, intervention studies with more than 4‐week follow‐up periods were more likely to report symptom improvement than others. Interestingly, 4‐week periods are commonly used for both exposition and washout phases in caffeine‐related research 57,58 . As the half‐life of caffeine is 4 to 6 hours, the timing of intake could also be important in the manifestation of LUTS 59 .…”

Section: Discussionmentioning

confidence: 99%

What do we really know about the role of caffeine on urinary tract symptoms? A scoping review on caffeine consumption and lower urinary tract symptoms in adults

Berre

Presse

Morin

et al. 2020

Neurourology and Urodynamics

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Aims The purpose of this scoping review was to map out the existing literature on caffeine intake and lower urinary tract symptoms (LUTS) in adults. Methods In this scoping review, we searched for all studies available until June 2019 in MEDLINE, Embase, CINAHL, Cochrane Central Register, PsycINFO, LILACS, LiSSa, Web of Science, and Joanna Briggs Institute electronic databases, in addition to a hand search of the bibliographies of all relevant articles and a gray literature search. Both intervention studies on the effects of caffeine reduction in adults with LUTS and observational studies on the association between caffeine intake and LUTS‐related outcomes in adults were included and assessed for methodological quality by two independent reviewers. Results Fourteen intervention and 12 observational studies were included. Overall, there was a decrease in urgency episodes (level of evidence 2, grade of recommendation B) and nocturnal enuresis episodes (4, C) with caffeine reduction. Observational studies reported an unclear association between caffeine intake and LUTS‐related outcomes. Most importantly, this present review highlighted high heterogeneity in the studied populations, caffeine measures, and reported outcomes. There was also unknown or high risk of bias in most identified studies. Conclusions Caffeine reduction appears to reduce LUTS. Future studies on caffeine reduction interventions should target populations with urgency and urge urinary incontinence, which show the most promising results, and include valid and reliable measures of caffeine intake and LUTS. Finally, future studies should also use reporting guidelines to ensure lower risk of bias.

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“…Caffeine and other methylxanthines, for example, had already been recognized as nonspecific inhibitors at the time of phosphodiesterase discovery [ 6 , 7 ]. Coffee has been shown to have both in-vitro and in-vivo PDE-inhibiting effects [ 8 , 9 , 10 ]. Furthermore, some classes of flavonoids (flavonols, flavones, anthocyanins and anthocyanidins, flavanones, and flavanonols) have shown PDE-inhibiting potential, whereas catechins are not potent PDE inhibitors [ 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Cyclic Adenosine Monophosphate-Specific Phosphodiesterase by Various Food Plant-Derived Phytotherapeutic Agents

et al. 2017

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Background: Phosphodiesterases (PDEs) play a major role in the regulation of cyclic adenosine monophosphate (cAMP)- and cyclic guanosine monophosphate (cGMP)-mediated pathways. Their inhibitors exhibit anti-inflammatory, vasodilatory and antithrombotic effects. Therefore, consumption of foods with PDE-inhibiting potential may possess beneficial influence on the risk of cardiovascular diseases. Methods: Four plant extracts (Arbutus unedo, Camellia sinensis, Cynara scolymus, Zingiber officinale) with promising ingredient profiles and physiological effects were tested for their ability to inhibit cAMP-specific PDE in vitro in a radioactive assay. Results: Strawberry tree fruit (Arbutus unedo) and tea (Camellia sinensis) extracts did not inhibit PDE markedly. Alternatively, artichoke (Cynara scolymus) extract had a significant inhibitory influence on PDE activity (IC50 = 0.9 ± 0.1 mg/mL) as well as its flavone luteolin (IC50 = 41 ± 10 μM) and 3,4-dicaffeoylquinic acid (IC50 > 1.0 mM). Additionally, the ginger (Zingiber officinale) extract and one of its constituents, [6]-gingerol, significantly inhibited PDE (IC50 = 1.7 ± 0.2 mg/mL and IC50 > 1.7 mM, respectively). Crude fractionation of ginger extract showed that substances responsible for PDE inhibition were in the lipoid fraction (IC50 = 455 ± 19 μg/mL). Conclusions: A PDE-inhibitory effect was shown for artichoke and ginger extract. Whether PDE inhibition in vivo can be achieved through ingestion of artichoke or ginger extracts leading to physiological effects concerning cardiovascular health should be addressed in future research.

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A 4-week consumption of medium roast and dark roast coffees affects parameters of energy status in healthy subjects

Cited by 12 publications

References 53 publications

Alkylpyrazines from Coffee are Extensively Metabolized to Pyrazine Carboxylic Acids in the Human Body

Alkylpyrazines from Coffee are Extensively Metabolized to Pyrazine Carboxylic Acids in the Human Body

What do we really know about the role of caffeine on urinary tract symptoms? A scoping review on caffeine consumption and lower urinary tract symptoms in adults

Inhibition of Cyclic Adenosine Monophosphate-Specific Phosphodiesterase by Various Food Plant-Derived Phytotherapeutic Agents

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