A Bacteriologic Study of Portal-Vein Blood in Man

Schatten, William E.

doi:10.1001/archsurg.1955.01270150098011

Cited by 93 publications

(25 citation statements)

References 7 publications

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“…23 Also, patients who underwent non-biliary abdominal surgery had a 32% positive rate of bacterial infection in their portal blood. 24 Leung et al 2 found bacteria in 84% of the inner cut surface of the pigmented gallstones but not cholesterol stones using electron microscopy. In this study, bacteria in gallstone were investigated by the amplification of 16SrRNA and DNA sequencing, as others have done recently.…”

Section: Discussionmentioning

confidence: 99%

Identification of Helicobacter pylori in Gallstone, Bile, and Other Hepatobiliary Tissues of Patients with Cholecystitis

Lee

et al. 2010

Gut Liver

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Background/Aims: Bacterial infection is accepted as a precipitating factor in cholesterol gallstone formation, and recent studies have revealed the presence of Helicobacter species in the hepatobiliary system. We utilized the polymerase chain reaction (PCR) to establish the presence of bacterial DNA, including from Helicobacter species, in gallstones, bile juice, and gallbladder mucosa from patients with gallstones. Methods: At cholecystectomy, 58 gallstones, 48 bile samples, and 46 gallbladder mucosa specimens were obtained and subjected to nested PCR using specific 16S rRNA primers of H. pylori and other bacteria. Bacterial species were identified by DNA sequencing analysis. Bacterial 16S rRNA was detected in 25 out of 36 mixed-cholesterol gallstones, 1 out of 10 purecholesterol gallstones, and 9 out of 12 pigmented stones. Furthermore, 16S rDNA sequencing identified Escherichia coli, Pseudomonas, Citrobacter, Klebsiella, and Helicobacter species. Results: Helicobacter DNA was detected in 4 out of 58 gallstones, 6 out of 48 bile samples, and 5 out of 46 gallbladder specimens. Direct sequencing of Helicobacter amplicons confirmed strains of H. pylori in all four gallstones, five out of six bile samples, and three out of five gallbladder specimens. Almost all mixed-cholesterol gallstones appear to harbor bacterial DNA, predominantly E. coli. Conclusions: H. pylori was also found in the biliary system, suggesting that these bacteria are of etiological importance in gallstone formation. (Gut Liver 2010; 4:60-67)

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Section: Discussionmentioning

confidence: 99%

Identification of Helicobacter pylori in Gallstone, Bile, and Other Hepatobiliary Tissues of Patients with Cholecystitis

Lee

et al. 2010

Gut Liver

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“…[28][29] Gastric acid secretion appears to be normal in sickle cell anaemia30 and direct evidence that disease secondary to sickling in the gastrointestinal tract enhances susceptibility to bacteraemia is largely lacking.7 36 But, liver function is often impaired in sickle cell anaemia in childhood3' and structural damage leading to hepatic fibrosis occurs with increasing age.29 32 There is also experimental evidence in animals that morbidity from salmonella infection is enhanced by haemolysis with or without anaemia.33…”

Section: Discussionmentioning

confidence: 99%

Salmonella osteomyelitis in childhood. A report of 63 cases seen in Nigerian children of whom 57 had sickle cell anaemia.

Adeyokunnu¹,

Hendrickse²

1980

Archives of Disease in Childhood

129

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SUMMARY A review of 63 Nigerian children with salmonella osteomyelitis showed that in all but 2 ofthem the disease occurred in association with HbS either in the homozygous state (57 patients) or in heterozygous combination with other haemoglobins (4 patients). Osteomyelitis was most prevalent during the first 2 years of life, and boys were more often affected than girls. In the majority, multiple sites were involved and lesions were usually bilateral and often symmetrical. Salmonella sp. was isolated from blood or pus, or both, in all patients. In some patients additional pathogens were also isolated from blood or pus. Clinical presentation was variable. In many patients the illness was slight and they were treated entirely as outpatients, but serious toxaemia, severe bone lesions with pathological fractures, and chronic suppuration occurred in others. Most patients responded well to chloramphenicol and conservative management. There were 4 deaths. 17 patients recovered with sequelae.

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“…Many studies have been done and subsequently it has become clear that, in addition to gram-negative bacteria, endotoxin, gram-positive bacteria and fungi can pass through the mucosal barrier. [3][4][5][6][7] Subsequently it has become clear that, in addition to Gram-negative bacteria, endotoxin, Gram-positive bacteria and fungi can pass through the mucosal barrier which has been termed as 'bacterial translocation'. 8 There is no doubt that bacterial translocation occurs in humans.…”

Section: Introductionmentioning

confidence: 99%

Bacterial Translocation as a Cause of Postoperative Sepsis in Surgical Patients Undergoing Laparotomy

Thapa¹,

Hamal

Yadav

et al. 2014

J Lumbini Med Coll

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Introduction: Bacterial translocation is the invasion of indigenous intestinal bacteria through the gut mucosa to normally sterile tissues and the internal organs. Objective of the study is to examine the spectrum of bacteria involved in translocation in surgical patients undergoing laparotomy and to determine the relation between nodal migration of bacteria and the development of postoperative septic complications. Methods: Mesenteric lymph nodes (MLN)culture was done in patients undergoing elective and emergency surgeries fulfilling the inclusion criteria. Results:Bacterial translocation was identified in 22 (44.8%) patients. The most common organism identified was Escherichia coli (n=11, 50%). Both enteric bacteria, typical of indigenous intestinal flora, and non-enteric bacteria were isolated. Postoperative septic complications developed in four (11%) patients. Septic morbidity was more frequent when a greater diversity of bacteria resided within the mesenteric lymph nodes. Conclusion: Bacterial translocation is associated with an increase in the development of postoperative sepsis in surgical patients. The organisms responsible for septic morbidity are similar in spectrum to those observed in the mesenteric lymph nodes. These data strongly support the gut origin hypothesis of sepsis in humans. Besides, there is increased bacterial translocation in patients undergoing emergency procedures. Keywords: bacteria • laparotomy • postoperative • sepsis • translocation

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A Bacteriologic Study of Portal-Vein Blood in Man

Cited by 93 publications

References 7 publications

Identification of Helicobacter pylori in Gallstone, Bile, and Other Hepatobiliary Tissues of Patients with Cholecystitis

Identification of Helicobacter pylori in Gallstone, Bile, and Other Hepatobiliary Tissues of Patients with Cholecystitis

Salmonella osteomyelitis in childhood. A report of 63 cases seen in Nigerian children of whom 57 had sickle cell anaemia.

Bacterial Translocation as a Cause of Postoperative Sepsis in Surgical Patients Undergoing Laparotomy

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