A bibliometric analysis of PROTAC from 2001 to 2021

Li, Deping; Yu, Dongmin; Li, Yan; Yang, Renze

doi:10.1016/j.ejmech.2022.114838

Cited by 53 publications

(45 citation statements)

References 141 publications

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“…Bibliometrics provides a statistical cartography of the knowledge structure in a given scientific field. With the capability of processing a large amount of bibliographic data, bibliometric analysis allows us to objectively assess the impact of the contributor and clarify the topics of high interest and the research trends of certain research areas. − This approach’s scientific nature and feasibility have been demonstrated in previous studies. − Concerning research in biochemistry teaching, do Nascimento provided a detailed analysis of the literature published in the Journal of Biochemistry Education . In a recent study, Barbosa performed a comprehensive bibliometric analysis of the literature of all grades of biochemistry education .…”

Section: Introductionmentioning

confidence: 99%

Knowledge-Map Analysis of Undergraduate Biochemistry Teaching Research: A Bibliometric Study from 2012 to 2021

He,

Li,

Chen

et al. 2024

J. Chem. Educ.

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Biochemistry is becoming increasingly crucial for undergraduates majoring in biology, chemistry, agriculture, and medicine. In recent years, much research has been carried out on promoting this course's teaching outcomes. However, the knowledge structure of undergraduate biochemistry teaching research has yet to be formed. Here, 715 validated publications from 2012 to 2021 were retrieved from the Web of Science Core Collection. The annual publications, journals/cited journals, countries, institutions, authors/cited authors, keywords, and cited references were analyzed using CiteSpace. As revealed in our study, the United States is the most productive country, and Biochemistry and Molecular Biology Education, the Journal of Chemical Education, and CBE Life Sciences Education are the most influential journals. Most studies focused on introducing or designing creative laboratory courses to improve students' hands-on abilities. Interestingly, we found that the studies in this period can be divided into two stages: the research topics in the first stage were highly diverse, and in the second stage, the subfield of course-based undergraduate research experiences attracted much attention. Taken together, this study offers insights into the historical development of undergraduate biochemistry educational research, which will have implications for scientists conducting future investigations in this promising field and teachers for better learning outcomes.

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Section: Introductionmentioning

confidence: 99%

Knowledge-Map Analysis of Undergraduate Biochemistry Teaching Research: A Bibliometric Study from 2012 to 2021

He,

Li,

Chen

et al. 2024

J. Chem. Educ.

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“…As a well-established method for analyzing publication information, bibliometric analysis has been widely used in different research areas (13)(14)(15)(16), specifically the identification of bibliometric relevant parameters, such as core scholars/institutions/ countries and their collaborative associations, keyword cooccurrence, and bursts analysis, which can significantly contribute to revealing the current status, hotspots, and research trends over time in given research fields (17). To the best of our knowledge, although the number of annual publications continues to grow rapidly, no in-depth bibliometric analysis has been conducted in this field.…”

Section: Introductionmentioning

confidence: 99%

Global research trends between gut microbiota and lung cancer from 2011 to 2022: A bibliometric and visualization analysis

Chen

Lai²,

Ye³

et al. 2023

Front. Oncol.

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BackgroundAn increasing number of studies have found that the gut microbiota was related to the occurrence and development of lung cancer. Nonetheless, publication trends and research hotspots in this field remain unknown. The study aimed to perform a bibliometric analysis to systematically identify publication trends and research hotspots in the field of gut microbiota and lung cancer research within a 12-year panorama.MethodsPublications related to the gut microbiota and lung cancer between 1 January 2011 and 25 October 2022 were retrieved from the Web of Science Core Collection (WoSCC) database. The online analytic tool of the WoSCC was used to analyze various bibliometric parameters. The bibliometrics website, CiteSpace, and VOSviewer were used to identify research trends and hotspots.ResultsA total of 375 publications related to the gut microbiota and lung cancer were extracted from WoSCC and identified for analysis. The number of annual publications has grown rapidly since 2018 and reached a peak in 2022. China was the most prolific country in this field, with 120 publications, followed by the United States (114), with the highest H-index of 31. Additionally, France ranked the highest with an average of 133 citations, while the leading institution and journal were the Unicancer and the International Journal of Molecular Sciences, respectively. Interestingly, Routy Bertrand was the most prolific author and also the most cited author in terms of H-index and citations. Reference and keyword burst detection indicated that the research hotspots mainly included 1) the gut microbiota directly affects the efficacy of immunotherapy for lung cancer, 2) the application of different gut bacteria on lung cancer, and 3) the mechanism of the gut microbiota on lung cancer.ConclusionThe findings of this study revealed the general publication trends and evolving research hotspots in the field of gut microbiota and lung cancer at a global level. The research hotspots focused on the clinical application of the gut microbiota combined with immunotherapy in lung cancer and its mechanism. The findings of this study provide new perspectives on the field, which may shed light on a beneficial impact on further etiological studies, diagnosis, and treatment for lung cancer.

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“…Although more than 600 E3 ligases are encoded by human genome, only less than 10 E3 ligases were developed as ligands for the development of PROTAC degraders, including von Hippel‐Lindau (VHL), cereblon (CRBN), mouse double minute 2 (MDM2), cellular IAP1 (cIAP1), Kelch‐like ECH‐associated protein‐1 (KEAP1), DDB1‐cullin 4‐associated factor (DCAF), RING finger protein (RNF), aryl hydrocarbon receptor (AHR), and others (Figure 1). 66,74,98–104 Therefore, it is urgent to develop new and efficient E3 ligands to expand the role of PROTAC technology in drug discovery and development 105–112 . In this review, we systematically summarize all reported E3 ligases and their corresponding small molecule ligands for the successful development of PROTAC degraders.…”

Section: Introductionmentioning

confidence: 99%

PROTACs: A novel strategy for cancer drug discovery and development

Han

Sun

2023

MedComm

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Proteolysis targeting chimera (PROTAC) technology has become a powerful strategy in drug discovery, especially for undruggable targets/proteins. A typical PROTAC degrader consists of three components: a small molecule that binds to a target protein, an E3 ligase ligand (consisting of an E3 ligase and its small molecule recruiter), and a chemical linker that hooks first two components together. In the past 20 years, we have witnessed advancement of multiple PRO-TAC degraders into the clinical trials for anticancer therapies. However, one of the major challenges of PROTAC technology is that only very limited number of E3 ligase recruiters are currently available as E3 ligand for targeted protein degradation (TPD), although human genome encodes more than 600 E3 ligases. Thus, there is an urgent need to identify additional effective E3 ligase recruiters for TPD applications. In this review, we summarized the existing RING-type E3 ubiquitin ligase and their small molecule recruiters that act as effective E3 ligands of PRO-TAC degraders and their application in anticancer drug discovery. We believe that this review could serve as a reference in future development of efficient E3 ligands of PROTAC technology for cancer drug discovery and development.

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A bibliometric analysis of PROTAC from 2001 to 2021

Cited by 53 publications

References 141 publications

Knowledge-Map Analysis of Undergraduate Biochemistry Teaching Research: A Bibliometric Study from 2012 to 2021

Knowledge-Map Analysis of Undergraduate Biochemistry Teaching Research: A Bibliometric Study from 2012 to 2021

Global research trends between gut microbiota and lung cancer from 2011 to 2022: A bibliometric and visualization analysis

PROTACs: A novel strategy for cancer drug discovery and development

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