Additive Manufacturing (AM) is replacing traditional manufacturing approaches-such as subtractive and molding-in some industries. The product and supply chain impacts of AM continue to extend its industrial reach, improve engineer-to-order manufacturing, and pave the way to mass customization. This study explores the supply chain changes that may arise from a full or partial transition to AMbased production. Supply chain factors and dimensions that are greatly impacted are initially identified. Management and operational issues pertinent to each factor are discussed next, followed by a review of the current literature and the future of AM-based supply chains. The interrelationships between these factors are then investigated considering the disruptive impact of AM on supply chain management. Finally, the supply chain change matrix is presented for identifying the areas in that supply chains are expected to be impacted. This chapter is concluded by providing a summary of the findings and insights into AM-based supply chain transition.