A 41-Year-Old Woman With Severe Dyspnea and Painful Oral Mucosal Ulcerations

Many Faces of Bronchiolitis and Organizing Pneumonia

“…84 Bronchiolitis obliterans is a well-recognized association with PNP. [85][86][87][88][89] In a series of 104 cases, 84 BO occurred in 20 patients, and 16 of 40 patients (40%) with fatal outcome died of BO. In another series of 48 Japanese patients, antiepiplakin (originally identified as an autoantigen in a patient) antibodies were significantly associated with the presence of bronchiolitis obliterans.…”

Recalcitrant paraneoplastic pemphigus associated with follicular dendritic cell sarcoma: response to prolonged rituximab and ciclosporin therapy

“…1 FDCS-associated PNP was reported to have a dismal outcome, with virtually no responses to highdose corticosteroids, plasmapheresis and intravenous immunoglobulin. 2 Rituximab had also been reported ineffective. 2,3 For the first time, we controlled FDCS-associated PNP with rituximab, although others had so far failed.…”

“…2 Rituximab had also been reported ineffective. 2,3 For the first time, we controlled FDCS-associated PNP with rituximab, although others had so far failed. 2,3 Two factors might be involved.…”

“…2,3 For the first time, we controlled FDCS-associated PNP with rituximab, although others had so far failed. 2,3 Two factors might be involved. First, our patient showed very little response to four courses of rituximab (cumulative dose: 1.5 g/m 2 ), a conventional dosage adopted for PNP and pemphigus vulgaris.…”

“…acute hyponatraemia, brain cells adapt to the altered osmolality by the loss of solutes, followed by osmotic movement of water out of the cells. 2 When the sodium is corrected, this process occurs in the reverse. With rapid correction of hyponatraemia, there is further osmotic fluid shift from intracellular to extracellular, resulting in volume loss and, potentially, cell death.…”