A. A. Ukhtomskii and the reflex theory of behavior

Kruglikov, R. I.

doi:10.1007/bf01185365

Cited by 1 publication

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“…At the same time, analysis of the seleptine effect on CAAR attests to its possible effect on the cerebral transmitter systems, that provide the emotion-motivation basis of a pm~icular CAAR. It is tempting to suppose that seleptine has adrenolytic properties, because h~jection of the neurotoxin 6-hydroxydopamine into the locus coeruleus or its electrolytic destruction results in anmesia, retardation of training for electrodefensive tasks, and disturbances in the retrieval of memm2J trace [2], while the development of CAAR is strongly affected [3]. The effect of seleptine on serotoninergic system is also possible: an increase in the cerebral serotonin content impairs the learning and amnesia of developed CR [2,3], and to a greater extent degree it disturbs consolidation of temporal connection [3/.…”

Section: Resultsmentioning

confidence: 99%

“…It is tempting to suppose that seleptine has adrenolytic properties, because h~jection of the neurotoxin 6-hydroxydopamine into the locus coeruleus or its electrolytic destruction results in anmesia, retardation of training for electrodefensive tasks, and disturbances in the retrieval of memm2J trace [2], while the development of CAAR is strongly affected [3]. The effect of seleptine on serotoninergic system is also possible: an increase in the cerebral serotonin content impairs the learning and amnesia of developed CR [2,3], and to a greater extent degree it disturbs consolidation of temporal connection [3/. Parallel neurochemical studies showed that ill addition to a high affinity for benzodiazepine receptors, seleptine competitively replaces the agonists of serotonin receptors, but not the antagonists of ~x~-or agonists of ~2-adrenoreceptors.…”

Section: Resultsmentioning

confidence: 99%

“…Retention of the conditioned response was assessed in the test of repeated training for the same task to the score achieved in the first session. After oral seleptine (100 mg/kg), the retention of the active avoidance task was deteriorated to a greater extent than the ability for a new learning.Key Words: seleptine; neuroleptics; avoidance response As all conditioned responses (CR) developed by negative reinforcement, two-way active avoidance (AA) in a shuttlebox is controlled by endogenous substances that determine the emotion-motivational status of experimental animals [3]. Logically, chemical agents that decrease motivation level of response (neuroleptics and tranquilizers) impede learning and disturb consolidation of the memory trace [1].…”

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Effect of seleptine on retrieval of active avoidance task in rats

Nikushkin

Chernov

1998

Bull Exp Biol Med

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We have examined seleptine, a new derivative of the atypical neuroleptic clozapinum, on the retrieval of the active avoidance task in rats placed in a shuttlebox. Retention of the conditioned response was assessed in the test of repeated training for the same task to the score achieved in the first session. After oral seleptine (100 mg/kg), the retention of the active avoidance task was deteriorated to a greater extent than the ability for a new learning.Key Words: seleptine; neuroleptics; avoidance response As all conditioned responses (CR) developed by negative reinforcement, two-way active avoidance (AA) in a shuttlebox is controlled by endogenous substances that determine the emotion-motivational status of experimental animals [3]. Logically, chemical agents that decrease motivation level of response (neuroleptics and tranquilizers) impede learning and disturb consolidation of the memory trace [1]. Our aim was to study the effect of the putative tran-a new structural analog of clozapinum (azaleptine, an atypical benzodiazepine neuroleptic), on retention and repeated training for the conditioned active avoidance response (CAAR). MATERIALS AND METHODSMale Wistar rats with (body weight 230-260 g) were trained for CAAR in the shuttlebox of a Reflex-6 system (Columbus Instruments Inc.). The rats were trained for AA task by the modified method [4] to 10 successive correct avoidance responses. The conditioned stimulus was a 5-sec tone. The unconditioned stimulus was a footshock with the strength Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, Moscow tuned individually for each rat. The period of combined presentation of conditioned and unconditioned stimuli was no longer than 15 sec; the interval between the combined stimuli was 20-40 sec. During a single session the rats were subjected to no more than 40 footshocks. If this criterion was not achieved, the rat was discarded. Only 61% of the tested rats acquired this reflex.The state of the temporal connection was assessed according to the retrieval of AA task after the second session: 7 days after acquisition of CAAR the rats were trained to the same score of 10 successive correct responses. Retention (R) of CR was calculated from the following formula R=(A-B)/A• 100%, where A and B are the numbers of combined stimuli presented to develop CR in the first and second session, respectively. Seleptine was synthesized at the Novokuznetsk Chemical-Pharmaceutical Institute. Water solution of seleptine (10, 30, and 100 mg/kg) was administered orally 30 or 60 rain prior to the second training session for CAAR. The total volume of liquid was no more than 0.5 ml. During the same period the control rats were treated with 0.5 ml saline. Each rat was tested only once, every group consisted of 7 rats. The results were statistically analyzed using nonparametric one-factor analysis for independent variants (Kruskal-Wallis test).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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