2020
DOI: 10.22159/ijap.2020v12i2.36220
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A a Comparative Study of Quality Control Testing on Candesartan Cilexetil Conventional Tablets in Iraq

Abstract: Objective: The present study was performed to compare the quality of conventional tablets loaded with candesartan cilexetil. The selected candesartan cilexetil tablets were commercialized in the Iraq market and produced by different companies.  Methods: Different batches of candesartan cilexetil oral tablets (the concentration of candesartan was 8 mg) were subjected to quality control tests. Tests included weight variation, friability, hardness, drug content, disintegration time and in vitro release stud… Show more

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Cited by 4 publications
(3 citation statements)
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“…In several prior studies, a hardness value between 5 to 7 kg/cm 2 was used as optimum amount for developing tablet formulations. 20,21 However, in current study as the formulated core tablets will be subjected to coating process, a hardness value of 7-8 kg/cm 2 was desired so that the tablets can withstand the coating stress. Since the intention of the formulation was to deliver the drug molecule effectively at colon, it was intended to have a maximum amount of drug release which was considered as response 2.…”
Section: Preparation Of Mesalazine Core Tabletmentioning
confidence: 97%
“…In several prior studies, a hardness value between 5 to 7 kg/cm 2 was used as optimum amount for developing tablet formulations. 20,21 However, in current study as the formulated core tablets will be subjected to coating process, a hardness value of 7-8 kg/cm 2 was desired so that the tablets can withstand the coating stress. Since the intention of the formulation was to deliver the drug molecule effectively at colon, it was intended to have a maximum amount of drug release which was considered as response 2.…”
Section: Preparation Of Mesalazine Core Tabletmentioning
confidence: 97%
“…Pharmaceutical nanosuspensions are aqueous dispersions of insoluble drug particles that are nanosized and stabilized by surfactants. Nanoparticles, on the other hand, are drug carriers that are either polymeric or lipid colloidal [3][4][5]. When a drug molecule has several limitations, such as the inability to form salt, high molecular weight, dose, log P and melting point, nanosuspension is the only choice accessible [6].…”
Section: Introductionmentioning
confidence: 99%
“…Standardization and quality control of plant-based herbal medication by utilizing modern apparatus and utilization of suitable standards is constantly emphasized by WHO [6]. Quality control of herbal medication is a significant process of the pharmaceutical companies, which is mentioned as all should be embraced to promise the purity and uniformity of marketed pharmaceuticals [7]. The development of this polyherbal formulation into a suitable drug delivery system in the form of a tablet was looked to be of suitable pharmacopeial quality and would have comparable release profiles of the conventional dosage form.…”
Section: Introductionmentioning
confidence: 99%