A biochemical and morphological study of the cotton pellet granuloma in the rat: effects of dexamethasone and indomethacin (Abstract)

Bailey, Philip J.; Sturm, Anita; Lopez-Ramos, B.

doi:10.1007/978-94-010-9423-8_50

Cited by 11 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A few days after pellet implantation, the amount of newly formed tissue can be measured, after its removal, by weighing the dried pellets. The increased weight of the dried cotton pellet has been shown to correlate with the amount of granulomatous tissue formed (Bailey et al, 1982). As may be seen from inspection of Table 2, ethanol extract of C. crassifolius, at doses of 90 and 180 mg/kg, effectively inhibited cotton pellet granuloma formation.…”

Section: Discussionmentioning

confidence: 93%

“…When the acute response is insufficient to eliminate the pro-inflammatory agents, it leads to a chronic inflammatory reaction. Chronic inflammation includes a proliferation of fibroblasts and the infiltration of neutrophils and mononuclear cells (Swingle and Shideman, 1972;Bailey et al, 1982). A few days after pellet implantation, the amount of newly formed tissue can be measured, after its removal, by weighing the dried pellets.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-nociceptive and anti-inflammatory effects of Croton crassifolius ethanol extract

Zhao

Fang

et al. 2012

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Anti-nociceptive and anti-inflammatory effects of Croton crassifolius ethanol extract

Zhao

Fang

et al. 2012

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…Granulomatous infl ammation is a morphological type of chronic state of infl ammation, and the cotton pellet-induced granuloma in rats is a representative model for studying drugs against this infl ammation phase (Bailey et al, 1982). Anti-infl ammatory action of PPE Pm was assayed in this model and compared with that of bromelain and dexamethasone.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Anti-Inflammatory Activity of Pseudananas macrodontes (Morr.) Harms (Bromeliaceae) Fruit Extract in Rats

Errasti

Caffini

Pelzer

et al. 2013

Zeitschrift Für Naturforschung C

View full text Add to dashboard Cite

Several species of the family Bromeliaceae are characterized by the production of proteases in unusual amounts, especially in fruits. Bromelain, an extract rich in cysteine endopeptidases obtained from Ananas comosus L., and a few other proteases have been used as anti-infl ammatory agents for some years, but bromelain is still mainly being used as alternative and/or complementary therapy to the treatment with glucocorticoids, nonsteroidal antirheumatics, and immunomodulators. In this study, the anti-infl ammatory action of a partially purifi ed extract from Pseudananas macrodontes (Morr.) Harms fruits (PPE Pm ) is presented, whose main components are cysteine endopeptidases. The effect of PPE Pm was assessed in carrageenan-induced and serotonin-induced rat paw edema, as well as in the cotton pellet granuloma model. Doses with equal proteolytic activity of PPE Pm and bromelain produced signifi cantly similar anti-infl ammatory responses in the acute infl ammatory models assayed, supporting the hypothesis that proteolytic activity could be responsible for the anti-infl ammatory action. On the contrary, comparable anti-infl ammatory effects of PPE Pm and bromelain in the chronic infl ammatory assay required a much lower proteolytic activity content of PPE Pm , which could be due to a differential affi nity for the protein target involved in this process.

show abstract

“…According to Parvataneni et al (2005), cotton pellet granuloma is the most suitable method for studying the efficacy of drugs against proliferative phase of inflammation. The granuloma formed by day 7 is characterized by the formation of a vascularized fibrous capsule containing fibroblasts and infiltrating mononuclear cells (Bailey et al 1982). In this model, the aqueous and organic extracts of leaves and bark of A. visco effectively inhibited the development of granulomatous tissues as compared to control group, showing the leaf extract has the highest inhibition.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory effect of Acacia visco extracts in animal models

et al. 2010

View full text Add to dashboard Cite

The aqueous and organic extracts of Acacia visco Lor. Ap Griseb (Fabaceae) were tested for antiinflammatory activity in experimental models in rat. Besides, the free-radical scavenging capacity of extracts from A. visco was determined. The extracts revealed antiinflammatory effect against carrageenan-induced oedema, phospholipase A 2 -induced oedema, cotton pellet-induced granuloma and they did not show acute toxic effect. Among the class of compounds characterized from A. visco leaves, the triterpenoid 20(29)-lupen-3b-ol (lupeol), 12-ursen-3b-ol (a-amyrin) and 12-oleanen-3b-ol (b-amyrin) may be mainly responsible for the pharmacological activities.

show abstract

A biochemical and morphological study of the cotton pellet granuloma in the rat: effects of dexamethasone and indomethacin (Abstract)

Cited by 11 publications

References 0 publications

Anti-nociceptive and anti-inflammatory effects of Croton crassifolius ethanol extract

Anti-nociceptive and anti-inflammatory effects of Croton crassifolius ethanol extract

Evaluation of Anti-Inflammatory Activity of Pseudananas macrodontes (Morr.) Harms (Bromeliaceae) Fruit Extract in Rats

Anti-inflammatory effect of Acacia visco extracts in animal models

Contact Info

Product

Resources

About