A Bibliometric Review of Publications on Oxidative Stress and Chemobrain: 1990–2019

Abstract

Oxidative stress is considered one of the possible mechanisms behind chemobrain or the cognitive dysfunction persistent after chemotherapy treatment. Breast cancer patients have reported chemobrain symptoms since the 1990s. In this present bibliometric review, we employed the VOSviewer tool to describe the existing landscape on literature concerning oxidative stress, breast cancer chemotherapies, and chemobrain. As of 2019, 8799 papers were listed in the Web of Science database, with more than 900 papers published each year. As expected, terms relating to oxidative stress, mitochondria, breast cancer, and antioxidants have occurred very often in the literature throughout the years. In recent years, there has been an increase in the occurrence of terms related to nanomedicine. Only within the last decade do the keywords ‘brain’, ‘blood-brain barrier’, and ‘central nervous system’ appear, reflecting an increased interest in chemobrain. China has become the most prolific producer of oxidative stress and chemotherapy related papers in the last decade followed by the USA and India. In conclusion, the subject of oxidative stress as a mechanism behind chemotherapies’ toxicities is an active area of research.

Effects of D‐CAG chemotherapy regimen on cognitive function in patients with acute myeloid leukaemia: A resting‐state functional magnetic resonance imaging study

“…The chemotherapy drugs can induce decreased neurogenesis and increased neuronal degeneration and neuronal apoptosis, which further cause the damage of normal neurons in the brain and aggravate the cognitive impairment of cancer survivors (Dias‐Carvalho et al, 2022; Rao et al, 2022; Sekeres et al, 2021). The underlying biological mechanism might be related to the increased oxidative stress activity/oxidative stress injury caused by accumulation of reactive oxygen species and neuroinflammation reactions (Cardoso et al, 2020; Lacourt & Heijnen, 2017; McElroy & Allen, 2020). In recent years, more and more attention has been paid to PCCI, and a large number of neuroimaging studies had explored the neural mechanism underlying ‘chemobrain’, leading to cognitive impairment in cancer patients receiving chemotherapy (Bernstein et al, 2021; Simó et al, 2013).…”

Exploring Research Trend and Hotspots on Oxidative Stress in Ischemic Stroke (2001–2022): Insights from Bibliometric

“…Data collection WOS core collection database is one of the most comprehensive, systematic and authoritative databases, containing over 13000 internationally recognized in uential academic journals that have been widely used for bibliometric analysis [19,20]. We referred to previous publications and developed search strategies related to oxidative stress and ischemic stroke (Table S2) [21,22]. Inclusion and exclusion criteria are shown in Fig.…”

Research trends and prospects on brain metastasis from breast cancer: A bibliometric analysis

“…Bibliometric analysis employs citation count as an assessment to measure of research quality ( 8 ). As a quantitative method, bibliometric analysis helps to trace the research profiles of different countries, institutions, and researchers that promoted the scientific production, behavior, and development in the related fields ( 9 , 10 ). Bibliometric reviews on breast cancer have covered several topics, focusing on a variety of different treatments including nanomedicine ( 9 ), immunotherapy ( 11 ), the application of pan-cancer studies in treatment ( 12 ), and radiotherapy ( 13 ).…”