A baicalin-loaded coaxial nanofiber scaffold regulated inflammation and osteoclast differentiation for vascularized bone regeneration

Jin, Shue; Gao, Jing; Yang, Renli; Cheng, Yuan; Wang, Ruili; Zou, Qin; Zuo, Yi; Zhu, Meifang; Li, Yubao; Man, Yi; Li, Jidong

doi:10.1016/j.bioactmat.2021.06.028

Cited by 45 publications

(49 citation statements)

References 56 publications

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“…It is well known that the macrophages and other immune cells usually are recruited to the implantation sites and trigger an inflammatory response, when a foreign man-made scaffold is implanted into the body [ 9 , 57 , 58 ]. Therefore, the ideal engineered scaffolds should promote the regeneration of damaged tissues and reduce the inflammatory response.…”

Section: Resultsmentioning

confidence: 99%

Electrospun strong, bioactive, and bioabsorbable silk fibroin/poly (L-lactic-acid) nanoyarns for constructing advanced nanotextile tissue scaffolds

Liu

Zhang

et al. 2022

Materials Today Bio

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Section: Resultsmentioning

confidence: 99%

Electrospun strong, bioactive, and bioabsorbable silk fibroin/poly (L-lactic-acid) nanoyarns for constructing advanced nanotextile tissue scaffolds

Liu

Zhang

et al. 2022

Materials Today Bio

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“…Moreover, the core–shell structure also made it useful for sustained and long-term release of baicalin, thus further promoting the osteogenic differentiation of MSCs and bone reconstruction. 208…”

Section: Function Regulationmentioning

confidence: 99%

Electrospun nanofibers for bone regeneration: from biomimetic composition, structure to function

et al. 2022

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“…Nowadays, biomaterials are able to accomplish the complex functional demands of different biological fields, including tumor treatment, medical imaging, regulation of immune system, etc. 29 , 30 For example, some microRNA and cytokines have been utilized in conjunction with biomaterials for immunoregulation. 31 , 32 Polyethylene glycol (PEG) modified poly (lactic-co-glycolic acid) (PLGA) is a promising biomedical polymer used to assemble multi-functional platforms.…”

Section: Introductionmentioning

confidence: 99%

PD-1 Targeted Nanoparticles Inhibit Activated T Cells and Alleviate Autoimmunity via Suppression of Cellular Energy Metabolism Mediated by PKM2

Liu¹,

Xu²,

Li³

et al. 2022

IJN

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Background Effector T cells, especially T helper 1 (Th1) cells and T helper 17 (Th17) cells, are involved in the pathogenesis of many autoimmune diseases such as uveitis. Under hyperactive immune conditions, these effector T cells pathologically maintain a high expression level of programmed cell death protein 1 (PD-1) receptors and distinctively engage aerobic glycolysis via cellular energy metabolism mediated by pyruvate kinase M2 (PKM2). Therefore, we proposed that the synergy of metabolic inhibition and receptor guidance might target and down-regulate these hyperactive effector T cells to achieve anti-immune effects. Methods PD-1 antibody and TEPP-46 were integrated by polyethylene glycol (PEG) modified poly (lactic-co-glycolic acid) (PLGA) as a nanoplatform (TPP). Characteristics of TPP were basically detected. The biosafety of TPP was evaluated in vitro and in vivo. The targeting effect of TPP was detected by laser scanning confocal microscopy and flow cytometry (FCM). Interleukin-2 (IL-2)/interleukin-17A (IL-17A)/interferon-gamma (IFN-γ) producing cells were detected by FCM. Experimental autoimmune uveoretinitis (EAU) was induced in C57BL/6J mice as the inflammatory model. Results TPP had homogeneous distribution, good stability in vitro, and high biosafety in vitro and in vivo. Encapsulated TEPP-46 showed a sustained release profile with burst, steady and slow release periods. Early activation and proliferation of effector T cells was inhibited by TPP treatment in vitro. Th1 and Th17 cells were suppressed by TPP in vitro and in vivo. EAU was alleviated in mice by systemic administration of TPP. Conclusion The novel nanoplatform TPP could suppress Th1 and Th17 cells and exhibited an anti-inflammatory effect on EAU, providing an alternative approach to ameliorate autoimmune diseases mediated by these cells.

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A baicalin-loaded coaxial nanofiber scaffold regulated inflammation and osteoclast differentiation for vascularized bone regeneration

Cited by 45 publications

References 56 publications

Electrospun strong, bioactive, and bioabsorbable silk fibroin/poly (L-lactic-acid) nanoyarns for constructing advanced nanotextile tissue scaffolds

Electrospun strong, bioactive, and bioabsorbable silk fibroin/poly (L-lactic-acid) nanoyarns for constructing advanced nanotextile tissue scaffolds

Electrospun nanofibers for bone regeneration: from biomimetic composition, structure to function

PD-1 Targeted Nanoparticles Inhibit Activated T Cells and Alleviate Autoimmunity via Suppression of Cellular Energy Metabolism Mediated by PKM2

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