This is a study focused on circulatory system of music therapy on vegetative state patient after a consecutive 41-day experiment. In this study, Mahler's symphony no.2 was used for this music therapy. Mahler's symphony no.2, Resurrection, is good for music therapy. With various elements in Mahler's second symphony, with string, wind, drum, and even voice; providing a strong and dynamic stimulation. There are some significant changes after 14-day stimulation: both the standard deviation of time sequence (SDNN) of the subject increased while the standard deviation of SDNN (SDNN-std) also increased significantly, indicating the circulatory system the activity of the cardiovascular system was enhanced. As for SDNN, the increase rate is more than 75% from the beginning. Although there's only one subject in this experiment, the significant results are still encouraging. 2011 11th IEEE International Conference on Bioinformatics and Bioengineering 978-0-7695-4391-8/11 $26.00