2010
DOI: 10.1093/qjmed/hcq142
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A basic smell test is as sensitive as a dopamine transporter scan: comparison of olfaction, taste and DaTSCAN in the diagnosis of Parkinson's disease

Abstract: Our patients with early PD have a frequent and severe olfactory deficit that correlates with disease severity, symptom duration and DaTSCAN but not EGM. The sensitivities of UPSIT and DaTSCAN are high at 86% and 92%, respectively. Although DaTSCAN is superior for 'localization', UPSIT is considerably 'cheaper', and neither is disease specific. EGM threshold impairment in PD is independent of the smell deficit, and probably signifies advanced disease.

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Cited by 97 publications
(127 citation statements)
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“…According to this study, olfactory testing can successfully distinguish PD patients from Non-parkinsonism, which is in line with previous studies [22][23][24][25]. However, olfactory testing fails in distinguishing PD from APS or APS from Non-parkinsonism.…”
Section: Olfactionsupporting
confidence: 91%
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“…According to this study, olfactory testing can successfully distinguish PD patients from Non-parkinsonism, which is in line with previous studies [22][23][24][25]. However, olfactory testing fails in distinguishing PD from APS or APS from Non-parkinsonism.…”
Section: Olfactionsupporting
confidence: 91%
“…However, its specificity was poor (40%) in both cases. These results are comparable to Deeb et al [22] , but not in accordance with other studies where sensitivity and specificity were nearly on the same level [25,30]. A potential explanation for this divergence could depend on cultural biases and odour familiarity.…”
Section: Olfactionsupporting
confidence: 77%
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“…They make it possible to differentiate between persons suffering from PD and healthy individuals as well as to differentiate between various Parkinson's syndromes more accurately than in the case of the motor function [52]. The sensitivity and specificity of the olfactory function tests is in this regard higher than in the case of other diagnostic methods such as PET and SPECT imaging [53]. The inclusion of the olfactory function evaluation increased the accuracy of the PD diagnosis to 90% [15].…”
Section: Differential Diagnosis Of Parkinson's Syndromes Based On Thementioning
confidence: 99%