A 47-Year-Old Hispanic Man Who Developed Cutaneous Vasculitic Lesions and Gangrene of the Toes Following Admission to Hospital with COVID-19 Pneumonia

Adekiigbe, Riliwan; Ugbode, Franklin; Seoparson, Sunil; Katriyar, Neeraj; Fetterman, Alan D.

doi:10.12659/ajcr.926886

Cited by 9 publications

(8 citation statements)

References 13 publications

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“…There are case reports documenting the presence of COVID-19 with cutaneous vasculitis - severe respiratory failure with ARDS developed in a patient with lower limb vasculitic purpura [ 103 , 104 ], a bullous haemorrhagic rash that progressed to necrotic lesions with histopathology confirmed vasculitis of small- and medium-sized cutaneous vessels [ 105 ], purple palpable papules and haemorrhagic blisters characterised histologically as leucocytoclastic vasculitis [ 106 ], and cutaneous vasculitic lesions and gangrene [ 107 ]. Camprodon Gómez et al [ 108 ] and Mayor-Ibarguren [ 105 ] both described patients with leucocytoclastic vasculitis with positive SARS-CoV-2 PCR in skin biopsies with positive serum IgM and IgG against SARS-CoV-2 but negative oropharyngeal swab PCR.…”

Section: Resultsmentioning

confidence: 99%

Rheumatological complications of Covid 19

Zacharias

Dubey

Koduri

et al. 2021

Autoimmunity Reviews

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Introduction COVID-19 has caused unprecedented hardships in the 21st century with more than 150 million infections. Various immunological phenomena have been described during the course of the infection, and this infection has also triggered autoimmunity. Rheumatological illnesses have been described following resolution of the acute infection; hence we sought to conduct a review of the rheumatological complications of COVID-19. Methods We conducted a literature search for articles relating to sequelae of COVID-19 from Jan 2020 to 30th April 2021. Results We found a number of reports of inflammatory arthritis after SARS-CoV-2 infection. SLE and renal disease have been described, and vasculitis also appears to be a common complication. Rhabdomyolysis and myositis has also been reported in a number of patients. We also found some evidence of large vessel vasculitis in ‘long COVID’ patients. Conclusions This review highlights a number of important complications such as inflammatory arthritis, lupus-like disease, myostis and vasculitis following SARS-CoV-2 infection.

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Section: Resultsmentioning

confidence: 99%

Rheumatological complications of Covid 19

Zacharias

Dubey

Koduri

et al. 2021

Autoimmunity Reviews

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“…One COVID‐19‐positive patient was reported to have an evolving eruption which started out as a maculopapular exanthem with vesicular dermatitis on the acral surfaces, but weeks later, tense bullae consistent with classic bullous pemphigoid were developed 30 . The more recent reports documenting laboratory‐confirmed SARS‐CoV‐2 infection can be seen in Table 5 30–42 . Although more reports have emerged, there is still limited evidence‐based reports regarding the predictive prognosis and significance of timeline of these dermatologic signs.…”

Section: Discussionmentioning

confidence: 99%

“…30 The more recent reports documenting laboratory-confirmed SARS-CoV-2 infection can be seen in Table 5. [30][31][32][33][34][35][36][37][38][39][40][41][42] Although more reports have emerged, there is still limited evidence-based reports regarding the predictive prognosis and significance of timeline of these dermatologic signs.…”

Section: Discussionmentioning

confidence: 99%

A systematic review of dermatologic manifestations among adult patients with COVID‐19 diagnosis

Schwartzberg

Advani

Clancy

et al. 2021

Skin Health and Disease

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Background: Infection with COVID-19 is characterized by respiratory, gastrointestinalandneurologicsymptoms.However,limitedevidenceexistsof the involvement of the integumentary system among COVID-19 patients and evidence suggests that these symptoms may even be the first presenting sign. Objective: To systematically evaluate the literature published on dermatologic signs of COVID-19 in order to educate doctors about the dermatologic signs of COVID-19 infection. Methods: Lit COVID, World Health Organization COVID-19 database and PubMed were searched using terminology to identify adult patients with confirmed COVID-19 infection and dermatologic manifestations of disease. The last search was completed on 13 July 2020. Results: There were 802 reports found. After exclusion, 20 articles were found with 347 patients with confirmed COVID-19 infection. Within these articles, 27 different skin signs were reported. Limitations: Limitations of this review include the recency of COVID-19 infection; so, there are limited published reports and that many reports are not by dermatologists, and so, the cutaneous signs may be misdiagnosed or misdescribed. Conclusion: Dermatologic manifestations of COVID-19 may be the first presenting sign of infection; so, dermatologists and doctors examining the skin should be aware of the virus's influence on the integumentary system in order to promptly diagnose and treat the infected patients. K E Y W O R D S evidence-based dermatology, infection, virologyThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…43,73,77,78 Besides that, in several reports, venous gangrene following extensive venous thrombosis has been described. [79][80][81] In some of the patients, concurrently elevated antiphospholipid antibodies have been detected, possibly contributing to thrombus formation. 43,75,79 Therapeutic attempts with lowmolecular-weight heparin have not always been successful in preventing complete limb ischemia.…”

Section: "True" Acral Ischemiamentioning

confidence: 99%

Microvascular Skin Manifestations Caused by COVID-19

Gawaz

Guenova

2021

Hamostaseologie

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Hypercoagulability and vascular injury, which characterize morbidity in COVID-19 disease, are frequently observed in the skin. Several pathomechanisms, such as inflammation caused by angiotensin-converting enzyme 2–mediated uptake into endothelial cells or SARS-CoV-2-initiated host immune responses, contribute to microthrombus formation and the appearance of vascular skin lesions. Besides pathophysiologic mechanisms observed in the skin, this review describes the clinical appearance of cutaneous vascular lesions and their association with COVID-19 disease, including acro-ischemia, reticular lesions, and cutaneous small vessel vasculitis. Clinicians need to be aware that skin manifestations may be the only symptom in SARS-CoV-2 infection, and that inflammatory and thrombotic SARS-CoV-2-driven processes observed in multiple organs and tissues appear identically in the skin as well.

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A 47-Year-Old Hispanic Man Who Developed Cutaneous Vasculitic Lesions and Gangrene of the Toes Following Admission to Hospital with COVID-19 Pneumonia

Cited by 9 publications

References 13 publications

Rheumatological complications of Covid 19

Rheumatological complications of Covid 19

A systematic review of dermatologic manifestations among adult patients with COVID‐19 diagnosis

Microvascular Skin Manifestations Caused by COVID-19

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