A 99mTc generator using a new inorganic polymer adsorbent for (n, γ) 99Mo

Production of99Mo for Nuclear Medicine by100Mo(n,2n)99Mo

“…First, the production of 99 Mo by neutron activation of enriched 98 Mo targets has been demonstrated to be an attractive alternative, 7) although the specific activity of 99 Mo is low because of the small neutron capture cross section at the thermal neutron energy, 0.14 b. 10) Here, it is worth mentioning that since a method of recovering 99 Mo of thus obtained low to medium specific activity 7 -15 GBq/g, is available using such as a molybdenum-zirconium gel, 11) a new adsorbent named PZC (Poly Zirconium Compound), 12) and a tiny column of a strong base anion-exchanger (Dowex Tc due to their low cross sections of 130 mb at 30 < E p < 50 MeV, which covers the region of the maximum of the excitation function, and of lower than 0.2 mb at 6 < E p < 65 MeV, respectively. The yield calculation by 100 Mo(p; 2n) 99m Tc at 7 < E p < 17 MeV using a highly enriched 100 Mo target gives 300 MBq/(mA h), in which the target thickness is rather thin, about 0.52 g 100 Mo/cm 2 (metallic), 14) due to an energy loss of a proton in the target.…”

The Use of Sodium Hypochlorite Solution for (n,&gamma;)⁹⁹Mo/^99mTc Generator Based on Zirconium-Based Material (ZBM)

“…The mechanism of Mo adsorption into zirconium material has been explained by several sources as occuring through an ion exchange reaction between molybdate ion and chloride ion on the surface of the material as depicted in Fig. 1 [18,22]. The amount of Mo adsorbed into the ZBM depends on the number of Cl atoms bound into the zirconium atom in the molecule.…”

“…The low specific radioactivity of 99 Mo can be overcome with the use of materials having high adsorption capacity of molybdate ion. Tanase et al reported that a titania organic polymer (Poly Zirconium Compound) adsorbent is able to adsorb more than 250 mg Mo of 1 g adsorbent with low activity of 99 Mo [18]. The weaknesses of this material was that it is fragile and less hard, and it reduces the 99 Mo adsorption capacity if the activity of the 99 Mo used is high.…”

“…Since a few years ago, the Centre for Radioisotopes and Radiopharmaceuticals Technology (CRRT), National Nuclear Energy Agency (BATAN) has been developing the synthesis of Zirconium-Based Material (ZBM), as an adsorbent for 99 Mo/ 99m Tc generator, using a modified synthesis method that was previously developed by Tanase et al [18]. Rohadi et al [19] reported that the synthesized ZBM was able to absorb 99 Mo with a capacity of up to ~ 183 mg Mo/g ZBM.…”

Sorption of99MoO42-ions on commercial hydrotalcites

“…When 99 Mo is adsorbed on alumina packed in a column, the 99m Tc can be separated from the column by elution with a 0.9% NaCl solution. This last description corresponds to well known devices called technetium generators [1][2][3] which are widely used in nuclear medicine as a diagnosis tool. Looking for other materials to bear the 99 Mo, Serrano et al [4] investigated the use of hydrotalcite (HT) as 99 Mo support to develop a new technetium generator.…”