A basic policy for allergen standardization in our country and standardization of Japanese cedar (Cryptomeria japonica) pollen extracts⁎

Yasueda, Hiroshi; Okuda, Masahiro; Yoshida, Hiroyuki; Itō, Kōji; Baba, Minoru; Likura, Yoji; Okudaira, Hirokazu; Inoue, Sakae; Sakaguchi, Masahiro; Miyamoto, Terumasa

doi:10.2332/allergolint.46.135

Cited by 16 publications

(14 citation statements)

References 4 publications

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“…Values, which were from 9 to 11, 11 to 13, and 13 to 15, were assigned the in vivo allergenic potencies of 1000 JAU/ml, 10,000 JAU/ml, and 100,000 JAU/ml, respectively, based on the plan used in the standardization of JCP allergen vaccines. 11,12 With this method, the same titer could be assigned to extracts with, at the most, a 3 2 -fold (9-fold) difference in allergenic potencies.…”

Section: Intradermal Testingmentioning

confidence: 99%

“…11,12 The protocol for intradermal testing was largely based on the FDA protocol except for criteria for determining the threshold concentration. Briefly, 20 ml of each diluted HDM extract was administered intradermally into the forearm from low to high concentrations using 1-ml tuberculin syringes.…”

Section: Intradermal Testingmentioning

confidence: 99%

“…9 In Japan, the Japanese Society of Allergology (JSA) standardized Japanese cedar pollen (JCP) allergen vaccines. 11,12 In vivo allergenic potency of the JSA reference JCP extract was determined by intradermal testing and measurement of the content of the major allergen Cry j 1 was selected as the surrogate in vitro assay.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Japanese Society of Allergology task force report on standardization of house dust mite allergen vaccines – Secondary publication

Takai

Okamoto

Okubo

et al. 2015

Allergology International

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Section: Intradermal Testingmentioning

confidence: 99%

Section: Intradermal Testingmentioning

confidence: 99%

See 1 more Smart Citation

Japanese Society of Allergology task force report on standardization of house dust mite allergen vaccines – Secondary publication

Takai

Okamoto

Okubo

et al. 2015

Allergology International

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“…Maintenance doses were given at 4-week intervals. The 200-JAU dose of the extract contained 0.06-0.25 μg/ml of Cry j 1 and 0.08-0.31 μg/ml of Cry j 2, which are the major allergens of JCP [17]. …”

Section: Methodsmentioning

confidence: 99%

Japanese Cedar Pollen-Based Subcutaneous Immunotherapy Decreases Tomato Fruit-Specific Basophil Activation

Inuo

Kondo

Tanaka

et al. 2015

Int Arch Allergy Immunol

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Background: Some patients with Japanese cedar pollen (JCP)-induced allergic rhinitis develop pollen-food allergy syndrome (PFAS) as a reaction to tomato fruit. Pollen allergen-specific subcutaneous immunotherapy (SCIT) is reportedly beneficial for some associated food allergies; however, the reported changes in food allergen-specific immunoglobulin (Ig)E and IgG₄ levels are inconsistent. Here, we investigated immunologic reactivity to tomato fruit after JCP-based SCIT. Methods: Twenty-three children (aged 6-17 years) with JCP-induced allergic rhinitis and sensitized to tomato (serum tomato fruit-specific IgE level >0.34 UA/ml) received JCP-based SCIT. Basophil activation by tomato and JCP extracts and serum-specific IgE and IgG₄ levels against these allergens were determined before and after 4 or 5 months of maintenance SCIT. Basophil activation was assessed by monitoring CD203c upregulation on flow cytometry. Results: JCP-based SCIT significantly reduced the basophil activation caused by tomato fruit (p = 0.03) and JCP (p < 0.001) extracts. JCP-specific IgG₄ levels markedly increased after SCIT (p < 0.001), whereas tomato fruit-specific IgG₄ levels did not. After SCIT, no significant changes were observed in specific IgE levels for tomato fruit (p = 0.11) or JCP (p = 0.19). Conclusions: Tomato fruit-specific basophil activation decreases after JCP-based SCIT, suggesting that it is efficacious in relieving and preventing the symptoms of PFAS in patients with JCP-induced allergic rhinitis.

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“…The allergen extracts used in this study were purchased from a commercial company (Greer Laboratory, Lenoir, NC) except for Japanese cedar pollen (Cryptomeria japonica, CJ) antigen, which was prepared as reported previously [19]. Briefly, 8 groups of allergens were used: HDM (Dermatophagoides farina: DF and Dermatophagoides pteronyssinus: DP), arthropods (flea, insect mix), cat epithelia, foods (corn, rice, wheat, beef, milk, egg, etc), mold (Aspergillus mix, Penicillium mix, etc), grasses (Yellow dock, Sage mix, and 7 grass mix), weeds (National weed mix), and trees (Elm mix, Pine mix, Eastern oak mix, and Birch mix).…”

Section: Animalsmentioning

confidence: 99%

Immunological Findings in 3 Dogs Clinically Diagnosed with Allergic Rhinitis

et al. 2004

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ABSTRACT. Three dogs clinically diagnosed with allergic rhinitis (AR) were examined for their immunological findings. House dust mites (HDM) such as Dermatophagoides farinae (DF) and D. pteronyssinus (DP) were identified as positive allergens in the 3 dogs with both intradermal skin test and serum antigen-specific IgE test. Lymphocyte blastogenic response of peripheral blood mononuclear cells (PBMCs) under stimulation with DF antigen in dogs with AR was higher than that in 4 healthy control dogs. Expression level of IL-4 mRNA in PBMCs obtained from the 3 AR dogs was higher than that in PBMCs obtained from 4 healthy control dogs before and after stimulation with DF antigen. Expression level of IFN-γ mRNA in PBMCs was not different between the AR and control dogs before and after stimulation with DF antigen. These results suggested that allergic reaction to HDM antigen and T H 2-type immune response were associated with the development of AR in 3 dogs examined in this study. KEY WORDS: allergic rhinitis, canine, house dust mite, T H 2-type immune response.

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A basic policy for allergen standardization in our country and standardization of Japanese cedar (Cryptomeria japonica) pollen extracts⁎

Cited by 16 publications

References 4 publications

Japanese Society of Allergology task force report on standardization of house dust mite allergen vaccines – Secondary publication

Japanese Society of Allergology task force report on standardization of house dust mite allergen vaccines – Secondary publication

Japanese Cedar Pollen-Based Subcutaneous Immunotherapy Decreases Tomato Fruit-Specific Basophil Activation

Immunological Findings in 3 Dogs Clinically Diagnosed with Allergic Rhinitis

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