A benzimidazole scaffold as a promising inhibitor against SARS-CoV-2

Mudi, Prafullya Kumar; Mahanty, Ayan Kumar; Kotakonda, Muddukrishnaiah; Prasad, Sunnapu; Bhattacharyya, Subires; Biswas, Bhaskar

doi:10.1080/07391102.2021.2024448

Cited by 12 publications

(12 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other characteristic stretching frequencies in the range from 3105 to 2900 cm –1 suggest the characteristic stretching frequencies of R1–CH 2 groups. These IR spectral values resemble well with the reported values [ 23 , 30 ]. The solution stabilities of the compounds were assessed by time-dependent UV-Vis spectra in methanol at room temperature for 24h.…”

Section: Resultssupporting

confidence: 91%

“…Very recently, we have designed and synthesized one hydrated phenazine chloride explored their therapeutic characteristics with computational aided drug design and in vitro SARS-CoV-2 screening activities against Vero cell lines [30] . In this context, we have designed and developed three 5-membered heterocycle-substituted benzimidazoles and characterized them with a suite of spectroscopic methods and X-ray structural analysis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In silico anti-SARS-CoV-2 activities of five-membered heterocycle-substituted benzimidazoles

Mudi

Mahato

Verma

et al. 2022

Journal of Molecular Structure

Self Cite

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

In silico anti-SARS-CoV-2 activities of five-membered heterocycle-substituted benzimidazoles

Mudi

Mahato

Verma

et al. 2022

Journal of Molecular Structure

Self Cite

View full text Add to dashboard Cite

“…The synthesized agent revealed 92.4% cell viability (Vero E6) at 9.0 μM concentration in comparison to 99.23% for Remdesivir at 10 μM. The antiviral properties of 17 were supported by the immunofluorescence assay [ 147 ].…”

Section: Synthetic Indole-containing Compoundsmentioning

confidence: 99%

Indole-Based Compounds as Potential Drug Candidates for SARS-CoV-2

Girgis,

Panda,

Kariuki

et al. 2023

Molecules

View full text Add to dashboard Cite

The COVID-19 pandemic has posed a significant threat to society in recent times, endangering human health, life, and economic well-being. The disease quickly spreads due to the highly infectious SARS-CoV-2 virus, which has undergone numerous mutations. Despite intense research efforts by the scientific community since its emergence in 2019, no effective therapeutics have been discovered yet. While some repurposed drugs have been used to control the global outbreak and save lives, none have proven universally effective, particularly for severely infected patients. Although the spread of the disease is generally under control, anti-SARS-CoV-2 agents are still needed to combat current and future infections. This study reviews some of the most promising repurposed drugs containing indolyl heterocycle, which is an essential scaffold of many alkaloids with diverse bio-properties in various biological fields. The study also discusses natural and synthetic indole-containing compounds with anti-SARS-CoV-2 properties and computer-aided drug design (in silico studies) for optimizing anti-SARS-CoV-2 hits/leads.

show abstract

“…Heterocycles are ubiquitous in biologically active compounds, natural products, and common pharmaceuticals [1][2][3][4][5][6][7][8][9], representing a highly privileged structural motif. For example, common biocides [10], fungicides [11], antitumoral agents [12,13], and analgesics [14][15][16], to mention a few, contain a benzimidazole or benzothiazole moiety in their structure.…”

Section: Introductionmentioning

confidence: 99%

Mechanochemistry Frees Thiourea Dioxide (TDO) from the ‘Veils’ of Solvent, Exposing All Its Reactivity

et al. 2023

View full text Add to dashboard Cite

The synthesis of nitrogen-based heterocycles has always been considered essential in developing pharmaceuticals in medicine and agriculture. This explains why various synthetic approaches have been proposed in recent decades. However performing as methods, they often imply harsh conditions or the employment of toxic solvents and dangerous reagents. Mechanochemistry is undoubtedly one of the most promising technologies currently used for reducing any possible environmental impact, addressing the worldwide interest in counteracting environmental pollution. Following this line, we propose a new mechanochemical protocol for synthesizing various heterocyclic classes by exploiting thiourea dioxide (TDO)’s reducing proprieties and electrophilic nature. Simultaneously exploiting the low cost of a component of the textile industry such as TDO and all the advantages brought by a green technique such as mechanochemistry, we plot a route towards a more sustainable and eco-friendly methodology for preparing heterocyclic moieties.

show abstract

A benzimidazole scaffold as a promising inhibitor against SARS-CoV-2

Cited by 12 publications

References 59 publications

In silico anti-SARS-CoV-2 activities of five-membered heterocycle-substituted benzimidazoles

In silico anti-SARS-CoV-2 activities of five-membered heterocycle-substituted benzimidazoles

Indole-Based Compounds as Potential Drug Candidates for SARS-CoV-2

Mechanochemistry Frees Thiourea Dioxide (TDO) from the ‘Veils’ of Solvent, Exposing All Its Reactivity

Contact Info

Product

Resources

About