A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis

Venken, Koen; Seeuws, Sylvie; Zabeau, Lennart; Jacques, Peggy; Decruy, Tine; Coudenys, Julie; Verheugen, Eveline; Windels, Fien; Catteeuw, Dominiek; Drennan, Michael; Calenbergh, Serge Van; Lambrecht, Bart N.; Yoshimura, Akihiko; Tavernier, Jan; Elewaut, Dirk

doi:10.1016/j.jhep.2013.08.008

Cited by 20 publications

(15 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Important scientific verification is provided by Mejia et al linking both leptin and mTORC1 in manipulating immune responses in T cells. Correspondingly, metabolic regulation of T cells and iNKT cells by leptin is demonstrated by Venken et al …”

Section: Immunometabolism In Metabolic Deregulationmentioning

confidence: 87%

Immunometabolism features of metabolic deregulation and cancer

Wang

Ping

Bakht

et al. 2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

Immunometabolism is a branch dealing at the interface of immune functionalities and metabolic regulations. Considered as a bidirectional trafficking, metabolic contents and their precursors bring a considerable change in immune cells signal transductions which as a result affect the metabolic organs and states as an implication. Lipid metabolic ingredients form a major chunk of daily diet and have a proven contribution in immune cells induction, which then undergo metabolic pathway shuffling inside their ownself. Lipid metabolic states activate relevant metabolic pathways inside immune cells that in turn prime appropriate responses to outside environment in various states including lipid metabolic disorders itself and cancers as an extension. Although data on Immunometabolism are still growing, but scientific community need to adjust and readjust according to recent data on given subject. This review attempts to provide current important data on Immunometabolism and consequently its metabolic ramifications. Incumbent data on various lipid metabolic deregulations like obesity, metabolic syndrome, obese asthma and atherosclerosis are analysed. Further, metabolic repercussions on cancers and its immune modalities are also analysed.

show abstract

Section: Immunometabolism In Metabolic Deregulationmentioning

confidence: 87%

Immunometabolism features of metabolic deregulation and cancer

Wang

Ping

Bakht

et al. 2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…The two cytokines that play this role in professional APC, IL‐12 and IL‐18, do not seem to be secreted by adipocytes in significant amounts, suggesting that other factors like adipokines may fulfil this role. Interesting candidates for this are for example leptin and adiponectin, as iNKT cells express the receptors for both adipokines . As leptin levels increase and adiponectin levels decrease in obesity, these adipokines may present an apoptotic/toxic and a pro‐survival signal for iNKT cells, respectively, thereby contributing to the decrease in AT‐resident iNKT cell numbers in obesity.…”

Section: Adipocyte–inkt Cell Interplay: Future Directionsmentioning

confidence: 99%

“…Interesting candidates for this are for example leptin and adiponectin, as iNKT cells express the receptors for both adipokines. 87,88 As leptin levels increase and adiponectin levels decrease in obesity, these adipokines may present an apoptotic/toxic and a pro-survival signal for iNKT cells, respectively, thereby contributing to the decrease in AT-resident iNKT cell numbers in obesity. The finding that Ob/Ob micewhich lack the leptin genedisplay reduced iNKT cell numbers 35 supports this view.…”

Section: Cd1d Loading and Presentationmentioning

confidence: 99%

Endogenous lipid antigens for invariant natural killer T cells hold the reins in adipose tissue homeostasis

et al. 2017

View full text Add to dashboard Cite

The global obesity epidemic and its associated co-morbidities, including type 2 diabetes, cardiovascular disease and certain types of cancers, have drawn attention to the pivotal role of adipocytes in health and disease. Besides their 'classical' function in energy storage and release, adipocytes interact with adipose-tissue-resident immune cells, among which are lipid-responsive invariant natural killer T (iNKT) cells. The iNKT cells are activated by lipid antigens presented by antigen-presenting cells as CD1d/lipid complexes. Upon activation, iNKT cells can rapidly secrete soluble mediators that either promote or oppose inflammation. In lean adipose tissue, iNKT cells elicit a predominantly anti-inflammatory immune response, whereas obesity is associated with declining iNKT cell numbers. Recent work showed that adipocytes act as non-professional antigen-presenting cells for lipid antigens. Here, we discuss endogenous lipid antigen processing and presentation by adipocytes, and speculate on how these lipid antigens, together with 'environmental factors' such as tissue/organ environment and co-stimulatory signals, are able to influence the fate of adipose-tissue-resident iNKT cells, and thereby the role of these cells in obesity and its associated pathologies.

show abstract

“…They showed that one of these, LEP- (116)(117)(118)(119)(120)(121)(122)(123)(124)(125)(126)(127)(128)(129)(130), was effective in reducing food intake, body weight and glucose levels in leptin deficient animals [52]. Follow-up in vitro experiments and studies in db/db mice showed that these effects do not require interaction with the LR long form.…”

Section: Leptin Peptide Modulatorsmentioning

confidence: 99%

“…We could show that administration of nanobodies directed against the LR CRH2, IGD or FN III domains increased body weight, body fat content, food intake, liver size and serum insulin levels [136]. A CRH2-specific nanobody exacerbated concanavalin A (Con A) induced hepatitis in wild type mice but not in invariant natural killer T (iNKT) cell deficient animals [124]. Finally, local administration of the same nanobody at low dose adjacent to a tumor decreased tumor mass with no visible effects on body weight or food intake in a mouse model of melanoma [79].…”

Section: Leptin and Lr Antibodies And Nanobodiesmentioning

confidence: 99%